核网

Key words］ chronic Leukemia;myelofibrosis;reticulin fibre;m egakaryocyte.bone marrow biopsy

关键词］慢性白血病；骨髓纤维化；网硬蛋白纤维；巨核细胞；骨髓活组织检查

The sarcoplasmic reticulum enlarged gradually at 1 day,and it was obvious about the nucleous and under the membrane.

超微结构显示术后1 d心肌细胞肌浆网逐渐扩张，术后5 d尤以核周和肌膜下明显。

At the age of 19 weeks, we have observed ciliated-mucous cells, some cells presented with mucous granules in the supranuclear cytoplasm and a ciliating border with short growing shafts, while the other cells presented with large mucous granules as well as compound cilia.

小粘液颗粒细胞呈柱状，胞浆顶部含有少量球形的粘液颗粒，细胞表面有短小的微绒毛，细胞核大呈椭圆形，胞浆电子密度高，胞浆下部有粗面内质网和线粒体，核上部有高尔基体。

The cell cycle and apoptosis and the expression of P-pg, bcl-2, P53 in the MG63 and MG63/R cell lines were analyzed by flow cytometry. Results The resistance index of the MG63/R cells to cisplatin was 83.557±4.841. The cells also had resistance to doxorubicin, vincristin, methotrexate and cyclophosphamide. Disordered structure of the MG63/R cells was observed through microscopy. The cells appeared in triangle, polygon and polynucleation. The increase of granular endoplasmic reticulums and apophyses was observed through transmission electron microscopy. The proliferation ability of MG63/R increased significantly, with a low apoptosis index.

结果 经顺铂186d的诱导，建立了MG63/R，其对顺铂的耐药指数为83.557±4.841，对阿霉素、长春新碱、氨甲基蝶吟、环磷酰氨亦产生不同程度的交叉耐药；光镜观察可见MG63/R细胞排列不规则，形态呈三角形、多角形及多核现象；透射电镜显示MG63/R细胞表面突起增加，粗面内质网丰富；细胞周期分析显示细胞增殖能力明显增加而细胞凋亡明显降低；MG63/R细胞 P-pg、bcl-2阳性表达较MG63细胞明显增加，P53表达则明显降低。

Firstly, the acute cytotoxicity of profenofos on FG-9307 cells was studied, it was found that the cell growth rate was markedly reduced by profenofos at all the concentrations tested; and that the fine structures of the cells were also altered by profenofos, as evidenced by dilation of nuclear membranes and mitochondria cristae, and presence of enlarged lysosomes with engulfed organelles and numerous vacuoles in the cytoplasm.

丙溴磷对FG-9307的急性细胞毒性研究结果发现：1）在所有实验浓度下，细胞的生长速度均受到抑制。2）细胞的超微结构被丙溴磷所改变，最明显的特征则是线粒体损伤严重，嵴肿胀，部分溶解破裂；核膜肿胀，有溶解；细胞内的电子密度高的溶酶体增多；内质网的膜溶解，核糖体从粗面内质网上脱落下来，游离于胞质中。

Study it looks like there are regions of the brain not directly involved in sexuality that seem to be feminized in gay males.

的差别与性行为方式关系密切，如著名的情绪中枢杏仁核内的神经连接密网。这个重要问题一直没有解决

Bone marrow polychromatic erythrocyte micronucleus rates of jimpy mice fed with different dosage olaquindox was detected by the way of toxicology,and the number of red blood cells,white blood cells and granulofilocyte was mensurated after 30 days.

给小鼠灌喂不同剂量喹乙醇，按毒理学方法检测小鼠骨髓嗜多染红细胞微核率，并在饲养30d后测定血液中红细胞、白细胞、网织红细胞数。

Before treatment,there are abundant microvtlli on the cell surface,many filoplodia on the cell rim,few of endoplasmic reticulums , Golgi complexes and mitochondrions with abnormal structure and lots of free ribosomes in the cytoplasm. The shape of nucleus is irregular with high nuclear-cytoplasmic ratio, many dark pellets of heteromatin and a few of nucleoluses in which there ar...

经1.5×10~2g/L地塞米松处理后，细胞表面微绒毛和丝状伪足显著减少或消失，出现皱褶状和小泡状结构；细胞核形规则，核质比值减小，异染色质团块减少，核仁数目减少、结构致密；细胞质中粗糙型内质网、高尔基体、线粒体数量增多，形态结构典型，游离核糖体减少，这些变化说明地塞米松改变了MGc80-3细胞的超微结构特征，具有明显的诱导分化作用。

The RER, which is studded with polysomes, also seems to be the source of the nuclear envelope after a cell divides.

糙面型内质网，镶嵌在多聚核糖体中，也可能是细胞分裂后核膜的来源。

It is possible to preparing neutralizing MAb which target to active region of Stx2 by synthetical B cell epitope peptides. At present, the crystal structure of the compound of Stx2 and its ligand adenines has been resolved, and the active site of Stx2 is definite, which is the seventy-seventh amino acids, Ganimalon, of Stx2 A1 fragment.

Stx2通过B亚基与受体Gb3结合后，进入细胞，在弗林蛋白酶(一种钙敏感的丝氨酸蛋白酶)作用下A亚基被裂解为A1和A2两个片段，A1片断经内质网进入细胞质暴露毒性活性位点―A1片段发挥N-糖苷酶活性，导致真核细胞蛋白质合成的终止，最终导致细胞的死亡。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。