毒性

Deafness resulted from medicine is constantly the focus of otology, although the research of its mechanism is ongoing, the aim of preventive and treatment is still unpleasent.

氨基甙类抗生素中毒性耳聋一直是耳科领域的研究重点，对其发病机理的研究报道很多，但仍未能达到指导有效预防和治疗的目的。

Positive inotropic effects and safety margin of milrinone had been compared with ouabain on ailing heart model in cats and guinea-pigs.

在猫和豚鼠戊巴比妥钠心衰模型上比较了米利酮和哇巴因的强心作用、安全范围和心脏毒性。

Toxicity occurs through overdosage with an appropriate product or use of an agricultural product.

当药物过量或使用农用产品时会产生毒性。

The possible mechanisms may be inhibition of overproduction of NO, and reduction the cytotoxicity as free radicals of NO.

其作用机制可能与抑制NO的过量产生，减轻其作为自由基的细胞毒性有关。

Ultimately, vulnerable groups of neurons atrophy and die in a process that may involve excitotoxicity (overstimulation of neurotransmitter receptors on neuronal surface membranes), collapse of calcium homeostasis, inflammation, and depletion of energy and growth factors.

最终在兴奋性毒性（过度刺激神经元上的递质受体）、钙紊乱、炎症、能量和生长因子缺乏作用下，敏感的神经元发生萎缩、死亡。apoE4与Aβ和tau的异常聚集有关，还可能损伤线粒体和其他细胞骨架。Aβ、tau、apoE和synuclein与其他分子相互作用，影响多种神经活动和存活的信号转导途径。

But the embryo in the oviduct was observed to be un-synchronization in development with a proportion of embryo loss.

在低剂量时观察到的强烈生殖毒性应该与TCDD在子宫组织中的蓄积和子宫内敏感的细胞色素P4501A诱导能力有关。

That needs the trace elements enter the reaction of maintaining free radicals metabolism balance which can enhance the activity of anti-oxidate enzyme,the trace elements which can enforce the oxidate of the free radical needed to be reduced.This may decrease or increase the relevent trace elements.

这就需要血液中能增强抗氧化酶活性的微量元素参与到维持氧自由基代谢平衡的反应中，以及减少利用血液中能增强氧自由基毒性作用的微量元素，这就使得血液中相应的微量元素含量减少或升高。

The protective effect of gingerol oxime on cells increased with its concentration decreased.

在一定浓度范围内，姜酚肟能保护PC12细胞免受谷氨酸(5 mmol/L)的影响，但较高浓度时对细胞有一定的毒性。

In addition, NOS activity decreased with the time prolonged in vitro, when oxyhemoglobin, a scavenger of NO, was applied, the NOS activity kept stable. This result above demonstrated that NO can inhibit NOS activity, and it was the inhibition of NOS activity by NO that may be an important protective mechanism to resist the neurotoxicity by Py.

另外，本实验还发现，在体外实验时，一氧化氮合酶活性可随时间的延长而逐渐下降，当向反应体系中加入氧合血红蛋白去除一氧化氮的作用后，则一氧化氮的抑制作用消失，酶活性保持稳定；以上结果表明一氧化氮对于一氧化氮合酶活性具有抑制作用，而且这种抑制作用，可能是机体对抗拟除虫菊酯毒性作用的一种重要保护机制。

Dichlorophenoxyacetic acid (2,4-D), a widely used herbicide, was treated by the ozonization technology in the laboratory.During the 2,4-D ozonization, the main categories of intermediates included chloric aromatics, dechlorinated aromatics and organic acids.Some of these intermediates have relatively high toxicity.Therefore, it is crucial to study the kinetics trend of intermediates diversion.

采用臭氧化高级氧化技术对2，4-D（2，4-二氯苯氧乙酸）污染物进行降解，2，4-D降解过程中会产生含氯芳香中间产物、无氯芳香中间产物和有机酸类中间产物，其中部分中间产物具有较高毒性，因此研究2，4-D臭氧化过程中间产物的动力学变化趋势是非常重要的。

I am accused of being overreligious," she said in her quiet, frank manner,"but that does not prevent me thinking the children very cruel who obstinately commit such suicide.""

客人们在卡罗利娜·埃凯家里，举止就文雅一些，因为卡罗利娜的母亲治家很严厉。

Designed by French fashion house Herm è s, this elegant uniform was manufactured in our home, Hong Kong, and was the first without a hat.

由著名品牌 Herm è s 设计，这件高贵的制服是香港本土制造，是我们第一套不配帽子的制服。