核体

The observation with histomorphology and phase contrast microscope: osteoclasts were large in size, multinucleus, foam-like cytoplasm with vacuole and pseudopodia, and movable. Acid Phosphatase reaction is positive.

经组织形态学、光镜和相差显微镜观察，破骨细胞具有胞体大，多核，胞浆泡沫状间有空泡，胞浆有伪足样突起，并可移动，酸性磷酸酶反应阳性。

The inhibition on the proliferation depended on the exposure time and dose.The cells showed morphological changes at the early stage of apoptosis under the light microscope:the shrunk and round cells;condensed cytoplasma and pycnosis nucleus and autophasosomes could be found under the transmission electron microscope.

在凋亡早期细胞形态学变化在光镜下可见细胞缩小变圆，在电镜上可见细胞质浓缩、核固缩及自噬溶酶体。4.0μmol/L As2O3作用72h后HT-29细胞凋亡率为25%。

Results:①The amount of human colon carcinoma cell line SW480 treated by quercetin decreased. The morphology of partial SW480 cells was shrunk volume, integrated cell membrane, condensed cytoplasm, pyknotic chromatin, nuclear fragmentation. Apoptotic Corpuscles were found by electron microscope.②MTT colorimetric assay showed quercetin inhibited the growth of human colon carcinoma cell line SW480 in a time- and dose-dependent manner when the concentration of quercetin was 30、60、90μmol/L.③Flow cytometry analysis showed the cell cycle of SW480 cell was restricted in G1/S. G0/G1 phase rate increased and S phase rate decreased with increasing concentration of quercetin and time lasting.④ Zymogram analysis assay showed the secretion of matrix metalloproteinases in human colon carcinoma cell line SW480 treated by quercetin decreased. With increasing concentration of quercetin, the secretion of MMP-2 and MMP-9 decreased.⑤Immunohistochemistry method demonstrated the position expression of Cathepsin-D in SW480 cell was suppressed by quercetin in a time- and dose-dependent manner.

研究结果：经槲皮素处理的人结肠癌SW480细胞数量减少，部分细胞体积缩小，细胞膜完整，胞浆浓缩，核染色质固缩，细胞核碎裂，形成凋亡小体；MTT法检测显示当作用浓度为30μmol/L~90μmol/L时，槲皮素对人结肠癌SW480细胞的生长有抑制作用，其抑制作用随着作用浓度的增加和作用时间的延长而增强；流式细胞学发现槲皮素主要作用于人结肠癌SW480细胞周期的G1/S期，大部分细胞被阻断于S期，随药物浓度的升高和作用时间的延长，G0/G1期细胞比例逐渐增加，S期细胞比例逐渐减少；酶谱分析法检测显示不同浓度的槲皮素能够抑制人结肠癌SW480细胞分泌MMP-2及MMP-9，随浓度的升高，MMP-2及MMP-9的分泌量减少；免疫组织化学法显示不同浓度的槲皮素处理人结肠癌SW480细胞后，Cathepsin-D的表达随药物浓度的升高和作用时间的延长而降低。

After treatment with AT9810,the cell became smallerand condensed,typical signs,such as cytoplasmicconcentration,chromatin agglutination,pyknotic necleus,necleus cleavage,apoptosis corpuscle,was found inmorphological observation.

