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:To study the relation between Fluconazole -resistance mechanism of Candida albicans with mutation in ERG11 gene, and determine the mechanism of drug-resistance to azole in Candida albicans.

摘要探讨白假丝酵母菌靶酶编码基因(ERG11)突变与氟康唑耐药性的关系，以分析白假丝酵母菌对唑类药物耐药机制。

In the present study, we examined the large-scale gene expression profiles with six sets of matched clinical and experimental fluconazole susceptible and resistant C. albicans strains by microarray analysis. We observed that azole resistances developed in multiple circumstances are all associated with increased expression of CDR mRNA. We also identified some common differential expressed genes and some interesting function-linked gene groups involved in drug-resistance.

利用所构建的基因芯片我们研究了共六对氟康唑敏感和耐药白念珠菌配对菌株的大规模基因表达谱，证实不同环境下产生的白念珠菌耐药性均与多药耐药基因CDR的mRNA表达增加有关，并从中鉴定了一些与药物耐受性相关的共同差异表达基因和一些有趣的功能连锁基因群。

Products are widely used in rubber, plastic, bakelite, graphite, grinding wheel, resin, PTFE products, asbestos products and other industries.

产品广泛应用于橡胶、塑料、胶木、石墨、砂轮、树脂、四氟制品、石棉制品等行业。

Japan's main Samsung, Japan Bando, Germany than Austria, the United States Gates, Italy SAMPLA, Netherlands DERCO, varieties are: conveyor belt, using Teflon oven conveyor belt, V-belt, timing belts, speed zone, on-chip baseband, with a round steel and steel deduction and the deduction of such mechanical and electrical spare parts, the operating company, I really merged with the world.

主要有日本三星、日本阪东、德国奥比、美国盖茨、意大利SAMPLA、荷兰DERCO等，品种有：输送带、烘箱用铁氟龙输送带、三角带、同步带、变速带、片基带、圆带以及钢扣和钢扣机之类机电零配件，我公司的经营真正做到了与世界并轨。

Our products are mainly the business has four categories: First, the main agent of some well-known international brands of industrial belts, the Netherlands has DERCO, FABREEKA of PVC, PU, PE, SIR conveyor; Germany OPTIBELI, USA DAYCO, GATES, Japan BANDO, MITSUBOSAI the Triangle, timing belt, transmission belt, wide belt and so on; Japan Nitta textile special flat belt; BRECO Germany and Italy MEGADYNE polyurethane timing belt; CHEMFAB the United States of Teflon mesh belt and adhesive tape .

我司的经营产品主要有四大类：其一，主要是代理经销国际上的一些知名品牌的工业皮带，有荷兰DERCO，FABREEKA的PVC，PU，PE，SIR输送带；德国OPTIBELI，美国DAYCO，GATES，日本BANDO，MITSUBOSAI的三角带，同步带，变速带，广角带等；日本NITTA的纺织业专用平皮带；德国BRECO和意大利MEGADYNE的聚氨酯同步带；美国CHEMFAB的特氟龙网带和胶布。

Transmission of the main sales agents various types of industrial belt: Germany orbit, Japan Bando Samsung Song, the United States Gates, Italy, and so Mr Gaudi Brand-name industrial belt, double-sided tooth belt, T2.5, T5, T10, T20, AT5, AT10, AT20, DT5, DT10, DT20 Metric timing belt, with variables, production and sales network of stainless steel conveyor belt, high temperature iron fluoride Long network zone, with Juan Zhi network, with high temperatures blankets; PVC, PU, PE, SIR conveyor belt, anti-static tape.

传动件主要代理销售各类工业皮带：德国奥比特，日本阪东三星松田，美国盖茨，意大利麦高迪等名牌工业同步带，双面齿同步带，T2.5，T5，T10，T20，AT5，AT10，AT20，DT5，DT10，DT20公制同步带，变数带，生产销售不锈钢输送网带，耐高温铁氟龙网带，聚胺脂网带，耐高温毛毡带；PVC，PU，PE，SIR输送带，防静电胶带。

Benzene barbitone is with medicine before art sodium 0.1, east Lang Dang alkaline 0.03mg/kg, complete hemp is revulsive use Mi Zun phenol of third of stable, different, fragrance too; of bromic ammonium of library of the Buddhist nun, dimension is maintained use static suck compound, target of bromic ammonium of library of different third phenol, dimension accuses to be defeated note, complementary aether of fluorine suction other.

术前用药为苯巴比妥钠0.1、东莨菪碱0.03mg/kg，全麻诱导采用咪唑安宁、异丙酚、芬太尼、维库溴铵；维持采用静吸复合，异丙酚、维库溴铵靶控输注、辅吸异氟醚。

A small amount of barite is found in the minerals.

发现氟碳酸盐矿物中混有少量的重晶石。

Arrest face guard closely patient mouth bazoo, the operation begins after 7 fluorine aether sucks 30 S.

将面罩紧扣患者口鼻，七氟醚吸30 s后开始手术。

The results suggested that the impairment on the learning capability induced by fluorosis may be closely related with the pathological changes of synaptic structure in the brain of mice.

结果提示，慢性氟中毒对小鼠的学习能力的显著影响可能与其脑内突触界面结构的病理变化有关。

The labia have now been sutured together almost completely.The drains and the Foley catheter come out at the top.

此刻阴唇已经几乎完全的缝在一起了，排除多余淤血体液的管子和Foley导管从顶端冒出来。

To get the business done, I suggest we split the difference in price.

为了做成这笔生意，我建议我们在价格上大家各让一半。