核型

Methods: We used a 5075 gene cDNA microarray to examine gene expression in peripheral blood mononuclear cells from two type 2 diabetes patients with distal symmetric polyneuropathy, two type 2 diabetes patients without distal symmetric polyneuro...

采用包含5075个功能已知人类基因的cDNA芯片检测2名2型糖尿病并发远端对称性多神经病变患者，2名2型糖尿病不伴远端对称性多神经病变患者以及2名年龄和性别匹配的正常个体外周血单个核细胞基因表达谱。

Results 7 cases were probably diagnosed as multipe system atrophy, among which 5 cases were MSA-C, 2 cases were MSA-P; 3 cases were progressive supranuclear palsy.

结果 诊断多系统萎缩-C型5例，MSA-P型2例，进行性核上性麻痹3例。

By the nucleophilic substitution reaction of 6-O-tosyl-l,2:3,4-di-O- isopropylidene-a-Z-galactopyranose (3) with some substituted 1, 2,4- triazole-3-thiols (4a ~ 4c) or 1, 2, 3,4-tetrazole-5-thiols (5a~5f), nine 6-S-(substituted triazolyl or tetrazolyl)-l,2 : 3,4-di-O- isopropylidene-a-D-galactopyranoses (6a ~ 6i) were prepared in high yields. Their structures and configurations were analyzed and established by elemental analysis, IR, NMR, MS spectra.

报道了6－O－对甲苯磺酰基－1，2：3，4－二－O－异亚丙基－α-D吡喃型半乳糖（3）与取代的3－巯基三唑或5－巯基四唑4a-4c或5a-5f的亲核取代反应，合成了9个6－S－－1，2：3，4－二－O－异亚丙基－α- D吡喃型半乳糖（6a-6i），通过元素分析，IR，NMR和MS确证了上述化合物的结构，并经分子模型计算进行了其构象分析。

The present study was undertaken to explore the ultrastructural characteristics of synapses, especially the 5 HT ergic and retinal afferent synaptic connections in the hypothalamic suprachiasmatic nucleus of Tupaia belangeri chinensis, the unique native of South Chinas diurnal "primitive stock" which is more close to the Primates.

本研究借助免疫电镜和溃变纤维电镜追踪等技术，探索我国南方特产，昼行动物&灵长类原宗&树鼠句下丘脑视交叉上核的突触，特别是SCN中5－羟色胺（5－HT）能和视纤维传入的突触联系的超微结构特征，结果表明：TBC的SCN主要包含不对称性GrayⅠ型和对称性GrayⅡ型两种突触类型。

Methods: On the basis of cloning the M-TNF c D NA encoding region,the authors constructed mTNFm,which could potentially expre ss on the c ell surface with a uncleavable type of TNF resulting in deletion of the sequence encoding enzymatic cleavage site of TNF-α-converting enzyme.

在克隆M-TNF cDNA的基础上，删除两型TNF转换酶酶解部位的编码序列，构建出mTNFm并测序验证；建立只表达膜型T N F的真核细胞株。

From the present study, it has been demonstrated that CD44 is cleaved subsequently by MT1-MMP and Presenilins in PC-3 Cells, and in turn causes the release of the CD44ICD. CD44ICD translocates into nuclear and may regulate the tumor cells malignant phenotype via NF-κB pathway which plays a critical role in the malignant progression of prostate cancer, interruption of this pathway might contribute to the inhibition of tumor growth and invasion.

本研究表明：在PC-3细胞中CD44分子分别受MT1-MMP和Presenilin1/2的作用，最终导致CD44ICD从膜结合型CD44ΔE的水解释放并转移进核，并可能通过调控NF-κB等转录因子，影响肿瘤细胞的恶性表型。

Chiral SalanCrX complexesa saturated version of SalenCr(ⅢX are designed,and in conjunction with an ionic quaternary ammonium salt or organic strong base can efficiently catalyze the asymmetric,regio-and stereoselective alternating copolymerization of CO_2 with rac-PO at mild conditions to afford isotactic-enriched polycarbonates with～95%head-to-tail linkages and moderate enantioselectivity.

本论文在Salen构型配体的基础上，设计合成了一系列手性Salan型铬配合物，并将其与季铵盐/有机强碱组成亲电-亲核双组分催化体系，在室温下可以有效的催化CO_2和环氧丙烷的不对称交替共聚反应，实现了CO_2和环氧丙烷的不对称交替共聚反应的区域和立体化学控制，得到95%的头尾连接单元和中等光学纯度(对映体过量值ee%≈70%)的全同结构的聚碳酸酯。

Cinnamomea, antrocamphin A was purified from previous ethanol extraction using bioactivity-guided fractionation. As results, the antrocamphin A could significantly inhibit NO and PGE2 autacoids production in LPS-induced RAW 264.7 macrophage cells. Meanwhile, the mRNA and protein expression levels of iNOS and COX-2 were inhibited by antrocamphin A in a dose-dependent manner. Antrocamphin A also reduced the translocation of NF-κB induced by LPS, which was associated with the prevention of the degradation of I-κB, and subsequently decreased p65/p50 proteins level in the nucleus. This is the first report demostrating the A.

接著并以活性为导向的分离策略，从樟芝子实体乙醇抽出物中分离出具抗发炎活性成分antrocamphin A，续利用LPS诱导小鼠巨噬细胞（RAW 264.7）产生发炎的模式，解析antrocamphin A之抗发炎机制，结果证实antrocamphin A确可有效抑制一氧化氮自由基和前列腺素的生成，透过蛋白质表现分析得知，antrocamphin A之抗发炎活性是经由抑制一氧化氮生成酵素和第二型环氧酵素的mRNA表现，进而抑制了一氧化氮生成酵素、第二型环氧酵素和核转录因子-κB等酵素之表现。

In this paper, the upper member of Eh〓, Shuanghe ～ Zhaoao area, Biyang basin, is treated as a case to study outer and iuner configuration of terrigenous sequence, based on the synthetical analysis of seismic, core, welllog and geological data. Using computer simulation technique of quantitative sequence stratigraphy, accommodation diagram, and baselevel analysis theory, the controling factors. formation, and procedure-responsed mechanics of terrigenous sequence are discussed.

文中以双河～赵凹地区下第三系核三〓段为例，综合利用地震、钻井、测井、地质等资料，剖析了泌阳断陷陆相层序外部构型和内部构型；采用定量层序地层学计算机模拟技术、可容空间图解方法及沉积基准面分析原理，探讨了泌阳断陷陆相层序控制因素、形成机理及其过程—响应机制。

Result (1) Signals of L-forms were detected in both cytoplasms and nuclei of HO-8910PM cell culture.

结果 (1)HO-8910PM细胞与金葡菌L型体外共培养后在肿瘤细胞的胞浆及胞核中检测到L型的阳性表达。

I am accused of being overreligious," she said in her quiet, frank manner,"but that does not prevent me thinking the children very cruel who obstinately commit such suicide.""

客人们在卡罗利娜·埃凯家里，举止就文雅一些，因为卡罗利娜的母亲治家很严厉。

Designed by French fashion house Herm è s, this elegant uniform was manufactured in our home, Hong Kong, and was the first without a hat.

由著名品牌 Herm è s 设计，这件高贵的制服是香港本土制造，是我们第一套不配帽子的制服。