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One hand mechanical obstruct led to the increase of veinous resistance and the obstacle of microcirculation, the other hand the adhesive PMN was activated in excess, the white blood cells released a lot of enzymes, in which PMN-elastase can decompose the components of cell and many albumens, inclusive of immunoglobulin、alexin and fibrication. These components induced the injury of the pancreatic capillary vessels and cell and lysosome enzy made the tissue protein hydrolyze and produced unsaturated fatty acids, which destroyed the structure and function of cellar membrane. The inflammatory cellar factors activate other immunocytes to produce the injury and necrosis of tissue, which aggravated the pathological injury and led to shock、pyaemia and MODS. So ICAM-1 and LFA-1 played an important role in SAP. Frossard found that the expression of ICAM-1 in the rat model, especially in serum、pancreas and lung. All these showed ICAM-1 is an important factor in AP and concomitant lung injury.

胰腺小叶组织局部血管EC首先被激活,ICAM-1表达升高,与被激活的PMN表面表达的LFA-1相结合,"PMN-EC"相互作用加剧,一方面机械性阻塞毛细血管导致静脉阻力增加、微循环障碍;另一方面粘附的PMN过度吞噬或激活,当白细胞吞噬的颗粒不能被封闭隔离,连同细胞内的酶被释放出来,其中的PMN-elastase能够降解细胞基质中各种成分,水解多种蛋白,加重胰腺的毛细血管内皮细胞和腺泡的损伤;释放的溶酶体酶使组织蛋白水解,产生的不饱和脂肪酸引发脂质过氧化方应,破坏细胞膜的结构和功能;释放的炎性细胞因子,激发其他的免疫细胞的功能,导致进一步的组织损伤和坏死,加重SAP的病理损伤,最终导致休克、脓毒血症及多器官功能障碍等严重后果。

Blood were obtained for blood RT and plasma endotoxin concentration check. 6 All data underwent ANOVA analysis. Results: After 3hrs of LPS injection, 1 in hypermetabolic sepsis group, the average HR went to 334/min, the average body temperature went to 41.0℃, while in control group they were 274.9/min and 38.2℃ respectively. p=0.000, presented significant statistical differences. The average BP and breath rate in HS group were 97.1mmHg and 94.3/min , while they were 95.9mmHg and 76.4/min in control group, respectively presenting no statistical differences. 2 In HS group plasma endotoxin concentration was 0.088EU/ml while it was 0.013 EU/ml in control group presenting statistical significance, p=0.002. 3 Blood white cell ratio and total white cell counting were 82.73% and 1.90×109 in HS group, while they were 64.39% and 7.58×109 in control group presenting very significant statistical differences(p=0.001). There was no statistical significances in RBC counting and hemocrit between two groups.

结果:LPS持续灌注3h后,结果如下:1)高代谢脓毒症组的心率升高至334.0次/min、体温升高至41.0℃,而对照组则分别为274.9次/min和38.2℃,两组间有显著的统计学差异,p=0.000;血压在高代谢脓毒症组是97.1mmHg,而对照组为95.9mmHg,两组间无统计学差异;脓毒症组的呼吸加快至94.3次/min,对照组则提高至76.4次/min,两组间无统计学差异(p=0.212);2)其血浆内毒素含量为0.088EU/ml,而对照组为0.013 EU/ml,两组间有显著的统计学差异,p=0.002;3)血中性粒白细胞比值升高至82.73%,对照组则为64.39%,两组间有显著的统计学差异(P=0.001);白细胞总数则明显下降至1.90×109/ml,而对照组则为7.58×109/ml,p=0.001,两组间有显著的统计学差异;两组间的红细胞数及血细胞比容均无统计学差异。

The main raw materials: Dragon's blood, Crocus sativus, catechu, Bidens, Houttuynia, cassia Features: Skin-dimensional Herbalife follow the principle of combination of Chinese medicine, scientific formula to blood circulation, mainly to stop bleeding myogenic the Dragon's blood, with open-end West San Yu Honghua Baidu and anti-cancer, the convergence of bleeding children Supplemented by tea, combined with heat-clearing and detoxifying, eliminate drainage carbuncle, in Tonglin diuresis Houttuynia promoting blood circulation and healing, anti-inflammatory detoxification, swelling of expelling wind Bidens, and the purge Runchang cassia, so sore itch Swelling and remove any drug in vitro, which has a combo-dimensional anti-virus treatment and skin sores, bleeding myogenic role, mainly for soft tissue injury, a variety of wounds, insect bites, such as ants Zhu Zheng.

