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Based on toxicity mechanism, a QSAR model was established and used to explain the toxicity of organic chemicals to fathead minnow and Photobacterium phosphoreum, which showed good relationships with wide range of organic compounds.

根据毒性机理,从理论上推导出有机物的定量结构—活性方程,并用来解释有机物对呆鲦鱼和发光菌的毒性,成功地阐述了有机物对水生生物的毒性机制,区分了有机物对不同生物的毒性的联系和区别,为有机物生物活性预测提供了新的思路。

The results indicate that the type and number of the substituents affect the toxicity of these compounds directly. A nitro group substitution increases the toxicity of the compounds, and on the contrary, an amido group substitution decreases their toxicity. For multi-nitrobenzenes, the toxicity of the o - or p -substituted nitrobenzene is bigger than that of the m -substituted one.

苯环上取代基的类型、数目和取代位置直接影响到标题化合物的毒性大小,强吸电子基如硝基会降低 Q -NO2和 E LUMO大小,使化合物毒性增强,且邻对位硝基取代的毒性高于间位取代;相反,给电子基团氨基的存在则会使化合物的毒性降低。

The third part of this project is to evaluate the safety of the nutria gland. The assay items will include single dose acute toxicity, multiple dose subacute toxicity and mutagenicity test.

在安全性评估方面,本计画将进行北美巨水鼠腺体之动物毒性试验,含单一剂量急毒性及重覆剂量亚急毒性,以及基因毒性试验。

In single acute toxicity test and joint toxicity test,the acute toxicity and joint toxicity of heavy metals Cu2+ and Cd2+ to paramecium was studied.

方法]通过单一急性毒性试验和联合毒性试验,研究了金属离子Cu2+和Cd2+对草履虫的急性毒性和联合毒性

Based on history retrospective study and modern research, the paper expounded that the developing course of embryo toxicity of traditional Chinese medicine is from cyesis abstinence to inheritance toxicity and reproductive development toxicity, and overviewed the research of active components of traditional Chinese medicine in the domains of inheritance toxicity and reproductive development toxicity.

笔者通过对胚胎毒性中药的历史回顾和研究现状分析,阐述了中药胚胎毒性由妊娠禁忌到遗传毒性和生殖发育毒性的衍变发展过程以及中药有效成分在遗传和生殖发育毒性中的研究概况。

The toxicity of selected compounds and their binary mixtures of sodium dodecyl sulfate with three substituted aromatic compounds to photobacterium phosphoreum was investigated, respectively.

研究阴离子表面活性剂十二烷基硫酸钠和苯酚、硝基苯、甲苯3种取代芳烃对发光菌的单一毒性,以及在等浓度配比条件下,SDS与这3种取代芳烃二元混合体系的联合毒性效应,并采用毒性单位、相加指数、相似性参数和泥合毒性指数进行毒性评价。

A comparative study on the joint toxicity of binary mixtures of anilines to Photobacterium phosphoreum and Daphnia magna

按器官系统分类,可分为神经毒性、眼毒性、心脏毒性、肝脏毒性、肾脏毒性及生殖毒性等。

In this thesis, the acute lethal toxicity to Rana japonica tadpoles, the short-term phytotoxicity to Cucumis sativus and the population growth inhibition toxicity to Tetrahymena pyriformis of selected substituted phenols with multiple mechanisms of toxic action were compared and interspecies correlation was investigated.

本文比较了具有多种毒性作用机制的取代苯酚对两栖动物幼体的急性致死性毒性、对高等植物生长的抑制毒性以及对原生动物—四膜虫的种群生长抑制毒性,探讨了这一类污染物的毒性作用机制,进行了种间相关性研究。

In conclusion, the hepatotoxicity of clivorine is caused by the hepatotoxic pyrrolic metabolites formed in vivo. CYP3A involved in the formation of pyrrolic metabolites and plays a key role in metabolism-induced hepatotoxicity of clivorine.

Clivorine的肝毒性是其在体内形成的肝毒性吡咯代谢物所致,CYP3A参与了肝毒性吡咯代谢物的形成并在clivorine的代谢致毒方面发挥了关键性的作用,因此CYP3A的诱导剂和抑制剂可以影响肝毒性吡咯代谢物的形成,从而影响clivorine的肝毒性

The chief results were summarized as follows: In the toxicities tests to aquatic animal in the room, the results showed that Deltamethrin and Lambda-cyhalothrin, which the actual toxicities in the 24 hours on fish, loaches and tadpoles all are above 100%, were the most high toxicity, and that Chlorpyrifos and Triazophos, which the actual toxicities in the 24 hours on them are bellow 54%, were the more high toxicity, and that Fipronil and Abamectin were relatively safe, which the actual toxicities in the 24 hours on them are 22%, and that Bisultap was completely safe, which the actual toxicities in the 24 hours on them are bellow 4%.

研究结果表明:溴氰菊酯、高效氯氟氰菊酯对水生动物的毒性最高,对鱼、泥鳅、蝌蚪24h急性毒性都为100%,毒死蜱、三唑磷毒性次之,对鱼、泥鳅、蝌蚪24h急性毒性均在54%之上,氟虫腈、阿维菌素较安全,对鱼、泥鳅、蝌蚪24h急性毒性均在22%之下,杀虫双对水生动物最安全,对鱼、泥鳅、蝌蚪24h急性毒性为4%以下。

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Lugalbanda 是神和被崇拜了一千年多 Uruk古埃及喜克索王朝国王。

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