毒毒血症

ObjectiveSevere traumatic patients always had a severe blood loss, for maintaining blood supply of heart and head, the gut would appear ischemic and anoxemia through the mechanisms of intestinal ischemic, reperfusion and release of mediators of inflammation and so on, which could cause functional impairment of intestinal barrier and translocation of intestinal bacterium and endotoxin, accordingly, induce the occur of SIRS (systemic inflammatory response syndrome), sepsis and MODS (multiple organ dysfunction syndrome).

目的严重创伤常伴严重失血，机体为维持心、脑的血供，肠道首先出现缺血缺氧，通过肠道缺血、再灌注、炎症介质的释放等机制，引起肠道屏障功能障碍，肠内细菌及内毒素移位，从而导致SIRS、脓毒症和MODS的发生。

Methods: 60 patients whose cruor function were normal, divided randomly into two groups. 30 patients in the controlled group received the combination treatment of WM, the other 30 patients in the treatment group received Xuebijing Injection additionly. Observed the change of PT, TT, APTT, FBG and PLT before the therapy and the 1st, the 3rd and the 7th day after therapy.

60例无凝血功能障碍的脓毒症患者随机分为两组，对照组30例给予常规综合治疗，治疗组30例加用血必净注射液治疗；分别检测两组患者治疗前、治疗第1、3、7日凝血酶原时间、凝血酶时间、活化部分凝血活酶时间、纤维蛋白原和血小板计数。

Objective To monitor the changes of the expression of CD_(14)~+ monocyte human leukocyte antigen DRin septic patients and evaluate their immunological condition,relationship between severity of illness,prognosis and CD_(14)~+ monocyte HLA-DR.

目的通过研究脓毒症患者静脉血CD14+单核细胞人类白细胞抗原-DR表达百分率的变化，评价患者的免疫状态及与疾病的严重程度和预后的关系。

Objective To explore the relationship between coagulation disorders and severity and prognosis in severe sepsis.

目的探讨重度脓毒症凝血功能紊乱与病情严重度及预后的关系。

Methods The activity of AT-Ⅲ was measured by chromogenic substrate method.

目前有许多证据表明，在由SIRS发展到MODS整个过程中凝血机制异常起到很重要作用，采用活化蛋白-C治疗重症脓毒症也取得

It was confirmed through passive immunization of IgY that healthy nonimmunized rabbits whose weight varied during 2Kg and 2.5Kg were intramuscularinjected with IgY 5.0ml (HI=13log2),they could resist the attact of 1.0ml（HA=9log2） RHDV-RC.

通过IgY的被动免疫保护试验证实，IgY滴度稀释至13log2时肌肉注射体重2Kg-2.5Kg的健康非免家兔5.0ml/只，可抵抗兔病毒性出血症强毒RC株1.0ml(血凝价HA为9log2)的攻击。

The maximum titer of this preparation reached 15log2 by hemagglutination inhibition assay.It was confirmed through passive immunization of IgY that healthy nonimmunized rabbits whose weight varied during 2Kg and 2.5Kg were intramuscularinjected with IgY 5.0ml (HI=13log2),they could resist the attact of 1.0ml（HA=9log2） RHDV-RC.

通过IgY的被动免疫保护试验证实，IgY滴度稀释至13log2时肌肉注射体重2Kg-2.5Kg的健康非免家兔5.0ml/只，可抵抗兔病毒性出血症强毒RC株1.0ml(血凝价HA为9log2)的攻击。

Objective To evaluate the changes in tumor necrosis factorα mRNA expression in peripheral polymorphonuclear leukocyte and tissues after cecal ligation puncture in rats.

目的：探讨外周血中性粒细胞及组织中肿瘤坏死因子αmRNA表达在创伤脓毒症中的作用。

The transition from the systemic inflammatory response syndrome to seere sepsis and septic shock inoles a myriad of pathogenic changes, including circulatory abnormalities that result in global tissue hypoxia.1,2 These pathogenic changes hae been the therapeutic target of preious outcome studies.12 Although this transition occurs oer time, both out of the hospital and in the hospital, in outcome studies interentions hae usually been initiated after admission to the intensie care unit.12 In studies of goal-directed hemodynamic optimization, in particular, there was no benefit in terms of outcome with respect to normal and supranormal hemodynamic end points, as well as those guided by mixed enous oxygen saturation.9,13 In contrast, een though we enrolled patients with lower central enous oxygen saturation and lower central enous pressure than those studied by Gattinoni et al.9 and with a higher lactate concentration than those studied by Hayes et al.,13 we found significant benefits with respect to outcome when goal-directed therapy was applied at an earlier stage of disease.

从全身炎症反应综合征转为严重脓毒症和脓毒性休克牵涉大量发病的变化，包括导致全身性缺氧的循环紊乱。这些发病的变化成为先前结果研究的治疗学目标。尽管这些转变随着时间的流失而逐渐出现，既可以在院外，也可在院内，在结果研究中，干预措施往往在进入ICU之后才启动。特别的，在那些目标导向血流动力学最优化研究中，依照结果，那些以正常或超正常血流动力学为终点的措施未能显示出益处，以混合静脉血氧饱和度为导向的研究同样如此。

Methods 65 Wistar rats were randomly divided into four groups: control group(n=10), sham operation group (n=10),CLP group(n=20),Xuebijing group(n=25). Sepsis model was produced in rats by cecal ligation and puncture.

将65只雄性Wistar 大鼠随机分为正常对照组（10只）、假手术组（10只）、模型组（20只）和血必净组（25只），采用盲肠结扎穿孔术制备大鼠脓毒症模型。

Plunder melds and run with this jewel!

掠夺melds和运行与此宝石！

My dream is to be a crazy growing tree and extend at the edge between the city and the forest.

此刻，也许正是在通往天国的路上，我体验着这白色的晕旋。