毒性

An all previous dynasties book on Chinese medicine important toxicity to the human body harm degree has divided into greatly poisonously it virulent the small poisonous three levels or adds the micro poisonous level.

中药毒性学领域至今无统一的毒性分级定量标准。历代本草一重要毒性对人体损害程度，将其分为了大毒、有毒、小毒三级，或加微毒一级。

The quantitative structure-activity relationships were established based on the 1-octanol/water partition coefficient and an electronic parameters-lowest unoccupied molecular orbit. The result shows that the highest sensitivity is cell density between three end points, and the toxicity of secondary and tertiary propargylic alcohols is correlation to the position of alkynyl and hydrophobicity, respectively.

本次实验结果可发现三个参数中以Final yield的敏感度是最高的，而二级炔丙基醇类之毒性高低是和其炔基接的位置有一定的关联性，三级炔丙基醇类之毒性则与疏水性的高低有关：疏水性越高其毒性越强。

Both the inducers and inhibitors of CYP3A could affect the formation of pyrrolic metabolites, therefore may affect the clivorine-induced hepatotoxicity. The difference of clivorine- induced hepatotoxicity in racial and sex can be partly attributed to this metabolic difference in racial and sex. This phenomenon is worth to be notice.

这种代谢的种属差异是其在豚鼠、大鼠及人体内毒性的差异的原因，同时Clivorine在大鼠体内还存在着代谢的性别差异，其在大鼠体内毒性的性别差异可能与此有关，这种代谢的种属和性别差异导致毒性差异的现象值得引起重视。

Study the bioactivity of the n-HA/PA66 composite and the effects it would be to body's metabolism of calcium and phosphorus ion in vivo.(3) Study the osteo-conductivity and the ability to repair bone defect of the porous n-HA/PA66 composite and the feasibility use it as the scaffold of bone tissue engineering. Objects and Methods as follows: 1.To evaluate the biocompatability of nano-hydroxyapatite crystals and polyamide composite (n-HA/PA66) with the L929 cells.To proceed the morphological observation and take pictures of L929 cells after 1d,2d,4d,and 7d of co-cultured with extract of n-HA/PA66 ,and direct contact with n-HA/PA66.To determine light absorbtion value of every hole under 500 nm with enzyme linked immunity instrument after 1 d,2 d,4 d,and 7 d of contact of n-HA/PA66 extract with L929 cells,and direct contact with n-HA/PA66.In the meanwhile calculate the relative multiplication rate of cells,and evaluate them by six degree tests for cytotoxicity. To investigate the acute and chronic toxic reaction on the whole body induced by the new nano-hydroapatite crystals and polyamide composite(n-HA/PA66)after implanting in vivo and its effects on partial constitution of animal organs after implanting in vivo,and evaluate the potential and degree of subcuticular stimulation reaction.

本实验主要由以下三部分组成：一、n-HA/PA66 复合材料在动物体内、体外的生物相容性及生物安全性评价二、n-HA/PA66 复合材料植入动物体内的生物活性及近期对机体钙、磷代谢影响的实验研究三、网孔 n-HA/PA66 复合材料作为支架修复兔桡骨节段缺损的动物实验研究主要研究目标及方法如下：参照 GB/T16886.5-1997-ISO 10993-5：1992《医疗器械生物学评价细胞毒性试验体外法》之评价标准和要求，采用规定的 L929 细胞(小鼠结缔组织成纤维细胞)，分别经直接接触和材料浸提液与细胞共培养等方式对 n-HA/PA66 复合材料进行细胞毒性测试，采用细胞形态观察法观察两种细胞各组在 24h、48h、72h、5 天后各时相点的细胞形态学变化，并在显微镜下照相，从而对细胞与材料的生物相容性进行定性评价；同时采用细胞生长抑制法，以酶标仪定量测定评价各组 1，2，4，7 天 L929 细胞的相对增殖率，以定量测定并判别材料对细胞的毒性程度。

The toxity of mercury was closely correlated with its speciation,of which methyl-mercury was the most toxic and the main form existing in biological samples.

