棘细胞

Several huge erythematous plaques with verrucous surface were noted over the lower limbs. Squamous cell carcinoma was suspected clinically and skin pathology revealed only hyperkeratosis and acanthosis.

我们同时发现病人於下肢出现红色疣状突起的巨大斑块，临床上怀疑是鳞状细胞癌，而切片结果为角质增厚及棘层变厚。

Histological type: of the 25 cases, 14 were endometrioid carcinomas, 2 were clear cell carcinomas, 2 were adenoacanthoma, 1 was serous papillary adenocarcinomas, 6 were mixed epithelium tumor of ovary.

病理类型为子宫内膜样癌14例，透明细胞癌 2例，腺棘癌 2例，浆液性腺癌 1例，混合性卵巢上皮性癌 6例，镜下均可见良性的异位子宫内膜向恶性移行的证据。

The median patient age was 41 years, 1 female and 3 male. The patients received BMSCs infusion at a dose of (1.0-2.0)×107 cells every time by intrabone marrow injection from the anterosuperior iliac spine and BMSCs from the same donor for the same patient were infused more than once.

骨髓间充质干细胞髓内注射具体方法：取右髂前上棘为穿刺注射点，注射骨髓间充质干细胞悬液，4例患者的给药剂量基本控制在(1.0~2.0)×107个细胞/次，行间断多次给药。

METHODS: 10 mL bone marrow was extracted from dog posterior superior iliac spine, heparin anticoagulation, diluted using Hanks juice, treated with 1.077 g/mL Ficoll solution 3 mL, and centrifuged at 2 000 r/min for 20 minutes. Karyocytes were absorbed to form white cloudlike layering interface, and then centrifuged twice using DMEM supplemented with fetal bovine serum, incubated at 12×104/cm2 at 37 ℃ in a 5% CO2 incubator.

于犬髂后上棘抽取骨髓液10 mL，肝素抗凝，Hanks液稀释后，加入1.077 g/mL Ficoll液3 mL，2 000 r/min离心20 min，吸取有核细胞形成白色云雾状的分层界面，用含胎牛血清的DMEM离心2遍，按12×104/cm2密度接种，于37 ℃、体积分数为5%的CO2培养箱内培养。

Results There were significant overexpressions of Bc-X in all layers of epidermis, inflammatory cells and vascular endothelia in dermis; there were mild up-regulations of Bax expression in stratum granulosum and stratum spinosum in the lesional skin.

结果 银屑病皮损中，Bcl-X在表皮各层、真皮炎症细胞及血管内皮的表达均较正常明显增高；Bax在颗粒层与棘层的表达轻度增高。

There were significant overexpressions of Bc-X in all layers of epidermis, inflammatory cells and vascular endothelia in dermis; there were mild up-regulations of Bax expression in stratum granulosum and stratum spinosum in the lesional skin.

银屑病皮损中，Bcl-X在表皮各层、真皮炎症细胞及血管内皮的表达均较正常明显增高；Bax在颗粒层与棘层的表达轻度增高。

By means of the electron microscopic enzymo cytochemistry, it was observed that the activity of acid phosphatase was localized on the autophagic vacuole, the enzyme reaction granules gather to form the vacuolar bodies of various shapes in the cytoplasmic region of the osmiophilic and paraglycogen granules in resting Stylonychia mytilus .

该文应用电镜酶细胞化学方法显示，贻贝棘尾虫休眠包囊中，在胞质嗜锇粒和拟糖原粒区，酸性磷酸酶反应颗粒聚集于具有消化泡作用的泡状体上，葡萄糖 6 磷酸酶反应也定位在自噬泡膜位置。

New antifungal agents have been developed over the past years based on the discovery of many new target sites of Candida albicands. For example, Echinocandins, aiming at the cell wall of Candida albicands, showed strong antifungal activities to fluconazole resistant candidas and fungal biofilm. Moreover, because β-glucan synthase does not exist on the cell membrane of mammalian cells, Echinocandins has a low toxicity and a promising clinical future. Though the mechanism of Histatin is not clear, it has strong activity not only on candida resistant of polyene and azole, but also to Candida parapsilosis, Candida krusei and Cry ptococcus neoformans. Berberine and Ocimum gratissimum L. were also found to have prominent anti-fungi activities.

近年来相继提出了许多抗白念珠菌药物作用的新靶点并成功开发出一些活性强大，疗效确切的抗真菌药，如以真菌细胞壁为靶点开发出棘白菌素类药物卡泊芬净、米卡芬净等，该类药物主要抑制β-葡聚糖合成酶，体外对氟康唑耐药的念珠菌属及真菌生物被膜表现出强大的抗菌活性，又由于β-葡聚糖合成酶在哺乳类动物细胞内不存在，故具有高效低毒的临床效果，是一极具前途的新型抗真菌药；以真菌细胞膜为靶点开发出Histatin类药物，虽然作用机制目前还不完全明了，但其作用不同于临床常用的多烯类和氮唑类，并已经发现Histatin5对两性霉素B和氮唑类耐药的念珠菌有效，并且对非白念珠菌如光滑念珠菌、克柔氏念株菌、隐球菌等也有杀灭作用；通过对植物药物的研究发现黄连素和丁香罗勒Ocimum gratissimum L。

Methods: BMSC were separated from bone marrow of rabbits. Three groups were divided as Group A: CPC combined with BMSC (3ml) and bFGF (100μg/ml), Groups B: CPC with BMSC (3 ml), and Groups C: CPC. Each group was implanted into the sacrospinalis muscle of rabbits after cultured for 24 h.

取兔骨髓，分离骨髓基质细胞，选取松质骨粒型自骨化磷酸钙置於板孔内， A 组复合 BMSC (3ml)和bFGF(100μg/ml)；B组仅复合BMSC(3ml)；C组仅为CPC；置於培养箱中，培养24h后植入兔骶棘肌内。

It suggests that the supraspinous ligaments in the patients with ossification of the ligament flavum also have an obvious tendency of ossification.

结果：胸椎黄韧带骨化症患者棘上韧带内胶原纤维增生、肿胀，出现了大量的纤维软骨细胞，甲苯胺蓝染色呈强异染性。

It has been put forward that there exists single Ball point and double Ball points on the symmetrical connecting-rod curves of equilateral mechanisms.

从鲍尔点的形成原理出发，分析对称连杆曲线上鲍尔点的产生条件，提出等边机构的对称连杆曲线上有单鲍尔点和双鲍尔点。

The factory affiliated to the Group primarily manufactures multiple-purpose pincers, baking kits, knives, scissors, kitchenware, gardening tools and beauty care kits as well as other hardware tools, the annual production value of which reaches US$ 30 million dollars.

集团所属工厂主要生产多用钳、烤具、刀具、剪刀、厨具、花园工具、美容套等五金产品，年生产总值3000万美元，产品价廉物美、选料上乘、质量保证，深受国内外客户的青睐