毛细胞

Methods Take the audibility threshold、basilar membrane stretched preparation and immunofluorescence stain as the index, observing that the rats were put in the stationary noise before 30days until after that for 7days, have vitamin E and sodium chloride , check the auditory brain stem potential and the lost rate and NF-κB of the OHC in the cochlea hair cells expression quantitative analysis.

以听阈、耳蜗基底膜铺片及免疫荧光染色为指标，观察大白鼠在稳态噪声持续暴露之前30天至暴露后7天，灌维生素E或生理盐水，对大白鼠听觉脑干电位分析和耳蜗外毛细胞丢失率分析及NF-κB在耳蜗毛细胞中表达定量分析。

Protect integrity of lysosome in hairy cells of the cochlea, and prevent from autolysis of the hair cells, which may be one of the action mechanisms.

保护耳蜗毛细胞内溶酶体的完整性，防止毛细胞的自溶性损伤可能是当归的作用机制之一。

Calcium activated potassium ionic channel is abbreviated to be BK, which is situated at the bottom of hair cell cilium, and is the important ionic channel of the electronic activity of hair cell, take part in the high frequency hearing, the significant change was found in the deafness by using the patch clamp.

钙激活钾离子通道简称BK通道，存在于毛细胞纤毛的底部，是毛细胞电活动重要的离子通道，参与高频听力发生，以往膜片钳的方法证实BK通道在耳聋时电生理功能发生重要改变。

ZO1 and Cx26 expressions in the sensory epithelium have different location and were not overlapped. Tight junctions maintain the ion barrier between the endolymph and perilymph,and gap junctions take part in ion transportation.

Cx26和Cx30分布在基底膜的各种支持细胞，在感觉毛细胞没有表达；此外，该研究发现Cx26和ZO1在耳蜗内具有不同的表达方式和表达部位，紧密连接ZO1在网状板面构成了毛细胞之间或与其支持细胞之间的离子屏障，阻止内、外淋巴之间的相互流通，保持了各自之间的离子平衡；缝隙连接则表达在基底膜的深层，参与离子转运。

The mean tumor volume at the time of GKS was 2.5 cm3. In 10 cases a tumor specimen was obtained either by open surgery or stereotactic biopsy, securing the diagnosis of pilocytic astrocytoma in five patients and nonpilocytic astrocytoma in five others.

开始GKS治疗时的平均体积是2.5 cm3.10例的肿瘤标本通过开放手术或立体定向的活检获得，得出的诊断是：5例毛细胞性星形细胞瘤，5例为非毛细胞性星形细胞瘤。

The mean tumor olume at the time of GKS was 2.5 cm3. In 10 cases a tumor specimen was obtained either by open surgery or stereotactic biopsy, securing the diagnosis of pilocytic astrocytoma in fie patients and nonpilocytic astrocytoma in fie others.

开始GKS治疗时的平均体积是2.5 cm3.10例的肿瘤标本通过开放手术或立体定向的活检获得，得出的诊断是：5例毛细胞性星形细胞瘤，5例为非毛细胞性星形细胞瘤。

Part three:Cochlear on Hair Cell Like Cells Regeneration in Presbycusis C57BL/6 Mice after Math1 Gene Inner Ear TransfectionIn order to test the probability of Mathl gene induces hair cell like cells regeneration in cochlea of presbycusis C57BL/6 mice,8 mounths old C57BL/6 mice were used for this study and were microinjected with Ad-MathlorAd-EGFP in the scala tympani by ventral approach.

第三部分老年性聋模型小鼠C57BL/6耳蜗鼓阶外源基因Math1导入后出现毛细胞样细胞现象的观察为了观察老年性聋C57BL/6小鼠(8月龄)耳蜗鼓阶外源基因Math1导入后能否在老年性聋的耳蜗微环境诱导出新生的毛细胞样细胞，为Math1基因治疗老年性聋进行探索性研究。

Now we don't know how aminoglycoside antibiotics damages hair cells, but there are some theories about it, such as:(1)AmAn affects the transformation among phosphoinositoln, inositol- 3-phophate and glycerine-2-acyl, also, it can cause the change of Ca2+ concentration in endocellular.

氨基糖甙类抗生素(aminoglycoside antibiotics， AmAn)损伤毛细胞的机制尚不清楚，但有以下几种学说：(1)影响了磷酸肌醇、三磷酸肌醇、二脂酰甘油间转化从而导致细胞内钙离子浓度的变化；(2)抑制G蛋白和鸟氨酸脱羧酶活性；(3)氨基糖甙类抗生素能引起内耳毛细胞的凋亡。

HBV transplacental transmission route may be realized by cell to cell transfer in placenta, which means that HBVs in maternal blood and/or intervillous space infect DCEC and/or DC and/or TC, then transmit to VMC, then to VCEC, and finally to fetus.

HBV经胎盘感染胎儿的路径可能是通过胎盘细胞至细胞的传递而实现的。即母血和/或绒毛间隙HBV→蜕膜毛细胞管内皮细胞和/或蜕膜细胞和/或滋养层细胞→绒毛间质细胞→绒毛毛细血管内皮细胞→胎儿。

Results The hair-cell-like cells with tufts of microvilli were found on their surface in the damaged organ of Corti at 7 days after stopping of injection.

结果 在外毛细胞损伤区有细胞表面长有微绒毛簇的毛细胞样细胞出现，且其在损伤Croti器中有发生-发展-退化的变化过程。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失