氧丙环

The annulation of stilbene compounds were studied. Phenanthrene derivates-interme diates of tylophorine were synthesized by annulation from-2,3-bis(3,4-dimethoxyphen yl)acrylic acid and-2,3-bis(3,4-dimethoxyphenyl) acrylonitrile with phenyliodine diace tate as a friendly and high efficient catalyzer.The route was first reported, whose application foreground would be promising.The catalyzer will be used to study of synthesi- zing a series of new phenanthrenes.

本文还探索了简单类化合物关环反应，并研究出用廉价高效对环境友好的催化剂-二乙酸碘苯成功地将类化合物－3，4-二甲氧基-α-(3，4-二甲氧苯基)-肉桂酸和-2-(3，4-二甲氧苯基)-3-(3，4-二甲氧苯基)-丙烯关环形成相应的菲环衍生物－娃儿藤碱重要中间体，此方法在国内尚属首次，具有重要的应用价值，此外可用此催化剂研究一系列类化合物的关环反应。

Ophenyl phenol,ophenyl phenol sodium salt tetrahydrate,7ADCA,2ethyl phenyl hydrazine hydrochloride,2,3dihydrofuran,7ethyl3(2hydroxy ethyl)indole,methyl ester of etodolac; 1,8diethyl1,3,4,9tetrahydropyrano[3.4b] indole1acetic acid methyl ester,5chloro2methoxy benzoic acid,4(2aminoethyl)benzene sulfonamide,5cyano phthalide,phthalhydrazide,9thioxanthenone,n[(1,4benzodioxane2yl)carboxyl]piperazine HCL,2chloro4amino6,7dimethoxyquinazoline,2chloro benzimidazole,1(4fluorobenzyl)2chlorobenzimidazole,2methylthio4pyrimidone,5amino4imidazole carboxamide HCL,6chloro2hexanone,11oxo6.11hydrodibenzothiepin,6,11dihydrodibenzooxepin11one,10,11dihydrodibenzocyclohepten5one;dibenzosuberone,dibenzo cyclohepten5one;dibenzosuberenone,3,5dihydroxy benzoic acid,3,5dihydroxy benzyl alcohol,2mercapto benzimidazole,3,4dihydroxy benzaldehyde,3,4dihydroxy benzonitrile,2amino5chloro benzonitrile,2(4chlorophenoxy)ethyl chloride,2(4chloro phenoxy)tert,butane,ditrimethylol propane;DTMP,2,2bis(4hydroxyphenyl)butane; bisphenol B,1,1'bis(4hydroxyphenyl)cyclohexane;bisphenol Z,tetrabromobisphenolS,3,5ditertbutyl salicylic acid,3,4,5trihydroxy benzoic acid stearyl ester,1,2,4trimethoxybenzene.

华业公司产品：邻苯基苯酚，邻苯基苯酚钠盐，7氨基3去乙酰氧基头孢烷酸，邻乙基苯肼盐酸盐，2，3二氢呋喃，7乙基色氨醇，依托度酸甲酯，5氯2甲氧基苯甲酸，4(2氨乙基)苯磺酰胺，5氰基苯酞，双酮酞嗪，9噻吨酮，N〔(1，4苯并二恶烷2基)羰基〕哌嗪盐酸盐，2氯4氨基6，7一二甲氧基喹唑啉，2氯苯并咪唑，1(4氟苄基)2氯苯并咪唑，2甲硫基4嘧啶酮，5氨基咪唑4 甲酰胺盐酸盐，6氯2已酮，11氧6.11二氢苯并〔b.c〕虑平，11氧代6，11二氢二苯并氧杂卓，10，11二氢二苯并环庚烯5酮，二苯并环庚烯5酮，3，5二羟基苯甲酸，3，5二羟基苯甲醇，2巯基苯并咪唑，3，4二羟基苯甲醛，3，4二羟基苯腈，2氨基5氯苯腈，2(4氯苯氧基)1氯乙烷，2(4氯苯氧基)叔丁烷，双丙烷，2，2二(4羟基苯基)丁烷；双酚B，1，1'双(4羟基苯基)环己烷；双酚Z，2[3，5二溴4(2，3二溴丙氧基)]苯砜，3，5二叔丁基水杨酸，3，4，5三羟基苯甲酸十八烷基脂，1，2，4三甲基氧基苯。

