毒基

Celangulins is a novel botanical insecticide from Chinese traditional insecticidal plant, Celastrus angulatus Max.

是我国著名的传统杀虫植物，基于其中杀虫活性成分开发的植物源杀虫剂苦皮藤素已获得了3项中国发明专利，6β-丙氧基苦皮藤素Ⅴ是近年来通过苦皮藤素Ⅴ衍生合成得到的毒杀成分。

The book comprehensively reviews the molecular and cellular biology of the most important microbial toxins with a focus on recent advances in the field, covering topics such as toxin ADP-ribosylation of proteins, toxin inhibition of protein synthesis, modulation of actin cytoskeleton, cytolethal distending toxins, cell-damaging/pore-forming toxins, clostridial neurotoxins, toxins of the immune system, streptococcal and staphylococcal toxins, anthrax toxins, Shiga toxin, Yersinia toxin, mycotoxins, and the regulation of toxin expression, as well as the potential of microbial toxins in bioterrorism.

该书全面评论了最重要的微生物毒素的分子与细胞生物学，重点是这一领域中的最新进展，主题包括蛋白质毒素ADP核糖基化，毒素抑制蛋白质合成，肌动蛋白细胞骨架的调控，细胞致死增加毒素，细胞损伤/孔状毒素，梭菌属的神经毒素，免疫系统的毒素，链球菌和葡萄球菌毒素，炭疽毒素，Shiga毒素，Yersinia毒素，毒枝菌素，和毒素表达调节，以及生物恐怖中微生物毒素的潜在可能性。

Methods: A sepsis model of mice made with cecum deligation and perforation was established,and a radioimmunoassay for FABP and 96-well spectrophotometry assays for myeloperoxidase and superoxide dismutasewhich were related with clearance of free radicals,were used to detect their levels in lung and intestine ho...

建立小鼠盲肠结扎致脓毒症模型，采用放射免疫分析法和96孔分光光度分析法分别检测肺肠组织匀浆液中FABP及髓过氧化物酶、超氧化物歧化酶等与自由基清除相关的酶的水平、同时以HE染色方法观察肺肠组织病理组织学改变。

Arsenic poisoning have magma role to paralysis small blood vessels,mercapto Jimei inhibit the activity of the liver and fat necrosischange Hepatic Lobules Centre, heart, liver, kidney, intestinecongestion, epithelial cell necrosis, telangiectasia.

砒霜有原浆毒作用，能麻痹细血管，抑制巯基梅的活性，并使肝脏脂变肝小叶中心坏死，心、肝、肾、肠充血，上皮细胞坏死，毛细血管扩张。

Arsenic poisoning have magma role to paralysis small blood vessels, mercapto Jimei inh ibit the activity of the liver and fat necrosis change Hepatic Lobules Centre, heart, liver, kidney, intestine congestion, epithelial cell necrosis, telangiectasia.

砒霜有原浆毒作用，能麻痹细血管，抑制巯基梅的活性，并使肝脏脂变肝小叶中心坏死，心、肝、肾、肠充血，上皮细胞坏死，毛细血管扩张。

AIM: To observe the changes in infiltrating macrophagesand extracellular matrix in the kidney in the progressive course of nephrotoxic nephritis.

目的：观察肾毒血清肾炎发病过程中肾组织巨噬细胞浸润与细胞外基质含量的动态变化。

Objective The toxicity and synergism of several commonly used insecticides mixed with Piperonyl Butoxide against the larvae of Culex pipiens pallens collected from fields of three regions in Shandong province were determined for controlling vector mosquitoes by scientifically rational use of insecticides as well as delaying and overcome the occurrence and development of resis-tance.

目的 了解常用杀虫剂与增效剂氧化胡椒基丁醚（S 1 ）混用对山东省三个不同地区现场淡色库蚊的毒力及增效作用。

By comparing the body weight, immune organs index and response of lymphocytes to ConA, to analyze the effect of QKL on immunological system of normal mouse. Delayed type hypersensitivity mouse model was established by stimulation with dinitrofluorobenzene. By comparing spleen index and swelling rate of pathogenetic ear, to illuminate the immunoregulation of QKL in vivo. Polymicrobial sepsis mouse model was induced by cecal ligation and puncture. The cumulative survival rate was observed in QKL and NS groups. Results: QKL had no influence on body weight and spleen index of normal mouse, but it could significantly decrease thymus index and inhibit the immune response of lymphocytes to ConA.

连续皮下注射QKL 5 d，通过检测小鼠体重、免疫器官指数和淋巴细胞对ConA刺激的反应，分析QKL对正常小鼠免疫功能的影响；采用二硝基氟苯诱发小鼠耳朵肿胀，发生接触性皮炎，建立DTH模型，通过比较QKL与NS对照对小鼠脾脏指数和发病耳肿胀抑制率评价QKL体内对小鼠的免疫调节功能；采用盲肠结扎穿孔术后引起的多细菌性腹膜炎，建立小鼠脓毒症模型，通过观察QKL对小鼠存活状况的影响，评价QKL的免疫调节作用。

One critic has described Bukowski's fiction as a "detailed depiction of a certain taboo male fantasy: the uninhibited bachelor, slobby, anti-social, and utterly free", an image he tried to live up to with sometimes riotous public poetry readings and boorish party behaviour.

&某种犯忌的雄性动物的白日梦：不羁的单身汉，嗜毒、反社会、彻底的自由&，一位批评家曾这样描述布可夫斯基的小说。

One hand mechanical obstruct led to the increase of veinous resistance and the obstacle of microcirculation, the other hand the adhesive PMN was activated in excess, the white blood cells released a lot of enzymes, in which PMN-elastase can decompose the components of cell and many albumens, inclusive of immunoglobulin、alexin and fibrication. These components induced the injury of the pancreatic capillary vessels and cell and lysosome enzy made the tissue protein hydrolyze and produced unsaturated fatty acids, which destroyed the structure and function of cellar membrane. The inflammatory cellar factors activate other immunocytes to produce the injury and necrosis of tissue, which aggravated the pathological injury and led to shock、pyaemia and MODS. So ICAM-1 and LFA-1 played an important role in SAP. Frossard found that the expression of ICAM-1 in the rat model, especially in serum、pancreas and lung. All these showed ICAM-1 is an important factor in AP and concomitant lung injury.

胰腺小叶组织局部血管EC首先被激活，ICAM-1表达升高，与被激活的PMN表面表达的LFA-1相结合，&PMN-EC&相互作用加剧，一方面机械性阻塞毛细血管导致静脉阻力增加、微循环障碍；另一方面粘附的PMN过度吞噬或激活，当白细胞吞噬的颗粒不能被封闭隔离，连同细胞内的酶被释放出来，其中的PMN-elastase能够降解细胞基质中各种成分，水解多种蛋白，加重胰腺的毛细血管内皮细胞和腺泡的损伤；释放的溶酶体酶使组织蛋白水解，产生的不饱和脂肪酸引发脂质过氧化方应，破坏细胞膜的结构和功能；释放的炎性细胞因子，激发其他的免疫细胞的功能，导致进一步的组织损伤和坏死，加重SAP的病理损伤，最终导致休克、脓毒血症及多器官功能障碍等严重后果。

Plunder melds and run with this jewel!

掠夺melds和运行与此宝石！

My dream is to be a crazy growing tree and extend at the edge between the city and the forest.

此刻，也许正是在通往天国的路上，我体验着这白色的晕旋。