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The physical risk identification task, however, resulted in stronger sustained activity in the right cuneus/precuneus and increased transient activation in bilateral amygdala.

但是身体风险识别任务导致在右侧楔叶/楔前叶的持续激活以及在双侧杏仁核的短暂活动。

The decreased ReHo is distributed over left occipital lobe, left cuneus, left precuneus, left lingual gyrus and right frontal lobe, right middle frontal, right gyrus, right frontal Lobe, right inferior frontal gyrus and right precuneus.

ReHo增高的脑区广泛分布于左侧枕叶、楔叶、楔前叶、右额叶、中心前回、额下回、左侧的舌回和右侧顶叶。

Compared to PD-nMCI,decreased gray matter density in PD-MCI was observed in right cuneus,precuneus,bilateral precentral gyrus,right orbit frontal cortex,bilateral midtemporalgyrus and left fusiform gyrus.

相比PD-nMCI组,PD-MCI组右侧楔叶、楔前叶、双侧中央前回、右侧眶额回(orbit frontal cortex,OFC)、双侧颞中回、左侧梭状回灰质密度明显减少。

We didn\'t find activated points in cerebellum and deeper brain.3.Acupuncture of sham point can significantly activated BA2,6,8,13,21,37,40,44,45,47,putamen and other areas.Both the left and right side of the brain have activated points,but points on the right side are more than those on the left.Both sides of middle temporal gyms,parietal lobule,supramarginal gyms and the lentiform nucleus have obvious activated points.The activated points mainly concentrated in the cerebral cortex,the deep-activated are mainly in the putamen.4. Sham needling in sham point can significantly activate BA6, 8,9,10,18,21,37,40,43,44.The activated points are mainly distributed in the right side of the brain.The left side also has some activated points;5.In the comparasion of Acupunture and sham-needling in S J5,we find that BA8 and cerebellum have distinct regional activated points;6.In the comparasion of acupuncture in SJ5 and sham point,we find BA2 and left cerebellar regions have activated points;7.Sham needling in S J5 compared with sham point,we find BA7,8,9,18 and other areas have activated points,the main activated points are at the left brain.It is not difficult to find that the distribution of activated points are mainly in the middle brain,no obvious activated points at the temporal lobe.

结果:通过对数据的处理和分析,我们初步发现:1、外关穴真针刺能显著激活Brodmann area45、37、44、40、22、13、37、47区、海马、杏仁核、黑质等区域,小脑左侧更明显,左侧颞叶皮层激活点多于右侧,且脑部左侧深层激活点多于右侧;2、外关穴假针刺能显著激活BA46、44、41、13、40、37、19区等区域,激活点主要集中表现在大脑皮层,以颞叶为主,小脑及深部未发现明显激活点;3、非穴真针刺组结果分析初步表明,BA2、6、8、13、21、37、40、44、45、47区以及壳核等区域有激活点,大脑左、右侧均有激活点,但右侧更多,双侧颞中回、顶叶下小叶、缘上回及豆状核有明显激活点,激活点主要集中在大脑皮层,深部激活点主要在壳核;4、非穴假针刺能显著激活BA6、8、9、10、18、21、37、40、43、44区等区域有激活点,主要分布在大脑的右侧,左侧也有不少激活点,就其具体分布主要在颞叶和额叶,少部分分布在顶叶和枕叶;5、外关穴真针刺与假针刺对比发现,BA8区和小脑等区域有明显的激活点;6、外关穴真针刺与非穴真针刺对比发现BA2区、左侧小脑等区域有激活点;7、外关穴假针刺与非穴假针刺对比发现,BA7、8、9、18等区有激活点,主要反应点在左侧大脑的枕叶中回、楔叶,顶叶楔前叶及额上回、中回,就其分布不难看出主要在大脑中部,颞叶未见明显激活点。

In comparison with healthy comparison participants, major depression showed increased activation in right middle occipital gyrus(BA18), left postcentral gyrus(BA5), left precuneus(BA7) and right hippocampus and decreased activation in middle frontal gyrus when explicit recognition of sad faces.