Goal compound synthesis namely: Take the vanillic acid as outset raw material, obtains 4- hydroxyl - 3- anisole methyl formate with the methyl alcohol reflux conditions, then after the etherification, the nitration, the return to original state, the ring closure response obtains 6- methoxy - 7- animal pen oxygen radical kui zuo lin - 4- alkone, then passes through the chlorination, the substitution aniline, to escape responses again and so on animal pen oxygen radical, etherification to obtain the goal compound; The goal compound and the diethylamine had the amine substitution reaction to obtain TM1, namely 4- benzene amino - 6- methoxy - 7- [2- hydroxyl - 3-(N, N- two ethyl aminos) third oxygen radical] kui zuo lin; Through zuo has the etherification with the Austria niter to respond obtains TM2, namely 4- benzene amino - 6- methoxy - 7- [2- hydroxyl - 3-(2- methyl - 5- nitryl imidazole) third oxygen radical] kui zuo lin.

目标化合物的合成即：以香草酸为起始原料，与甲醇回流条件下得到4-羟基-3-甲氧基苯甲酸甲酯，然后经过醚化、硝化、还原、环合反应得到6-甲氧基-7-苄氧基喹唑啉-4-酮，然后再经氯化、取代苯胺、脱苄氧基、醚化等反应得到目标化合物；目标化合物与二乙胺发生胺取代反应得到了TM1，即4-苯氨基-6-甲氧基-7-[2-羟基-3-丙氧基]喹唑啉；通过与奥硝唑发生醚化反应得到TM2，即4-苯氨基-6-甲氧基-7-[2-羟基-3-(2-甲基-5-硝基咪唑)丙氧基]喹唑啉。

Synthesis of target compounds namely: to vanillic acid as the starting material with methanol under reflux conditions for 4 - hydroxy -3 - p-methyl, then ether, and nitration, reduction, cyclization reaction 6 - methoxy -7 - benzyloxy-quinazoline -4 - one, and then by the chloride in place of aniline, benzyloxy-off, such as etherification reaction of the target compounds; target compounds with the second and third occurrence of substitution reactions of amines by the TM1, that is, 4 - amino-benzene -6 - methoxy -7 - [2 - hydroxy -3 -(N, N-diethyl amino) oxy c] quinazoline; with ether occurred Ornidazole reaction of TM2, namely, 4 - amino-benzene -6 - methoxy -7 - [2 - hydroxy -3 -(2 - methyl -5 - nitroimidazole) C oxy] quinazoline.

本论文以嘌呤类似物喹唑啉为母核，分别在其4位和7位引入结构多样的取代苯氨基和柔性侧链，设计了一系列4-取代苯胺基-6-甲氧基-7-(2-羟基取代丙氧基)喹唑啉类化合物。目标化合物的合成即：以香草酸为起始原料，与甲醇回流条件下得到4-羟基-3-甲氧基苯甲酸甲酯，然后经过醚化、硝化、还原、环合反应得到6-甲氧基-7-苄氧基喹唑啉-4-酮，然后再经氯化、取代苯胺、脱苄氧基、醚化等反应得到目标化合物；目标化合物与二乙胺发生胺取代反应得到了TM1，即4-苯氨基-6-甲氧基-7-[2-羟基-3-丙氧基]喹唑啉；通过与奥硝唑发生醚化反应得到TM2，即4-苯氨基-6-甲氧基-7-[2-羟基-3-(2-甲基-5-硝基咪唑)丙氧基]喹唑啉。

New ruthenium benzylidene complexes benzylidene[1,3-bis(2,6-dimethylphenyl)-4,5-dihydroimidazol-2-ylidene] [k~2-diphenylphosphinoacetato] monochlororuthenium (46), benzylidene[1,3-bis(2,6-dimethylphenyl)-4,5-dihydroimidazol-2-ylidene][k~2-3-propionato]monochlororuthenium (47), benzylidene[1,3-bis(2,6-dimethylphenyl)-4,5-dihydroimidazol-2-ylidene] [k~2-2-benzonato]monochlororuthenium (48) featured five-membered, flexible six-membered and rigidsix-membered chelating rings respectively are prepared by reactions of complex 41 withcorresponding sodium phosphino-carboxylates. It is confirmed by X-ray crystallographicanalysis that the coordination geometries of complexes 46 and 47 are distorted squarepyramids with phosphino-carboxylate ligands chelating to ruthenium, and the coordinationbetween ruthenium and benzylidene ligands are strengthened.

