正常血压的

The results indicated that an increase in BP, HR and the pressor response induced by the dPAG stmulation was caused by physostigmine microinjection without DKJ-21 pretreatment and no any change of BP and HR was observed after physostigmine administration with the pretreatment of DKJ-21. These results suggested that the location of central cholinergic system associated with the mechanism of the incidence of hypertension are mainly locate on the rVLM.

进一步的实验在正常血压大鼠上以DKJ-21预先处理后，由毒扁豆碱(0.4μg/0.1μl/site)微量注射至双侧rVLM引起的升压、加快心率、以及增强防御性升压反应的效应均被阻断，提示应激导致高血压时中枢内胆碱能系统活动异常增强的部位主要在于rVLM。

On the normotensive rat, pretreatment with verapamil (0.25 ug/0.1 ul/site), the blocker of calcium channels, by microinjection into the rVLM bilaterally, not only caused a complete block effect on the elevation of BP, HR and the pressor response to defense stimulation by the subsequent microinjection of physostigmine, glucocorticoid or mineralocorticoid (the same dosage as mentioned above) into the same sites, but also led to a slight reduction on the basal cardiovascular activities to a certain extent.

四、在正常血压大鼠上预先用钙通道阻断剂维拉帕米(0.25μg/0.1μl/site)微量注射至双侧rVLM，不仅能阻断随后在同部位微量注射毒扁豆碱(0.4μg/0.1μl/site)、肾上腺糖、盐皮质激素(分别为40ng/0.1μl/site)所致的升压、加快心率、以及电刺激dPAG诱发的防御性升压反应，而且能引起上述指标不同程度的较弱的降低。

In this context, we have reported recently that the volume of myocardial tissue occupied by perimysial and endomysial collagen was lower in hypertensive patients with HF and depressed ejection fraction, than in hypertensive patients with HF and preserved ejection fraction and normotensive subjects.56 Of interest, the interstitial and perivascular accumulation of collagen fibres was abnormally high in the two groups of patients.

在这种情况下，我们已经说了占用体积perimysial心肌组织人肌内膜胶原水平低的高血压患者用高频和沮丧的射血分数在高血压患者的心力衰竭和保存被罚出场分数与正常血压subjects.56舒张压的利息、间质和血管堆积过高的胶原纤维是在两组病人。

The mesentery arteries of hypertension patient and patient with normal blood tension were used in my study, the ion channel change which might involved in the generation and development of hypertension was investigated further through the comparative studies on the expression of compositive subunit gene of large conduction calcium—activated potassium channels in vascular smooth muscule of mesentery artery, so more experimental datas were provided to elucidate the pathological mechanisms of hypertension.

本课题选取原发性高血压患者和正常血压患者的肠系膜动脉，对肠系膜动脉血管平滑肌大电导钙激活钾通道组成亚单位基因表达进行对比研究，进一步探讨原发性高血压发生发展过程中可能的离子通道改变，为高血压发病机制的阐明提供更多的实验依据。

Microinjection of glucocorticoid or mineralocorticoid (40 or 10 ng/0.1 ul/site) into the rVLM bilaterally caused an increase in BP, HR and the pressor response induced by the dPAG stimulation in the normotensive rat, respectively. Dose-dependence of both drugs was observed on the above effects in three directions. Nevertheless, there was no effect of both drugs on the tachycardiac response induced by the dPAG stimulation.

二、分别微量注射糖、盐皮质激素(40或10ng/0.1μl/site)至双侧rVLM，可引起正常血压大鼠的BP升高，HR加快，以及电刺激中脑中央周围灰质背侧区诱发的防御性升压反应增强，并均呈现出剂量-效应依赖性关系，而对电刺激dPAG诱发的加快心率反应无明显改变作用。

After microinjection of the antagonists of glucocorticoid RU 38486 or mineralocorticoid spironolactone (40 ng/0.1 ul/site, respectively) into the rVLM bilaterally, a decrease in BP, HR and the pressor response induced by the dPAG stimulation was observed in the normotensive rat, and there was no change on the tachycardiac response induced by the dPAG stimulation.

