棘层

Methods The expression of urokinase antigen on the pemphigus organ model was revealed by immunohistochemical method; PA activity was assayed in the acantholysis model; the influence of urokinase on the epidermis was observed by adding purified urokinase into the cultured skin explant.

方法应用免疫组织化学法检测天疱疮器官模型中尿激酶抗原的表达情况；发色底物法测定棘层松解模型中纤溶酶原激活剂的活性；在培养基中加入尿激酶，观察其对表皮的影响。

Neither nail change nor mucosal involvement was noted. The biopsy specimen taken from the thigh showed characteristic acantholysis and dyskeratosis. The clinical and histological differential diagnoses are presented and discussed.

患者无家族史，亦无指甲与粘膜病变，大腿皮肤病灶切片，病理显示典型棘层分解与角化不全，关於临床及病理下类似的鉴别诊断，将在本文中加以讨论。

Several huge erythematous plaques with verrucous surface were noted over the lower limbs. Squamous cell carcinoma was suspected clinically and skin pathology revealed only hyperkeratosis and acanthosis.

我们同时发现病人於下肢出现红色疣状突起的巨大斑块，临床上怀疑是鳞状细胞癌，而切片结果为角质增厚及棘层变厚。

Results among the 128 patients, 71.9% elder than 51-years-old, the lesions of 53.9% of patients located in the exposure sites, such as face and neck. For pathologic feature, six patterns were learned, the most frequent types were hyperkeratosis arid acanthosis. The clinical diagnosis consisted with pathologic diagnosis in 89 cases.

结果 六种类型脂溢性角化病的组织象均可见到，并以棘层肥厚型和角化过度型为主。51岁以上发病者占71.9%，头、面、颈等暴光部位发病者占53.9%，临床和病理诊断特合89例，临床误诊率30.47%。

From the outside to the inside , the body skin is divided into the stratum corneum , stratum lucidum , stratum granulosum , stratum spinosm and stratum basale , after through stratum corneum , stratum lucidum , stratum granulosum , stratum spinosm EGF can reach the stratum basale: accelerate the basal cells prpliferation and differentiation , reverse matured cells' differentiation to make stem cells that will form a " stem cells island " with a certain amount , which accelerate the generation of new cellls , make senescent cells keratinize and shed rapidly , make broken and denatured collagen fibers and elastic fibers repaired , so the skin's elasticity increase , and the wrinkles calm down or disappera gradually .

体表皮由外及里共分为角质层、透明层、颗粒层、棘细胞层、基底层，EGF可以通过透明层、颗粒层、棘细胞层深入肌肤基底层，加速基底层细胞增殖分化，将已经分化成熟的细胞逆分化成干细胞，当达到一定量时，便会形成&干细胞岛&，加速新细胞的生成，让衰老细胞快速角化、脱落，已断裂、变性的胶原纤维和弹性纤维得到修复，皮肤弹性增加，皱纹逐渐平复、消失。

First 27 rabbits of the experimental group were destabilizated by operated on L6、7.Inj Diazepam 0.25 mg/kg,Inj Ketamine 0.02 g/kg and Inj Atropine 0.125 mg/kg was one by one injected into the rabbit through the auris vein,shearing the rabbit hair of backside waist,fixing the rabbit on operation table in face lying,using 1% Povidone Ioding to degerm the operation area.Every rabbit was incised at the backside of its waist,that incisal opening is located in the center of the intervertebral space (L6、7 space) that both side iliac crest line correspond ,from the meso-ordinate direction cut about 4 cm incision,cutting open skin and subcutaneous tissue,thoroughly ,exposing the spinous processes the vertebral plates and the upper-inferior articular processes,entirely segregating the muscles that cohere the spinous processes the vertebral plates and the articluar process,then excising the supraspinal ligaments and interspinal ligaments,biting off two sides the inferior articular processes of L6,in order that resulting in intervertebral destabilization,using 0.9% Inj.Sodium Chloride to washout the incisal opening,in order sewing up each layer tissues.

