氧化障碍

One hand mechanical obstruct led to the increase of veinous resistance and the obstacle of microcirculation, the other hand the adhesive PMN was activated in excess, the white blood cells released a lot of enzymes, in which PMN-elastase can decompose the components of cell and many albumens, inclusive of immunoglobulin、alexin and fibrication. These components induced the injury of the pancreatic capillary vessels and cell and lysosome enzy made the tissue protein hydrolyze and produced unsaturated fatty acids, which destroyed the structure and function of cellar membrane. The inflammatory cellar factors activate other immunocytes to produce the injury and necrosis of tissue, which aggravated the pathological injury and led to shock、pyaemia and MODS. So ICAM-1 and LFA-1 played an important role in SAP. Frossard found that the expression of ICAM-1 in the rat model, especially in serum、pancreas and lung. All these showed ICAM-1 is an important factor in AP and concomitant lung injury.

胰腺小叶组织局部血管EC首先被激活，ICAM-1表达升高，与被激活的PMN表面表达的LFA-1相结合，"PMN-EC"相互作用加剧，一方面机械性阻塞毛细血管导致静脉阻力增加、微循环障碍；另一方面粘附的PMN过度吞噬或激活，当白细胞吞噬的颗粒不能被封闭隔离，连同细胞内的酶被释放出来，其中的PMN-elastase能够降解细胞基质中各种成分，水解多种蛋白，加重胰腺的毛细血管内皮细胞和腺泡的损伤；释放的溶酶体酶使组织蛋白水解，产生的不饱和脂肪酸引发脂质过氧化方应，破坏细胞膜的结构和功能；释放的炎性细胞因子，激发其他的免疫细胞的功能，导致进一步的组织损伤和坏死，加重SAP的病理损伤，最终导致休克、脓毒血症及多器官功能障碍等严重后果。

Objective To explore the effect of total parenteral nutrition supplemented with glutamine on the activity of plasma diamine oxidase and D-lactate content in blood of patients with multiple organ dysfunction syndrome.

目的 探讨添加谷氨酰胺的全胃肠外营养对多器官功能障碍综合征患者血浆二胺氧化酶、D-乳酸的影响。

When the relationship of the nitrogen oxide produced by the angina pectoris treatment glyceryl trinitrate and blood vessel expansion is discovered, it developed the medicine used to treat male sex impotency. and, it is expected to develop medicines to treat scurvy and cancer.

用於狭心症治疗的硝化甘油所产生的一氧化氮no与血管扩张的关系被发现后，开发了男性性功能障碍的治疗药，此外在坏血症以及癌症方面的治疗药效也令人期待。

When the relationship of the nitrogen oxide produced by the angina pectoris treatment Glyceryl Trinitrate and bloodvessel expansion is discovered, it developed the medicine used to treat male sex impotency. And, it is expected to develop medicines to treat scurvy and cancer.

用於狭心症治疗的硝化甘油所产生的一氧化氮NO与血管扩张的关系被发现后，开发了男性性功能障碍的治疗药，此外在坏血症以及癌症方面的治疗药效也令人期待。

These data suggest that in response to smoke exposure, TNF-alpha-mediated down-regulation of PGC-1alpha may be a key step leading to vascular and myocyte dysfunction, effects that are more evident in oxidative than glycolytic skeletal muscles.

这些数据表明，响应吸烟暴露，肿瘤坏死因子-α介导的PGC-1α下调可能是导致血管和心肌功能障碍的关键一步，这种作用在氧化型肌肉比在糖酵解骨骼肌更明显。

Examination revealed the thyroid to be about 50-150 gm and thyroid nodules were present in 3 cases. 3 of them had deaf -mutism, in another, partial deaf -mutism.

全部患者的血清甲状腺素浓度都在正常低值范围，过氯酸钾释放试验时吸~(131)I率均有明显下降，甲状腺素有机合成障碍的环节都可能是碘的氧化缺损。

BACKGROUND: The structural and functional impairment of endothelium cells were mainly presented by lowered endothelium activity, reduced nitrogen monoxide production, as well as increased endothelium vasoconstrictor peptide.

背景：内皮细胞发生结构损伤和功能障碍的主要特征为内皮细胞活性降低或释放的一氧化氮减少，内皮缩血管肽产生增加。

Nitric oxide is involved in vasodilatation, and low levels are associated with mental and physical fatigue and sexual dysfunction.

一氧化氮参与舒张、水平低，与身心疲劳、性功能障碍。

Therefore, the aim of this research is to compare the antioxidant, acetylcholinesterase-inhibiting and monoamine oxidase -inhibiting activities of these four parts of Morus alba. In addition, I also explored the mechanism of the ameliorating effects of scopoletin on the scopolamine induced memory impairment in rats.

因此，本研究针对桑四个药用部位之甲醇抽提物进行抗氧化活性及对乙醯胆碱酯酶、单胺氧化酶的抑制活性之分析比较，之后再探讨其香豆素类成分 scopoletin对 scopolamine 诱发大鼠记忆障碍之影响，及其改善作用机制。

One hand mechanical obstruct led to the increase of veinous resistance and the obstacle of microcirculation, the other hand the adhesive PMN was activated in excess, the white blood cells released a lot of enzymes, in which PMN-elastase can decompose the components of cell and many albumens, inclusive of immunoglobulin、alexin and fibrication. These components induced the injury of the pancreatic capillary vessels and cell and lysosome enzy made the tissue protein hydrolyze and produced unsaturated fatty acids, which destroyed the structure and function of cellar membrane. The inflammatory cellar factors activate other immunocytes to produce the injury and necrosis of tissue, which aggravated the pathological injury and led to shock、pyaemia and MODS. So ICAM-1 and LFA-1 played an important role in SAP. Frossard found that the expression of ICAM-1 in the rat model, especially in serum、pancreas and lung. All these showed ICAM-1 is an important factor in AP and concomitant lung injury.

胰腺小叶组织局部血管EC首先被激活，ICAM-1表达升高，与被激活的PMN表面表达的LFA-1相结合，&PMN-EC&相互作用加剧，一方面机械性阻塞毛细血管导致静脉阻力增加、微循环障碍；另一方面粘附的PMN过度吞噬或激活，当白细胞吞噬的颗粒不能被封闭隔离，连同细胞内的酶被释放出来，其中的PMN-elastase能够降解细胞基质中各种成分，水解多种蛋白，加重胰腺的毛细血管内皮细胞和腺泡的损伤；释放的溶酶体酶使组织蛋白水解，产生的不饱和脂肪酸引发脂质过氧化方应，破坏细胞膜的结构和功能；释放的炎性细胞因子，激发其他的免疫细胞的功能，导致进一步的组织损伤和坏死，加重SAP的病理损伤，最终导致休克、脓毒血症及多器官功能障碍等严重后果。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。