产品特点:维肤康宝遵循中医配伍原则,经科学配方,以活血化瘀、止血生肌的血竭为主,配以散瘀开结的西红花和败毒抗癌、敛止血的儿茶为辅,佐以清热解毒、消痈排脓、利尿通淋的鱼腥草和活血疗伤、消炎解毒、消肿祛风的鬼针草,并用润肠通便的决明子,使疮痒肿毒及时排除体外,而使维肤康宝具有杀毒疗疮、生肌止血的作用,主要用于软组织损伤、各种创伤、蚁虫叮咬等诸症。

Xuebijing Injection has an protection effect on cruor function in sepsis illness.

血必净注射液对脓毒症患者的凝血功能有保护作用。

Methods: 60 patients whose cruor function were normal, divided randomly into two groups. 30 patients in the controlled group received the combination treatment of WM, the other 30 patients in the treatment group received Xuebijing Injection additionly. Observed the change of PT, TT, APTT, FBG and PLT before the therapy and the 1st, the 3rd and the 7th day after therapy.

60例无凝血功能障碍的脓毒症患者随机分为两组,对照组30例给予常规综合治疗,治疗组30例加用血必净注射液治疗;分别检测两组患者治疗前、治疗第1、3、7日凝血酶原时间、凝血酶时间、活化部分凝血活酶时间、纤维蛋白原和血小板计数。

The pathogenesis of anthrax is such that unless antibiotic treatment is initiated at an early stage in the disease , it is ineffective against the bacteria-induced toxaemia that subverts the immune response , inflicts massive tissue damage and is ultimately the major factor contributing to death during anthrax infection .

发病机制中的炭疽热是这种抗生素治疗,除非是开始在早期阶段的疾病,它是无效的细菌引起的毒血症这破坏了免疫反应,造成大量的组织,并最终损害的主要因素期间死亡炭疽感染。

While all antibiotics will affect the gut flora of a guinea pig, some are deadly and can cause a fatal enterotoxemia.

所有的抗生素都会影响豚鼠肠道菌群,有些是致命的,并可能导致致命的肠毒血症。

Hematosepsis patient who had been warned of cutting his affected limb by the American Kaiser Hospital was saved by a special TCM treatment.

疮疡肿毒急治西医确诊急性挤炎达败血危症托毒排脓止痛吸出脓毒5cc转危为安的见证,美国凯撒医院诊断败血症警告要24小时内截肢致残属于中医杂证疮疡肿毒用紫金定加冰片痊愈的见证

One hand mechanical obstruct led to the increase of veinous resistance and the obstacle of microcirculation, the other hand the adhesive PMN was activated in excess, the white blood cells released a lot of enzymes, in which PMN-elastase can decompose the components of cell and many albumens, inclusive of immunoglobulin、alexin and fibrication. These components induced the injury of the pancreatic capillary vessels and cell and lysosome enzy made the tissue protein hydrolyze and produced unsaturated fatty acids, which destroyed the structure and function of cellar membrane. The inflammatory cellar factors activate other immunocytes to produce the injury and necrosis of tissue, which aggravated the pathological injury and led to shock、pyaemia and MODS. So ICAM-1 and LFA-1 played an important role in SAP. Frossard found that the expression of ICAM-1 in the rat model, especially in serum、pancreas and lung. All these showed ICAM-1 is an important factor in AP and concomitant lung injury.

胰腺小叶组织局部血管EC首先被激活,ICAM-1表达升高,与被激活的PMN表面表达的LFA-1相结合,&PMN-EC&相互作用加剧,一方面机械性阻塞毛细血管导致静脉阻力增加、微循环障碍;另一方面粘附的PMN过度吞噬或激活,当白细胞吞噬的颗粒不能被封闭隔离,连同细胞内的酶被释放出来,其中的PMN-elastase能够降解细胞基质中各种成分,水解多种蛋白,加重胰腺的毛细血管内皮细胞和腺泡的损伤;释放的溶酶体酶使组织蛋白水解,产生的不饱和脂肪酸引发脂质过氧化方应,破坏细胞膜的结构和功能;释放的炎性细胞因子,激发其他的免疫细胞的功能,导致进一步的组织损伤和坏死,加重SAP的病理损伤,最终导致休克、脓毒血症及多器官功能障碍等严重后果。

As an adjuvant for the protein vaccine,PoIFN-αinduced strong inflammatory cytokine production in vivo and the results denoted that IFN-adjuvant and our vaccines could drive the immune response toward Th1 type responses.The data of ELISA suggests that the recombinant protein vaccine synergizes with the IFN-adjuvant to produce endogenous IFN in vivo.

在病毒攻击实验中,所有的对照组动物均出现口蹄疫临床症状;然而佐剂和疫苗联合注射组的动物均得到保护,没有发现病毒血症和口蹄部水疱,对该组的病毒非结构蛋白抗体检测表明,攻毒14天后没有发现病毒在动物体内复制。

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