分别微量注射糖、盐皮质激素的拮抗剂RU 38486(40ng/0.1μl/site)或螺旋内酯(40ng/0.1μl/site)至双侧rVLM，则引起正常血压大鼠的BP下降、HR减慢，以及电刺激dPAG诱发的防御性升压反应减弱，对电刺激dPAG诱发的加快心率反应无明显改变作用。

On the normotensive rat, bilateral microinjection of L-arginine (16 n mol/0.1 ul/site), a precursor of nitric oxide into the rVLM, caused a decrease in BP, HR and the pressor response induced by the dPAG stimulation, while microinjection of NG-methyl-Larginine (L-NMMA, 16 n mol/0.1 ul/site), a blockade for NO to form, into the rVLM bilaterally, caused an increase in BP, HR and the pressor response induced by the dPAG stimulation. There was no effect of both drugs mentioned above on the tachycardiac response induced by the dPAG stimulation.

五、在正常血压大鼠，于双侧rVLM微量注射一氧化氮前体(16nmol/0.1μl/site)可引起BP降低、HR减慢、以及电刺激dPAG诱发的防御性升压反应减弱；而于同区微量注射生成一氧化氮的拮抗剂N〓-甲基-L-精氨酸(16nmol/0.1μl/site)则可引起BP升高、HR加快、以及电刺激dPAG诱发的防御性升压反应增强；而上述两药对电刺激dPAG诱发的防御性加快心率反应均无明显作用。

Similarly, after microinjection of glucocorticoid or mineralocorticoid into bilateral rVLM with the pretreatment of DKJ-21, the elevation of BP, HR and the pressor response induced by the dPAG stimulation was abolished, which suggested that adrenal corticoids may exert their effects on the incidence of stress-induced hypertension through their modulation onto the muscarinic recptors in the rVLM.

再进一步的实验表明，以DKJ-21预先处理的正常血压大鼠，由双侧rVLM分别微量注射肾上腺糖、盐皮质激素引起的升压、加快心率、以及增强防御性升压反应的效应也能被全部阻断，提示肾上腺皮质激素在rVLM增强心血管活动以及在应激致高血压发病机制中的作用可能是通过对该部位有关心血管神经元细胞膜上M-受体的调节作用而实现的。

Abstract］ Objective To assess the endothelium-dependent relaxation in patients with essential hypertension or hypertension smokers by color Doppler flow imaging.Methods With intermittent ultrasound imaging and power Doppler imaging,we measured endothelium-dependent relaxing function in 72 subjects 24 of whom with essential hypertension,24 of whom with both hypertension and smokingand the others as normal control.We measured the diameter of the superficial femoral and brachial arteries at rest,during reactive hyperaemia,re-test and after sublingual glyceryl trinitrate for evaluating the endothelium-independent dilatation in subjects.The level of plasma NO,ET,PGI2,and TXB2 were determined.

摘要］ 目的探讨原发性高血压及高血压合并吸烟患者血管内皮依赖性舒张功能的改变方法采用彩色普勒高频超声的间歇成像和能量多普勒成像，对24例原发性高血压患者、24例高血压合并吸烟患者及24例正常血压无吸烟史者的血管内皮依赖性舒张功能，包括静息时血管内径、增加流量引起的血管舒张、硝酸甘油引起的血管舒张等，以及对血浆氧化氮、内皮素、血栓素B2（TXB2）和列腺环素（PGI2）等血管活性物质进行检测并比较分析。

Some of the industry's important products include aspirins, antibiotics, blood pressure lowering medications, cholesterol lowering drugs, Aids cocktails, drugs that slow the progress of breast and prostate cancer and Parkinson's disease, effective sleeping pills, and anti-depressants that enable many mentally troubled persons to live reasonably normal lives.

一些制药产业的重要产品包括阿斯匹林，抗生素，血压降低药物，胆固醇降低药物，艾滋鸡尾酒，以及延缓乳腺癌、前列腺癌、帕金森综合症病情的药物、安眠药、以及使许多精神病患者过上正常生活的镇静剂。

The basic concept of FOP can be summarized as to further optimize effective prescription according to the standard of curative effects and with the aid of modern science and technology and theories of traditional Chinese medicine.

其基本内涵可概括为：以确有疗效的中药复方为研究对象，以现代科学技术和传统中医药理论为技术支持，以该复方所治病证的药效响应为评价标准，以优化重组疗效更优的新复方为研究目的。

Ever since our world has been a world, native forests have been indiscriminately exploited by man.

自从我们的世界一直是世界原生森林被任意剥削人。