汞的毒性与其化学形态有很大的关系，甲基汞化合物是一种危害巨大的毒性物质，在汞的各种形态中毒性最高，并且是生物体中汞的主要存在形式。

Acute toxicity of Hg2+, Cr6+, Cu2+, and Zn2+ and their joint toxicity on 5-day-old Trionyx sinensis juveniles in water temperature at (27.4±1.3)℃ were studied.

中文摘要：以 5 日龄中华鳖稚鳖为实验动物，采用静水停食实验法，在水温(27.4±1.3)℃条件下，开展了Hg2+、Cr6+、Cu2+、Zn2+对中华鳖稚鳖的急性毒性和加和等毒性强度联合毒性试验。

The experimental results show that the distributions of content and toxicity equivalent quantity of PAHs in raw coal are similar to coal gasification but this compositions and contents are different. The rise of coal rank leads to the decrease of the content and TEQ of PAHs in raw coal and the increase of TEQ during coal gasification, while the content of PAHs emission from coal gasification increases first and then decreases with the increase of coal rank. The total PAHs contents generated in coal gasification of some sorts of coals are higher than in raw coal. The types of PAHs formed in coal gasification include undecomposed PAHs in raw coal, pyrosysthensis PAHs, and radical polymerization PAHs at high temperature.

试验结果表明：煤气化前后多环芳烃质量分数和毒性当量质量分数的分布特徵相似，但多环芳烃的组成和质量分数不同；煤化程度增加，原煤多环芳烃质量分数和毒性当量质量分数减小，煤气化多环芳烃质量分数先增后减，毒性当量质量分数与煤化程度呈线性关系；部分煤种气化多环芳烃的质量分数高於原煤多环芳烃质量分数，且煤气化多环芳烃的种类分为原煤未分解的多环芳烃、热解合成的多环芳烃、自由基高温缩合生成的多环芳烃。

Methods: Integrated and disrepaired skins in the rats were smeared with Salicylic AcidPhenol Liniment by the maximum tolerated dose only. The toxic reaction of the animals were observed and recorded continuously from the beginning of using the drug to 7 days, and evaluated by using the general standard of the reaction of skin stimulation in pharmacology. Animals were executed by taking off acanthi and blood was collected to check up the periphery blood routine and serum biochemistry at the end of the observation of the rats. And after the dissection, the pathological change of main visceras, such as heart, brain, liver and kidney were observed with naked eye and pathological slices. The data of this experiment was used to calculate the value of LD50 by using Bliss rule.

观察大鼠完整皮肤及破损皮肤一次性涂抹最大耐受量的小儿水杨酸苯酚搽剂所产生的毒性反应情况，从给药0时起至7 d连续观察记录动物的急性毒性和45 d连续的长期毒性反应，以皮肤刺激反应标准进行评分作毒理等级评价；对存活动物在观察结束时进行高位脱椎处死采血检测外周血常规和血清生化，解剖后裸眼和病理切片观察心、脑、肝、肾等主要脏器的病理变化。

However Chinese native medicine by no means non-toxic its toxic production with concocts blends the amount used and so on concerns.

然而，中药并非无毒，其毒性的产生与炮制，配伍，用量等有关。中药毒性学领域至今无统一的毒性分级定量标准。

However Chinese native medicine by no means non-toxic its toxic production with concocts blends the amount used and so on concerns.

中药毒性学领域至今无统一的毒性分级定量标准。历代本草一重要毒性对人体损害程度，将其分为了大毒、有毒、小毒三。。。

I am accused of being overreligious," she said in her quiet, frank manner,"but that does not prevent me thinking the children very cruel who obstinately commit such suicide.""

客人们在卡罗利娜·埃凯家里，举止就文雅一些，因为卡罗利娜的母亲治家很严厉。

Designed by French fashion house Herm è s, this elegant uniform was manufactured in our home, Hong Kong, and was the first without a hat.

由著名品牌 Herm è s 设计，这件高贵的制服是香港本土制造，是我们第一套不配帽子的制服。