用二苯基瞵乙酸盐、二苯基膦丙酸盐、二苯基膦苯甲酸盐与钌卡宾配合物41反应合成了三个新的钌卡宾配合物：含五元膦-氧螯合环的1，3-二-(2，6-二甲苯基)-4，5-二氢咪唑基1-苯亚甲基--一氯合钌(46)、含六元柔性膦-氧螯合环的[1，3-二-(2，6-二甲苯基)-4，5-二氢咪唑基1-苯亚甲基--一氯合钌(47)及含六元刚性膦-氧螯合环的[1，3-二-(2，6-二甲苯基)-4，5-二氢咪唑基]-苯亚甲基--一氯合钌(48)。X射线单晶衍射分析证明，配合物46、47都为变形的四方锥构型，膦-氧与钌形成螯合配位，其中苯亚甲基与钌的配位得以加强。

Water,caprylic/capric triglyceride,mineral oil,butylene glycol,stearic acid,acetylated lanolin,glycerin,ethylhexyl methoxycinnamate,dimethicone,polyisoprene,triethanolamine,cyclopentasiloxane,butyl methoxydibenzoylmethane,titanium dioxide,persea gratissima oil unsaponifiables,sodium DNA,borago officinalis seed oil,oenothera biennis oil,simmondsia chinensisseed oil,hydrolyzed RNA,tocopheryl acetate,urea,hydrolyzed extensin,retinyl palmitate,sodium hyaluronate,helianthus annuusseed oil,tocopherol,ascorbyl palmitate,ascorbic acid,lanolin alcohol,c12-20 acid peg-8 ester,cyclotetrasiloxane,glyceryl stearate,dimethiconol,ceteareth-20,carbomer,magnesium aluminum silicate,propylene glycol,peg-8,silica,BHT,citric acid,phenoxyethanol,methylparaben,butylparaben,ethylparaben,isobutylparaben,propylparaben,chlorhexidine digluconate

水，辛酸/癸酸三酸甘油酯，矿物油，丁二醇，硬脂酸，乙醯化羊毛脂，甘油，4-甲氧基肉桂酸-2-乙基己基酯，地美司康，聚异戊烯，三乙醇胺，环戊硅氧烷，丁基甲氧基二苯甲醯基甲烷，二氧化钛，酪梨油，DNA 钠盐，琉璃苣種子植物油，月见草油，荷荷巴籽油，水解RNA，醋酸盐维他命E，尿素，水解伸展蛋白，维他命A酯，透明质酸钠，葵花籽油，维生素E，抗坏血酸棕榈酸酯，维生素C衍生物，羊毛脂醇，C12-20 酸 PEG-8酯，环四硅氧烷，甘油硬脂酸，聚二甲基硅氧烷醇，鲸蜡硬脂醇醚-20，卡波姆，硅酸镁铝，丙二醇，聚乙二醇-8，二氧化硅，二丁基羟基甲苯，柠檬酸，苯氧乙醇，羟苯甲酯，羟苯丁酯，羟苯乙酯，羟苯甲酸异丁酯，羟苯丙酯，洗必泰葡萄糖酸盐

Profile to 2-methyl-4-propyl-1, 3-oxathiane (Fema: 3578),which is considered to be a key organoleptic constituent of Yellow Passion Fruit.

甲基-4-丙基1，3-氧硫环己烷(Fema：3578)的香气，哪一个被认为是黄热带水果的主

Two new active esters of acrylic acids monomers, N-p-acryloxybenzoyloxy succini-mide and N-p-methacryloxybenzoyloxy succinimide have been synthesized and polymerized.ABOSu and MBOSu were prepared by coupling of p-acryloxybenzoic acid or p-methacryloxybenzoie acid with N-hydroxy succinimide in the presence of dicyclohexylcarbodimide.

新的丙烯酸活性酯，N-(对甲基丙烯酰氧苯甲酰氧基)丁二酰亚胺及N-丁二酰亚胺单体分别由对甲基丙烯酰氧基苯甲酸、对丙烯酰氧基苯甲酸与N-羟基丁二酰亚胺在环已基羰二亚胺存在下经偶联反应合成。

Epoxypropyl triethyl ammonium chloride intermediate was synthesized by the reaction of triethylamine with epichlorohydrin in aqueous methanol using K_2SO_4 as catalyst.

首次将硫酸钾作为催化剂，引入到环氧丙基三乙基氯化铵中间体的合成反应中。

The optimum conditions of preparing quaternary ammonium salt of chitosan were determined as follows: the molar ratio of chitosan to glycidyl trimethyl ammonium chloride 1:3, reaction temperature 80℃and reaction time 10 h.

制备壳聚糖季铵盐的最佳反应条件为：壳(来源：A4040BC论文网www.abclunwen.com)聚糖与环氧丙基三甲基氯化铵的摩尔比为1：3、反应温度是80℃、反应时间为10小时。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。