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The results of mice sperm anormality test and bone marrow cell micronucleus test showed that transgenic rice have no clearly induced more sperm anormality and bone marrow cell micronucleus.

小鼠精子畸形试验与骨髓细胞微核试验结果均显示转基因工程稻没有明显诱发小鼠精子畸变与骨髓细胞产生微核。

Without anthropogenic radioactivity, the initial 129I abundance of surface reservoir of earth is confirmed as 1.5×10^(-12) that can be used as starting value for calculation of cosmogenic 129I dating.

核试验和核事故释放的129I测定的是现代沉积物年代,测年时间尺度为50a。人们提出人类利用原子能之前地球表层初始129I丰度为1.5×10^(-12),并以该值作为利用宇生129I估算年代的初始丰度值。

Methods Heat circumfluence extraction was adopted to withdraw and isolate Livistona chinensis active principle.The micronucleus tests in mice were carried out.

方法在药效实验跟踪下,从蒲葵子中提取分离抗癌有效成分;采用小鼠微核试验方法对其进行诱变性检测。

The micronuclear frequencies of fetal liver blood were 2.67, 3.33 and 4‰ in treatment group, given intraperitoneally combined NET-OEN at doses of 10, 50 and 100mg/kg, respectively. However, the micronuclear frequencies of bone marrow erythroblasts and fetal liver blood in control group were 1.8~3‰.

作者采用微核试验观察了复方庚炔诺酮对小鼠活体骨髓多染性红细胞及胎肝血微核率的影响,检测其有无潜在的致突变作用,从而为评价复方庚炔诺酮的安全性提供依据。

Results The micronuclear rate in medium dosage group and high dosage group were significantly higher than that of control group(P<0.01). The ratio of sperm malformation in middle group and high group were higher than those of controls (P<0.01).The ratio of sperm malformation increased in dose-dependent manner with dose, a dose-response relationship was found. Conclusion The DBP contamination presents the positive results under the certain dosage to the mouse marrow micronucleus experiment and the spermatozoon abnormal experiment.

结果 中、高剂量组微核率与阴性对照组相比明显升高(P<0.05),且各剂量组微核率随染毒浓度的增加而升高,呈现剂量-反应关系(r=0.937,P<0.01);中、高剂量组精子畸形率与阴性对照组比较差异有统计学意义(P<0.05),且各剂量组精子畸形率随染毒浓度的增加而升高,呈剂量-反应关系(r=0.904,P<0.01),畸形精子中以无钩为最多,其次是香蕉形、尾折叠、双头,分别为4.5%、3.09%和1.32%,结论 DBP染毒在一定剂量下对小鼠骨髓微核试验和精子畸形试验呈现阳性结果。

objective to study the effects of active carbon nanoparticles on the genotoxicity and teratogenicity of mitomycin c.methods using pce micronuclear test, chinese hamster lung cell chromosome aberration experiment and rat teratogenicity, to observe the toxicity of free mmc and the mmc absorbed onto acnp on heredity and reproduction.

目的 检测纳米活性炭对丝裂霉素的遗传毒理及生殖毒理学效应的影响。方法采用小鼠骨髓嗜多染红细胞微核试验、中国仓鼠肺细胞染色体畸变试验及致畸试验对受试物acnp-mmc进行遗传毒性及致畸性检测。

The microkemel and sperm cell abnomalities were analyzed. Results The micronuclear rate in medium dosage group and high dosage group were significantly higher than that of control group(P<0.01). The ratio of sperm malformation in middle group and high group were higher than those of controls (P<0.01).The ratio of sperm malformation increased in dose-dependent manner with dose, a dose-response relationship was found. Conclusion The DBP contamination presents the positive results under the certain dosage to the mouse marrow micronucleus experiment and the spermatozoon abnormal experiment.

结果 中、高剂量组微核率与阴性对照组相比明显升高(P<0.05),且各剂量组微核率随染毒浓度的增加而升高,呈现剂量-反应关系(r=0.937,P<0.01);中、高剂量组精子畸形率与阴性对照组比较差异有统计学意义(P<0.05),且各剂量组精子畸形率随染毒浓度的增加而升高,呈剂量-反应关系(r=0.904,P<0.01),畸形精子中以无钩为最多,其次是香蕉形、尾折叠、双头,分别为4.5%、3.09%和1.32%,结论 DBP染毒在一定剂量下对小鼠骨髓微核试验和精子畸形试验呈现阳性结果。

Methods Using PCE micronuclear test, Chinese hamster lung cell chromosome aberration experiment and rat teratogenicity, to observe the toxicity of free MMC and the MMC absorbed onto ACNP on heredity and reproduction.

目的 检测纳米活性炭对丝裂霉素的遗传毒理及生殖毒理学效应的影响方法采用小鼠骨髓嗜染红细胞微核试验、中国仓鼠肺细胞染色体畸变试验及致畸试验对受试物ACNP-MMC进行遗传毒性及致畸性检测。

Methods Using PCE micronuclear test, Chinese hamster lung cell chromosome aberration experiment and rat teratogenicity, to observe the toxicity of free MMC and the MMC absorbed onto ACNP on heredity and reproduction.

采用小鼠骨髓嗜多染红细胞微核试验、中国仓鼠肺细胞染色体畸变试验及致畸试验对受试物ACNP-MMC进行遗传毒性及致畸性检测。

In order to examine the safety of Evening Primrose Oil Capsule in toxicology, a series of tests are performed, including the acute peroral toxicity test in mice, Ames test, PCE micronucleus test in Bone Marrow cells on mice, sperm abnormality test on mice and 30 days feeding test on rat.

为了探讨其毒理学安全性,本研究利用小鼠急性经口毒性试验、鼠伤寒沙门氏菌/哺乳动物微粒体酶试验、小鼠骨髓嗜多染红细胞微核试验、小鼠精子畸形试验、30天喂养试验等方法对月见草油胶囊进行了食品安全毒理学检测。

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