毒素

Coli Min27 strain with mitomycin C. Twenty-one E. coli strains with various serotypes were infected with FMin27, and plaque formation and lysogenic conversion of them were investigated.

用丝裂霉素对该突变菌株进行诱导，结合抗性标记和PCR方法筛选出一株突变的志贺毒素2型噬菌体，命名为FMin27。

It has been found recently that the toxin gene ctxAB is carried by the lysogenic bacteriophage CTXΦ. The possibility in theory exists that the vaccine strain could reacquire ctxAB from a wild-type strain in the intestine or in the environment by horizontal transfer of CTXΦ.

但是，毒素基因ctxAB由溶原性噬菌体CTXΦ携带，可能在偶尔的情况下水平转移给减毒活菌苗，给其在现场应用的安全性带来了重大隐患。

Pseudomonas cocovenenans subsp farinofermentans-bacterium responsible for some food poisoning, were first isolated from fermented corn in the North-east of China in 1977. The studies were conducted in our laboratory during the last decade on the antigen structure, identification methods for the bacterium by biochemical techniques and the characteristics of Bongkrekic acid, including structure, inducing machinism and curing method of the toxin.

椰毒假单胞菌酵米面亚种是我国学者于1977年在东北酵米面中毒食物中发现的一种新的食物中毒菌，我们曾对其菌体抗原结构，生化鉴定和检测方法以及其产生的毒素-米酵菌酸的结构、产毒机制和消毒、去毒等方面进行了深入的研究。

Results Women were more often affected than men(1.83:1) and 53 patients were older than 40 years. The involved parts were as follows: eyelid 58 cases (89.2%), mouth and mandibula 46 cases(70.8%),neck 17 cases(26.2%). The symptom at onset were blepharospasm 42 cases(64.6%) or oromandibular dystonia 17 cases(26.2%).In part of the patients, cranial MRI examination could find focus in brainstem or basal ganglia. Among 37 patients treated with oral drugs, 4 cases were almost cured, 16 cases improved and 17 cases showed no effect. While in 15 patients treated through chiostridium botulinum toxin injection, 5 were almost cured, 9 improved and 1 had no effect.

结果 男女患病比率为1：1.83，40岁以上发病53例，受累部位依次为眼睑58例（89.2%）、口-下颌46例（70.8%）、颈部17例（26.2%）；首发症状以眼部不适、眼睑痉挛最多（42例，占64.6%），口-下颌肌张力障碍次之（17例，占26.2%）；14例行头MRI检查者8例发现脑干或基底节区病灶；口服药物治疗37例，显效4例，有效16例，无效17例；15例行肉毒毒素局部注射者显效5例，有效9例，无效1例。

The involved parts were as follows: eyelid 58 cases (89.2%), mouth and mandibula 46 cases(70.8%),neck 17 cases(26.2%). The symptom at onset were blepharospasm 42 cases(64.6%) or oromandibular dystonia 17 cases(26.2%).In part of the patients, cranial MRI examination could find focus in brainstem or basal ganglia. Among 37 patients treated with oral drugs, 4 cases were almost cured, 16 cases improved and 17 cases showed no effect. While in 15 patients treated through chiostridium botulinum toxin injection, 5 were almost cured, 9 improved and 1 had no effect.

结果 男女患病比率为1：1.83，40岁以上发病53例，受累部位依次为眼睑58例（89.2%）、口-下颌46例（70.8%）、颈部17例（26.2%）；首发症状以眼部不适、眼睑痉挛最多（42例，占64.6%），口-下颌肌张力障碍次之（17例，占26.2%）；14例行头MRI检查者8例发现脑干或基底节区病灶；口服药物治疗37例，显效4例，有效16例，无效17例；15例行肉毒毒素局部注射者显效5例，有效9例，无效1例。

Meige syndrome are found more often in female seniors. Myodystonia is likely to involve eyelid, mandibula and neck. Cranial MRI is of diagnostic significance to some extent. Botulinum injection is more effective than oral drugs.

Meige综合征好发于中老年人，女性多见，肌张力障碍最常发生于眼睑，其次为口-下颌、颈部，头MRI有辅助诊断价值，肉毒毒素局部注射较单纯口服药物疗效好。

The toxin is a secondary metabolizable production in the pathogenic process of many pathogens,which can cause necrotic spot of the host. So it is a poisonous factor and it is important to the pathogenic activity.

毒素是许多亲和性植物病原菌致病过程中产生的次生代谢产物，离体使用可造成相应的寄主表现坏死斑反应，因此是病原菌的毒性因子，对决定病原菌的致病性有很重要作用。

The inhibitory effect of GABA could be blocked by GABAAreceptor antagonist bicuculline bicuculline methiodide and Cl- channel blocker picrotokin.

GABA的抑制效应大部分可被GABAA受体选择性拮抗剂荷苞牡丹碱甲基碘化物和Cl-通道阻断剂印防己毒素所阻断，而单独灌流BMI和PTX对RVLM神经元主要起兴奋作用。

Most recently the group is mainly engaged in some important protein related to health and diseases, including human Cul3 ubiguitin ligase complex, some effectors and eritical proteins of pathogenic bacterical, and a series proteins critical in aromatic degradation pathway of microbal.

近年来的主要研究对象为一些与天然免疫相关的重要蛋白，包括一系列天然神经毒素，抗微生物蛋白，抗肿瘤蛋白和抗病毒蛋白，以及还开展了造血干细胞和痢疾杆菌的结构基因组学研究。

This is the web page of Microbial Toxins: Molecular and Cellular Biology.

这是微生物毒素：分子与细胞生物学的网页。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。