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氢化可的松

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MethodsThe immunosuppressive mouse model was established by using hydrocortisone. Huangqi Fuzhengtang and Yupingfeng San apozema were given to the mice intragastrically. The contents of hemolysin, IL-2, and INF-γ in the mouse serum and the expression of CD3+, CD4+, and CD8+ in the peripheral blood lymphocytes were measured.

氢化可的松造成免疫低下小鼠模型,用黄芪扶正汤和玉屏风散水煮液进行灌胃,检测小鼠血清溶血素的生成、IL-2和INF-γ的含量以及外周血淋巴细胞CD3+,CD4+和CD8+的表达。

Results: The changes following hydrocortisone intervention of rats could be identified by PCA, and the kidney deficiency syndrome rats entered a state of "hyperfunction", involving a series of changes in metabolic pathway and metabolic network. The response integral area of lactic acid (δ 1.37) increased, indicating the accumulation of metabolites of lactic acid. The amount of dimethylamine (δ 2.72) also increased, indicating that the disorder of kidney function was related to kidney-deficiency syndrome. The response of creatinine (δ 3.87), asparaginic acid (δ 2.83), taurine (δ 3.44, 3.28), and hippurate (δ 7.84, 7.56, 7.64, 3.97) all decreased significantly, indicating that the hydrocortisone might cause adrenal cortex excretion injury. The response integral area of succinate (δ 2.41) and citric acid (δ 2.53, 2.68) decreased, which was usually caused by disorder of the mitochondrial function.

结果:PCA方法处理肾虚证和空白对照大鼠尿液数据显示,两组大鼠的数据可以在得分图实现分类,与对照组比较肾虚组大鼠由于氢化可的松诱导,大鼠机体进入一个过消耗后衰弱的状态,相关代谢发生显著变化,乳酸(δ 1.37)代谢发生堆积;二甲胺(δ 2.72)的含量增加,提示肾虚与肾功能异常是密切相关的;天冬氨酸(δ 2.83),牛磺酸(δ 3.44, 3.25),马尿酸(δ 7.84, 7.56, 7.64, 3.97),肌氨酸(δ 3.87)等的相对积分面积明显下降,这预示糖皮质激素可能引起了肾上腺皮质分泌功能的损害;琥珀酸(δ 2.41)和柠檬酸(δ 2.53, 2.68)是三羧酸循环能量代谢及糖酵解的中间产物,其含量的降低,通常是由于线粒体功能紊乱所引起。

Calamine lotion or hydrocortisone creams can have a similar effect.

炉甘石洗剂或氢化可的松霜可以产生类似的效果。

114 cases ulcerative colonitis from jan. 2005 to dec. 2008 in our hospital were divided into two groups. 63 cases in treatment group were given herbal decotion, 51 cases in control group were given sulfasalazine orally with succinic acid hydrogenation cortisone edema.

选择2005年1月至2008年12月来我院就诊的溃疡性结肠炎患者114例,随机分为两组,治疗组63例服用自拟中药汤剂治疗;对照组51例采用柳氮磺胺吡啶口服,琥珀酸氢化可的松灌肠。

Methods: The methods of the increase of blood capillary permeability of the abdominal in mice induced by injection of acetic acid and the swelling of the ear in mice caused by crotin were used for antiinflammatory experiments, aspirin and hydrocortison were respectively used as the positive control;...

小鼠随机分组,抗炎实验用醋酸诱发小鼠腹腔毛细血管通透性增高和用巴豆油诱发小鼠耳肿胀,阳性对照分别为阿斯匹林组和氢化可的松组;镇痛实验采用醋酸诱发小鼠腹痛和用热板诱发小鼠足痛,阳性对照为盐酸吗啡组。

EGF remarkably stimulated the dermal sheath fibroblasts, dermal Tibroblasts and demal papilla cells. Effection on the dermal sheath fibroblasts was the strongest. bFGF, GM-CSF, insulin and hydrocortisone had not effective on them.

EGF对真皮鞘细胞、真皮成纤维细胞和毛乳头细胞有显著的促生长作用,其中对真皮鞘细胞的作用最强,而bFGF、GM-CSF、胰岛素+氢化可的松对三种细胞没有明显的作用。

Desonide ; Hydrocortisone butyrate ; Mometasone furoate ; Dermopathic treatment

地奈德;丁酸氢化可的松;糠酸莫米松;皮肤病治疗

Immunofluorescence staining and western blotting indicated that hyphal fragments also enhanced the expression of TLR2 and TLR4 in protein level.

荧光免疫组织化学和western blot结果显示灭活菌丝片断能促进TLR2和TLR4蛋白水平的表达,而且这种表达能进一步被氢化可的松上调。

On groovy cure foundation, remedial group (N=21) application is methylic prednisone dragon 1 Mg/, vein a bit, q12 H, use consecutively 5 D; contrasts group (N=21) uses hydrogenation cortisone 5 Mg/, 1 / D, use consecutively 5 D.

在常规治疗基础上,治疗组(n=21)应用甲基强的松龙1 mg/,静脉点滴,q12 h,连用5 d;对照组(n=21)采用氢化可的松5 mg/,1次/d,连用5 d。

Serum ECP were measured with Pharmacia UniCAP system and the lung functions tests were examined with pneumometer.

两组患者在常规治疗基础上给予糖皮质激素:泼尼松30mg/d或相当剂量的氢化可的松。3组研究对象均采用荧光酶标法pharmaciaCAP检测系统测定治疗前、后血清ECP及1s用力呼气容积(FEV1)。

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