棘

Acanthosis and imperceptible stratum corneum have also been discovered within the epidermis.

表皮层内发现棘皮层增生的现象与不明显的角质层。

The acanthosis nigricans was already there.

这里出现了棘皮病症状

We should doan acth stimulation test and check his skinfor acanthosis nigricans.

应该做一个促肾上腺皮激素刺激测验查一下他的皮肤是否有黑色棘皮症

Acanthosis nigricans presents with gray-brown hyperpigmentation and velvety texture of the skin of the axilla, neck, and over the knuckles.

黑棘皮症患者的腋部、颈部和指节皮肤上有灰褐色色素沉着和天鹅绒样纹理。

Acanthosis nigricans is a hyperpigmentationof the skin .

黑色棘皮症是皮肤的着色过度。。

Dr. Tilson and colleagues developed a screening checklist tool based on the American Academy of Pediatrics and American Diabetes Association guidelines with some modifications. Participating physicians were to screen all children aged 10 to 18 years for elevated BMI. Children with a BMI higher than the 85th percentile were assessed for the risk factors of race/ethnicity, family history of type 2 diabetes, acanthosis nigrans, and hypertension (defined as systolic blood pressure higher than the 90th percentile for age and height).

Tilson医师与同事根据美国小儿医学会与美国糖尿病医学会的治疗指引进行部份修改，研发了一种核对清单；参与的执业医师筛选所有BMI过高的10至18岁儿童，BMI高於前15%的儿童接受筛选种族信仰、第二型糖尿病家族史、棘状黑色素瘤与高血压（以高於同年龄与身高前10%的收缩压来定义）。

And the overgrowth lesions are characterized by epithelial acanthosis, with long, branched rete peg formation, and the excessive accumulation of radiating collagen fibers in the connective tissue layer.

此种疾病在组织学上的特徵为：上皮细胞层数有增厚的发现，并呈现明显的棘状凸出延伸至结缔组织中，在结缔组织中则有大量胶原蛋白堆积而产生纤维化；然而引发牙龈增生的病理机制至今仍不明确。

Acanthosis nigricans has received attention as a type 2 diabetes sign, but Dr. Bennett noted that this dermatologic condition may simply indicate increased insulin resistance. He emphasized that children with type 1 diabetes do have symptoms, while those with type 2 usually do not. Hispanic children, African-American children, and those of Polynesian heritage also seem more vulnerable to developing type 2 diabetes than white children, although obesity and being female clearly increase the risk in all ethnic groups, he said. Currently, there is no direct evidence that physical inactivity, separate from its effect on body mass index, is a risk factor for type 2 diabetes in youngsters.

黑色棘皮病因为是第二型糖尿病的一项病徵而受到瞩目，但Bennett医师表示，这种皮肤疾病可能仅代表胰岛素抗性增加；他强调，这在第一型糖尿病的孩童身上会有此症状，第二型糖尿病则否；他指出，虽然肥胖者与女性在所有种族中有明显地第二型糖尿病增加风险，但西班牙、非裔美国籍以及波里尼西亚人孩童比白人孩童更容易发生；目前没有直接证据证明，来自於缺乏运动对身体质量指数的影响，是造成年轻人发生第二型糖尿病的危险因子。

Acanthosis nigricans has received attention as a type 2 diabetes sign, but Dr. Bennett noted that this dermatologic condition may simply indicate increased insulin resistance. He emphasized that children with type 1 diabetes do have symptoms, while those with type 2 usually do not. Hispanic children, African-American children, and those of Polynesian heritage also seem more vulnerable to developing type 2 diabetes than white children, although obesity and being female clearly increase the risk in all ethnic groups, he said. Currently, there is no direct evidence that physical inactivity, separate from its effect on body mass index, is a risk factor for type 2 diabetes in youngsters.

黑色棘皮病因为是第二型糖尿病的一项病征而受到瞩目，但Bennett医师表示，这种皮肤疾病可能仅代表胰岛素抗性增加；他强调，这在第一型糖尿病的孩童身上会有此症状，第二型糖尿病则否；他指出，虽然肥胖者与女性在所有种族中有明显地第二型糖尿病增加风险，但西班牙、非裔美国籍以及波里尼西亚人孩童比白人孩童更容易发生；目前没有直接证据证明，来自于缺乏运动对身体质量指数的影响，是造成年轻人发生第二型糖尿病的危险因子。

Alstrom syndrome is a rare autosomal recessive disorder associated with early childhood retinopathy, progressive sensorineural hearing loss, truncal obesity, and acanthosis nigricans.

Alstrom症是一种自体陷性遗传的疾病，伴随有幼年型视网膜病变，进行性神经听力丧失，躯干肥胖及黑色棘皮症。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失