与健康受试者相比,抑郁症患者明确识别动态悲伤表情时活动增高的脑区包括枕叶皮质(右枕中回,BA18;)、顶叶皮质(左中央后回,BA5;左楔前叶,BA7;),而活动降低的脑区为额叶皮质(左额中回,BA10;)。

Compared to normal controls, it was found that the hippocampus, temporal pole, frontal lobe, temporal lobe, putamen and precuneus exhibited more significant functional connectivity with posterior cingulate cortex in TLE.

研究发现,与正常对照相比,TLE静息时海马、颞极、额叶、颞叶、壳核及楔前叶等脑区与后扣带回的功能连接增强。

Compared to the controls, the patients exhibited decreased ReHo mainly in the precuneus, medial prefrontal cortex, bilateral middle temporal gyrus and middle frontal gyrus; while the increased ReHo was mainly distributed in the subthalamus.

结果表明:在静息状态下,患者大脑的局域一致性在某些脑区较正常人低,主要集中在楔前叶、内侧前额叶、双侧颞叶、双侧额中回;另外,在某些脑区较正常人高,主要集中在底丘脑等中缝核团。

In particular, it is unknown how the relevant neural substrates function as a network to mediate perspective-taking during the task requiring understanding other's belief. The current work first developed a new psychological paradigm that excludes potential confounds such as the processing of language, biological motion, episodic memory and causal coherence in the paradigms used in previous studies. I recorded neural activities associated with mental inference task using functional magnetic resonance imaging and electroencephalography in order to investigate the functional roles of several brain areas (i.e. precuneus, MPFC, etc.) that engage in understanding other's belief. I also proposed a computational model based on the neuroimaging results that simulated the neurocognitive mechanism underlying cortical dynamics in correct judgment of other's belief.

本文首先发展了一个新的心理学实验范式,排除以往常用&错误信念&范式中与语言加工、生物运动、情景记忆及事件连续性和因果性等方面的混淆,采用功能磁共振成像(functional magnetic resonance imaging, fMRI)和脑电(Electroencephalography, EEG)时频分析等脑成像技术,记录与理解他人信念任务相关的神经活动,通过对行为和脑成像数据的分析,研究楔前叶和内侧前额叶等脑区在理解他人信念任务中的功能意义,并根据脑成像结果,提出一个基于自我和他人视角竞争的计算模型,模拟大脑在理解他人信念时做出正确决策时的认知神经机制。

Two months after a reading invention program based on auditory training, the dyslexic children received another imaging scan using the same tasks. The results showed that the bilateral brain activation of the dyslexic children was significantly higher than the pre-training, especially in the cingulate gyrus (BA23) of bilateral frontal lobe, the bilateral supramarginal gyrus (BA40), the left precuneus (BA7), the right temporal-parietal region (BA22 and BA48) and the right middle frontal gyrus(BA8), suggesting that the activation pattern of the dyslexia for phonological processing gradually changed to that of the normal ones.

阅读困难儿童接受基于听觉和语音的阅读干预训练程序两个月后,再次进行同样任务的脑成像扫描发现,阅读困难儿童双侧脑区的激活都显著高于训练前,尤其是在双侧额叶中扣带回(BA23)、双侧缘上回(BA40)、左侧楔前叶(BA7)、右侧颞顶(BA22和BA48)、右侧额中回(BA8)的活动增强,表现出语音加工过程中大脑功能活动模式逐渐趋向阅读正常儿童的大脑功能模式。

Result: Compared to normal subjects, some functional regions associated with encoding, maintenance and retrieval process showed increased activation in schizophrenia patients, i.e. right precuneus for encoding process, left PMA, left DLPFC, right precuneus and left VLPFC for maintaince process, left PMA for retrieval process. In addition, subcortical structures, primary motor cortex and some verbal regions in left temporal lobe also showed more activation.

结果:与正常组比较,患者组工作记忆不同认知过程的执行脑区激活程度增加,编码期激活增加脑区为右侧楔前叶,维持期激活增加脑区为左侧PMA、左侧DLPFC、右侧楔前叶及左侧VLPFC,提取期激活增加脑区为左侧PMA,而且患者组还激活了更多皮层下结构、初级运动皮层及左侧颞叶语言相关脑区。

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