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Of the four nucleotides that comprise DNA molecules, adenine, turns out to have a particularly high affinity for gold.

在组成DNA分子的四种核苷分子中,属腺嘌呤与金的亲合力最强。

It has been developed as an anti-hepatitis B virus agent for treatment of chronic hepatitis B virus infection by Bristol-Myers Squibb Company.

恩替卡韦是一种有效的、选择性抑制乙型肝炎病毒复制的脱氧鸟嘌呤核苷类似物,由Bristol MyersSquibb公司研究开发,用于治疗乙型肝炎。

Post-transcriptional modification in which a derivative of guanosine is attached to the 5' end of the pre-mRNA.

将鸟嘌呤核苷的衍生物加到前体mRNA 5'端上去的转录后修饰作用。

MPA was shown to hae a distinct anti-HC mechanism of action, independent of cell proliferation and guanosine depletion.

麦考酚酸表现出一种特殊的抗丙肝病毒复制的作用机制,它不依赖细胞增殖及鸟嘌呤核苷消耗。

The Taohezhenwu Decoction has good curative effect in treating and preventing CRF of rats induced with adenine by improving the renal function, electrolyte disturbances, acid-base equilibrium, hemophthisis and the function of SOD, reducing the harm of NO, TNF-α, and lessening or delaying the deterioration of nephron.

桃核真武汤能改善腺嘌呤大鼠慢性肾衰模型的肾功能、调节电解质酸碱平衡紊乱、纠正贫血、减少尿蛋白的丢失、减少NO与TNF-α损伤、提高SOD的保护作用、一定程度上防止肾单位的恶化,对SD大鼠腺膘呤所致之CRF的防治有肯定的疗效。

A single donor cell was injected into the perivitelline space of enucleated oocyte and fusion was induced with electric pulses. Reconstructed oocytes were activated using ionomycin (5 M,5min) and 6-dimethylaminopurine (6-DMAP,2mM,5h).

将供核细胞注射到去核卵母细胞的卵周隙,经电融合获得重构胚,再经离子霉素(Ionomycin,5μM,5min)和6-二甲基氨基嘌呤(6-DMAP,2mM,5h)处理激活。

The action of dipyridamole conjugating on Panc-1 cell membrane on the intracellular concentration of 6-thiopurine was studied.

考察了作为核苷载体阻断剂的潘生丁对细胞膜上核苷载体转运6-巯基嘌呤的影响。

Results There was an extensive staining with both P2X2 and P2X4 receptors positive neurons and nerve fibers localized in medulla oblongata. It was mainly localization in the nucleus tractus solitarius,Ⅻ nucleus and ventrolateral medulla of medulla oblongata. It also scattered throughout rest of medulla.

结果 P2X2和P2X4嘌呤受体的阳性神经元和阳性纤维在新生鼠和成年鼠的延髓都有广泛表达,主要分布在孤束核、Ⅻ颅神经核和延髓腹外侧区,延髓其他区域为散在的分布。

After overcoming the flux shift during the process, the production ability of strains could be the limiting factor for further increasing the production. To avoid the random modification on strains, the comprehensive enzymatic study of nucleoside producing-pathway was conducted on four strains with different producing ability. And the results could be used to direct further reconstruction of strains. It was also found that nucleotidase was of much importance to nucleoside production.

在成功克服了代谢流的迁移之后,菌株的代谢能力可能成为了进一步提高产率的限制因素,为了避免对生产菌的进一步改造中的盲目性,对四株不同菌株间嘌呤途径关键酶活力的系统测定,对肌苷、鸟苷生产菌种的酶学特征有了全面的了解;并发现了核苷降解酶对于核苷生产能力至关重要;酶学特性研究对肌苷、鸟苷生产菌的进一步改造提供了方向。

Starting from intermediates of L-ribose, we synthesized a series of L-ribosides and their derivatives with the bases of pyrimidines and purines.

同时,我们从合成L—核糖的中间体出发合成了一系列碱基为嘧啶类和嘌呤类的L—核苷及L—核苷衍生物。

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