方法］ 取48只6个月龄日本大耳白兔，雌雄不限，体重为（2.5±0.2） kg，随机进行分组，分为对照组和实验组，对照组为21只；实验组为27只；先将实验组兔腰背部皮毛剪除，用安定注射液1.25 mg/kg、氯胺酮0.02 g/kg、阿托品0.125 mg/kg顺次耳缘静脉注射麻醉后，俯卧固定于手术台上，用1%碘伏消毒手术区域，以髂嵴平对椎间隙（即L6、7）为中心，从正中取一长约4 cm纵行切口，切开皮肤及皮下组织，锐性分离，暴露棘突、椎板及上下关节突，将附着于棘突、椎板及小关节的肌肉全部分离开，然后依次切除L6、7棘上及棘间韧带，咬除第6腰椎两侧下关节突，造成椎间失稳，用无菌生理盐水冲洗切口，依次缝合各层组织；术后动物在笼中自由活动。

Inj Diazepam 0.25 mg/kg,Inj Ketamine 0.02 g/kg and Inj Atropine 0.125 mg/kg was one by one injected into the rabbit through the auris vein,shearing the rabbit hair of backside waist,fixing the rabbit on operation table in face lying,using 1% Povidone Ioding to degerm the operation area.Every rabbit was incised at the backside of its waist,that incisal opening is located in the center of the intervertebral space (L6、7 space) that both side iliac crest line correspond ,from the meso-ordinate direction cut about 4 cm incision,cutting open skin and subcutaneous tissue,thoroughly ,exposing the spinous processes the vertebral plates and the upper-inferior articular processes,entirely segregating the muscles that cohere the spinous processes the vertebral plates and the articluar process,then excising the supraspinal ligaments and interspinal ligaments,biting off two sides the inferior articular processes of L6,in order that resulting in intervertebral destabilization,using 0.9% Inj.Sodium Chloride to washout the incisal opening,in order sewing up each layer tissues.

方法］ 取48只6个月龄日本大耳白兔，雌雄不限，体重为（2.5±0.2） kg，随机进行分组，分为对照组和实验组，对照组为21只；实验组为27只；先将实验组兔腰背部皮毛剪除，用安定注射液1.25 mg/kg、氯胺酮0.02 g/kg、阿托品0.125 mg/kg顺次耳缘静脉注射####后，俯卧固定于手术台上，用1%碘伏消毒手术区域，以髂嵴平对椎间隙（即L6、7）为中心，从正中取一长约4 cm纵行切口，切开皮肤及皮下组织，锐性分离，暴露棘突、椎板及上下关节突，将附着于棘突、椎板及小关节的肌肉全部分离开，然后依次切除L6、7棘上及棘间韧带，咬除第6腰椎两侧下关节突，造成椎间失稳，用无菌生理盐水冲洗切口，依次缝合各层组织；术后动物在笼中自由活动。

Focal acantholytic dyskeratosis with corps rounds and grains were the usual histopathological findings.

局限性棘层松解性角化不良及其产生的圆体和谷粒是最常见的组织病理学改变。

darier's disease is a rare dermatosis with an autosomal dominant mode of inheritance.greasy papules and plaques arise on the seborrheic areas and in the flexures.acantholysis and dyskeratosis are the typical histological findings.

darier病是一种少见的常染色体显性遗传性皮肤病。常在皮脂溢出部位和屈侧皮肤见油腻性丘疹和斑块。棘层松解和角化不良是典型的病理改变。

Results there are 22 affected patients (10 males and 12 females with approximately equal sex ratio) and the mean age of onset was 16 years old.fifteen patients had positive family history.the major symptom experienced was itching.keratotic papules were invariably present in our patients and mixed pattern with seborrheic plus flexural involvement was the commonest phenotypic variation.all of them had acral signs; 36.36% patients had oral mucosal lesions.lesions were most frequently found on face,ears and back of ears,neck.focal acantholytic dyskeratosis with corps rounds and grains were the usual histopathological findings.

结果 22例患者中有女10例，男12例，男女比例基本相当。平均发病年龄16岁。其中15例有家族遗传史。主要的症状是瘙痒。多在皮脂溢出部位和屈侧皮肤可见油腻性角化性丘疹，且全部病例肢端受累，36.36%患者口腔有皮损。最常见部位依次为面部、耳部和耳后、颈部。局限性棘层松解性角化不良及其产生的圆体和谷粒是最常见的组织病理学改变。

Lugalbanda was a god and shepherd king of Uruk where he was worshipped for over a thousand years.

Lugalbanda 是神和被崇拜了一千年多 Uruk古埃及喜克索王朝国王。

I am coming just now,' and went on perfuming himself with Hunut, then he came and sat.

我来只是现在，'歼灭战perfuming自己与胡努特，那麼，他来到和SAT 。