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In comparison with healthy comparison participants, major depression showed increased activation in right middle occipital gyrus(BA18), left postcentral gyrus(BA5), left precuneus(BA7) and right hippocampus and decreased activation in middle frontal gyrus when explicit recognition of sad faces.

与健康受试者相比,抑郁症患者明确识别动态悲伤表情时活动增高的脑区包括枕叶皮质(右枕中回,BA18;)、顶叶皮质(左中央后回,BA5;左楔前叶,BA7;),而活动降低的脑区为额叶皮质(左额中回,BA10;)。

The function of precuneus may reflect the semantic matching process.

5楔前叶可能具有语义匹配加工的功能。

Posterior components of the default network, including the precuneus and posterior cingulate, are particularly vulnerable to early deposition of amyloid beta-protein, one of the hallmark pathologies of AD.

默认网络的后组成分,包括楔前叶和后扣带回,特别容易受AD病理学标志之一-淀粉样β蛋白早期沉积的损伤。

In the results of the fMRI experiment,the activation level of picture-word identical matches condition is less than that of the categorical matches and non-matches conditions in precuneus,frontal and occipital areas,which shows repetition inhibition phenomenon.

4fMRI实验结果中,图-词的名字匹配在楔前叶、额区和枕区的激活比不匹配和类别匹配少,表现出重复抑制。

Moreover, during the behavioral judgment task, salient activation of bilateral Precuneus was found when participants judged the actresses' behaviors which were congruent with the gender stereotype rather than the incongruent behaviors.

同时在行为判断阶段,被试对女性模特符合性别刻板印象的行为比违反性别刻板印象的行为显著地激活了双侧顶叶/楔前叶,同样对于男性模特的刻板印象行为判断没有显著区别。

In particular, it is unknown how the relevant neural substrates function as a network to mediate perspective-taking during the task requiring understanding other's belief. The current work first developed a new psychological paradigm that excludes potential confounds such as the processing of language, biological motion, episodic memory and causal coherence in the paradigms used in previous studies. I recorded neural activities associated with mental inference task using functional magnetic resonance imaging and electroencephalography in order to investigate the functional roles of several brain areas (i.e. precuneus, MPFC, etc.) that engage in understanding other's belief. I also proposed a computational model based on the neuroimaging results that simulated the neurocognitive mechanism underlying cortical dynamics in correct judgment of other's belief.

本文首先发展了一个新的心理学实验范式,排除以往常用&错误信念&范式中与语言加工、生物运动、情景记忆及事件连续性和因果性等方面的混淆,采用功能磁共振成像(functional magnetic resonance imaging, fMRI)和脑电(Electroencephalography, EEG)时频分析等脑成像技术,记录与理解他人信念任务相关的神经活动,通过对行为和脑成像数据的分析,研究楔前叶和内侧前额叶等脑区在理解他人信念任务中的功能意义,并根据脑成像结果,提出一个基于自我和他人视角竞争的计算模型,模拟大脑在理解他人信念时做出正确决策时的认知神经机制。

Previous studies have identified that understanding other's mind engages a neural circuit consisting of the medial prefrontal cortex, temporoparietal junction, superior temporal sulcus, temporal pole, and precuneus/posterior cingulated cortex. However, due to the limitation of experimental paradigms and neuroimaging data analysis approach, the exact neurocognitive mechanisms that underlie the understanding of others' belief remain unclear.

尽管前人的研究已发现内侧前额叶、颞顶联合皮层、后扣带回/楔前叶以及颞上沟等脑区参与他人信念理解,但是,由于实验范式本身和脑成像数据分析方法的局限性,过去的研究工作没有提出准确的认知神经机制来解释相关脑区组成的神经网络如何协同工作、完成视角转换以保证正确理解他人的信念。

Using the fMR adaptation paradigm with famous and unknown faces, we show that individuals with congenital prosopagnosia evince normal adaptation effects in VOTC, indicating sensitivity to facial identity, but show no differential activation for familiar versus unknown faces outside VOTC, particularly in the precuneus/posterior cingulate cortex and the anterior paracingulate cortex.

让患者识别知名的和未知的面孔,同时进行功能磁共振适应模式成像,我们发现,先天性面容失认症患者VOTC表现出正常的适应性,表明具有面部识别的敏感性;但是VOTC区以外区域,特别是楔前叶/后扣带皮层和旁扣带回皮层后部,识别熟悉和未知面部时的活化无区别。

A significant negative linear correlation between clonidine concentration and rCBF or spindle activity was observed in the thalamus, prefrontal, orbital and parietal association cortex, posterior cingulate cortex, and precuneus.

统计学分析后,发现在丘脑区、前额叶、眶上回及顶叶联合脑区大脑皮质、背扣带回大脑皮质、楔前叶,可乐定浓度与区域脑血流( rCBF ,即脑电图出现梭形波)呈统计学意义的负线性相关关系。

Results①Compared to NC,PD patients showed decreased positive functionalconnectivity in right dorsolateral prefrontal cortex and bilateral posteriorcingulate cortex related to bilateral STR.In addition,left parietal posteriorcortex (including precuneus,inferior parietal lobule,supramarginal gyrus) showeddecreased positive functional connectivity with L-STR.

结果①PD患者与双侧STR正连接减弱的区域主要位于右侧前额叶背外侧部(dors-olateral prefrontal cortex,DLPFC)和双侧后扣带回皮质(posteriorcingulate cortex,PCC),此外,左顶叶后部皮层(左侧楔前叶、顶下小叶、左侧缘上回)显示与L-STR正连接减弱。

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