核小体

In eukaryotes, DNA left-handed chirality by means of histone proteins around octamer to form a stable nucleosome structure.

在真核生物中，DNA按左手手征性的方式，缠绕在组蛋白八聚体的周围，形成稳定的核小体结构。

One of the most important issues concerning investigation of chromatin is how nucleosomes are distributed across genome?

关于核小体的研究中，一个非常重要的问题就是核小体在基因组上的位置是如何分布的？

Each of these bundles is called a nucleosome, and many nucleosomes are bound together by the continuing strand of DNA, which forms a string of beads that further coils to form one of two kinds of chromatin, either euchromatin or heterochromatin.

所有细胞核的最显著的特点就是染色体，由DNA和组蛋白所组成的染色质构成，DNA绕行在由4个相似的组蛋白分子结合而形成的柱状的芯上，这一结构称为核小体，核小体之间由连续的DNA链连接，形成串珠样结构，进一步盘曲形成常染色质或异染色质。

Along the length of the uncoiled chromosomes are beadlike structures called nucleosomes, highly organized aggregations of DNA and histones.

解聚后的染色体呈现一系列核小体相互连接的串珠状结构，核小体是由 DNA 和组蛋白高度有序的结合形成的。

The histone octamer may protect the wrapped DNA from interacting with other environmental factors such as transcription regulating proteins, thus the positioning of nucleosomes along DNA may play important roles in multiple cellular processes including DNA replication, transcription and damage-repair.

由于核小体结构中的DNA缠绕在组蛋白八聚体上，可能影响这些DNA与细胞内的其他蛋白相互作用，从而影响到DNA复制、转录等生物学过程，因此，核小体在基因组上的位置分布可能对基因组功能具有重要的调控作用。

Genomic DNA in eukaryotic cell is organized into nucleosome array and further packaged into higher-order structures. Each nucleosome is composed of a stretch of approximately 147bp DNA wrapping around a histone octamer, and neighbored nucleosomes are connected by linker DNA with length varies from 20bp to 100 bp.

中文摘要真核生物的基因组DNA能够与组蛋白形成核小体结构，这些核小体结构在基因组上线形排列，并进一步折叠成更加紧密和复杂的高级结构。

When chromatin is reproduced, a stretch of DNA already associated with nucleosomes is replicated, giving rise to two daughter duplexes.

体外合成核小体要从考虑自由DNA和组蛋白的组装过程开始，但体内的核小体仅在DNA复制时形成。

Histones play a major architectural role, holding the coiled DNA in supercoils or beads, about 10nm in diameter and consisting of about 170base pairs.

组蛋白与 DNA 非特异性的结合，包装成为核小体，核小体彼此连接形成直径约10nm 的串珠结构，包含170个碱基对。

We also observed that the genomic regions with higher GC content tend to form nucleosome with greater stability.

我们在线虫核小体DNA中观察到的175-nt周期信号与在阴道滴虫基因序列中观察到的120.9-nt周期信号为同一类信号，反应的都是缠绕在核小体上的DNA与位于核小体之间的DNA在核苷酸组成上的不同。

The basic idea of nucleosome positioning, the relation between nucleosome positioning and gene expression regulation, experimental and theoretical works on nucleosome positioning were reviewed in this paper.

文章从核小体定位基本概念、核小体定位与基因表达调控的关系、核小体定位实验研究和理论预测工作等几个方面总结了核小体定位的最新研究进展。

The concept of equivalent rotationally rigidity is offered and the formula of rotationally rigidity is obtained.

主要做了如下几个方面的工作：对伸臂位于顶部的单层框架—筒体模型进行分析，提出了等效转动约束的概念和转动约束刚度的表达式。

Male cats normally do not need aftercare with the exception of the night after the anesthetic.

男猫通常不需要善后除了晚上的麻醉。