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A method for the simultaneously quantitative determination of contents of aminopyrine and antipyrine by high-performance liquid chromatography was established.

建立高效液相色谱法测定安痛定注射液中氨基林和安替林的含量。

Results: aminopyrine in 20 ~ 200mg · L-1 concentration range of linear relationship, r = 0.9998, average recovery was 100.4%,Diantipyryl in 10 ~ 60mg · L-1 .the concentration range of linear relationship, r = 0.9997, the average recovery was 100.2%.

结果:氨基林在20~200mg·L-1的浓度范围内呈线性关系,r=0.9998,平均回收率为100.4%;安替林在10~60mg·L-1的浓度范围内呈线性关系,r=0.9997,平均回收率为100.2%。

And containing aminopyrine aminopyrine drugs.

氨基林及含氨基林的药物。

Significantly delayed the response time to hot-plate thermal stimulation 15,30,60 and 90 min after treatment,and 90 min after treatment,the effect of PBSM (2.5g/kg) was higher than that of aminopyrine (100 mg/kg i.m.).

结果:热板法中,灌胃三叶委陵菜乙醇提取物(0.5 g/kg,1.25g/kg,2.5g/kg)15,30,60和90min后,小鼠的痛阈均明显延长,其中灌胃2.5g/kg提取物90min后的镇痛效应氨基林100 mg/kg i.m。

In order to study the relation of cytochrome P-450 with the protective action of SY-801 and SY-640 against 〓-induced UDS and 3H-BP binding to nuclear DNA, the effects of SY-801 and SY-640 on liver microsomal cytochrome P-450 were studied in mice. The results indicated that the liver microsomal cytochrome P-450 concentration and aminopyrine demethylase activity were significantly increased in mice pretreated with SY-801 150mg/kg or SY-640 150 mg/kg once daily for three days.

本实验进而观察了SY-801对小鼠肝微粒体细胞色素P-450酶系的影响,结果表明SY-801和SY-640体内连续给药3天,可诱导小鼠肝微粒体细胞色素P-450含量明显增加,同时氨基林脱甲基酶活性亦明显增加;给药1次2小时内二者均可抑制氨基林脱甲基酶活性,而对肝微粒体细胞色素P-450含量则无明显影响。

Mehtod: animals were given intraperitoneally normal saline(10ml/kg.d), phenobarbital (40mg/kg.d) and puerarin (100, 200mg/kg.d) respectively for seven days. Then the levels of hepatic microsomal CYP and cytochrome b5(Cytb5), and the activities of aniline hydroxylase and aminopyrine N-demethylase were determined by spectrophotography.

实验动物分别腹腔注射生理盐水、苯巴妥(40mg/kg.d)、葛根素(100和200 mg/kg.d),给药7d后,用分光光度法测定肝微粒体CYP和细胞色素b5(Cytb5)的含量,以及苯胺羟化酶和氨基林N-脱甲基酶的活性。

Mehtod: The animals were given intraperitoneally normal saline(10ml/kg.d), phenobarbital (40mg/kg.d) and puerarin (100, 200mg/kg.d) respectively for seven days. Then the levels of hepatic microsomal CYP and cytochrome b5(Cytb5), and the activities of aniline hydroxylase and aminopyrine N-demethylase were determined by spectrophotography.

实验动物分别腹腔注射生理盐水、苯巴妥(40mg/kg.d)、葛根素(100和200 mg/kg.d),给药7d后,用分光光度法测定肝微粒体CYP和细胞色素b5(Cytb5)的含量,以及苯胺羟化酶和氨基林N-脱甲基酶的活性。

For example: antimalarials primaquine morpholine, flutter malaria quinoline, quinine, chloroquine, quinacrine; antibacterial drugs have sulfa drugs, chloramphenicol and furans; antipyretic analgesics are acetyl salicylic acid, phenacetin, acetanilide, antipyrine, aminopyrine; other drugs such as vitamin K, probenecid, hydralazine, quinidine, methylene blue, toluene and so on.

抗疟药伯氨喹啉、扑疟喹啉、奎宁、氯奎、阿的平;抗菌药有磺胺类药物、氯霉素及呋喃类;解热镇痛药有乙酰水杨酸、非那西丁、乙酰苯胺、安替林、氨基林;其它药物如维生素K、丙磺舒、肼苯哒嗪、奎尼丁、美蓝、甲苯等。

It is very similar to traditional N fertilizers used often to physical and chemical quality of soil,amm...

但废液中有机态氮的水解以及向硝态氮的转化尿素要快一些。尿素和BST硫酸铵更适于在红壤和沙质灰土上施用。

The test indicates that reaction temperature is higher, reaction time is longer and nitrogen content is lower than those when technical lignin material is used. Efficiency of ammonification with peroxide of hydrogen as an oxygenant is higher than that with oxygen as an oxygenant.

实验表明天然木质素原料氨化的反应温度工业木质素高,反应时间较长,氨化产物的含氮量较低(含氮量为3.9%-6.7%;用过氧化氢作氧化剂用氧气作氧化剂,氨化效率高。

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