经AT9810处理后的细胞体积变小皱缩，形态学观察具有典型凋亡细胞的特征：胞浆浓缩，染色质凝集，核固缩、裂解及凋亡小体形成。

While the tissue spaces surrounding a few blood vessels wasAl and Fg positive,no Al or Fg positive cells were observed.In antemortem injurygroup,diffuse subarachnoid hemorrhage,cerebral edema,swelling or pyknotic neu-rons could be observed.The axons showed irregular swelling and disconnection at1～3h,marked swelling and disconnection at 6h,and retraction ball at 15h whichwas more remarkable at 24h after injury.The space between myelin sheaths andaxons was increased at 3～6h after injury.Tortuous and wavelike myelin sheathswhich adhered on axons incompletely,or even peeled off could be found from 15hto 24h after injury.Perinuclear lysis of Nissl bodies began at 24h after injury.Thenumber of GFAP positive cells in cerebrum and brain-stem increased significantlyfollowed by decrease,and then increased again,but the time courses of the changesin different areas of brain were not same.Al and Fg positive neural cells,mainlysurrounded blood vessels,with diffuse or peripherally distributed positive matter incytoplasm could be observed at 0.5h after injury.The number of Al or Fg positivecells and the intensity of immunoreaction increased with the time of injury.The areaof SYN positivity in medulla oblongata and pons decreased notably 3～6h afterinjury,then return to normal levels and continued to 24h after injury.

生前损伤组，可见广泛蛛网膜下腔出血，脑组织水肿，神经细胞肿胀，晚期神经元固缩；伤后1～3h见部分神经轴突不规则增粗、断裂，伤后6h断端膨大，伤后15h可见收缩球，至伤后24h更为明显；伤后3～6h可见部分神经髓鞘与轴突之间的间隙增宽，伤后15h髓鞘明显曲折，不完全附着在轴突两侧，甚至剥脱，持续到伤后24h；核周尼氏体减少在伤后24h才开始出现；同一部位的GFAP阳性细胞数目随损伤时间发生改变，先增多（最早在伤后0.5h），达到高峰后减少，其后又有增多趋势，但不同部位的GFAP阳性细胞数目增减的时间过程不尽相同，同时，大脑中的GFAP阳性细胞数目也有改变；伤后0.5h，可在脑干组织中见到Al和Fg阳性神经细胞，主要位于血管周围，阳性物在胞浆中呈弥散性分布，但部分细胞的阳性物仅分布于靠近胞膜的胞浆中而呈环状，随损伤时间延长，阳性细胞数目增多，反应强度增加；伤后3～6h，延髓及桥脑中的SYN阳性物面积减少，其后恢复到正常水平，并持续到伤后24h。

Fine carbides precipitated from ferrite in 16-6 Cr-Mo, 16-2.5-6 Cr-Ni-Mo, and 16-5-6 Cr-Ni-Mo steels in the early stages of ageing are metastable, during prolonged heating they redissolve and are gradually replaced by χ-phase. Some residual carbides serve as the nuclei of the growing χ-phase. The structure of quenched 16-15-6 Cr-Ni-Mo steel is austenitic, during subsequent heating only M_6C and M_(23)C_6 mixed carbides are precipitated.

在16-6Cr-Mo、16-2.5-6及16-5-6Cr-Ni-Mo不锈钢中，从铁素体内沉淀出来的细小碳化物是一种过渡组织，在x相的成核与长大过程中，它们将不断地进行溶解。16-15-6 Cr-Ni-Mo不锈钢属奥氏体型，在不同温度进行固溶处理，奥氏体都很稳定，在随后的恒温处理过程中，只有碳化物从奥氏体内析出。

The preparation of metastable materials was explored in view of the nucleation and growth kinetics by means of high undercooling and high velocity laser resolidification techniques.

通过深过冷和高速激光重凝技术，从形核和生长两个不同方面探索了块体亚稳相材料的制备技术。

Objective. To determine if viral vectors carrying the gene for brain-derived neurotrophic factor could be used to promote an axonal regenerative response in rubrospinal neurons after an acute cervical spinal cord injury.

目标：本研究在于确定病毒带菌体存在着一种大脑源性神经营养因子的基因，这种基因可以在急性颈髓脊索损伤所致病例中引发红核脊索神经元的轴性再生反应。

Objectie. To determine if iral ectors carrying the gene for brain-deried neurotrophic factor could be used to promote an axonal regeneratie response in rubrospinal neurons after an acute cerical spinal cord injury.

目标：本研究在于确定病毒带菌体存在着一种大脑源性神经营养因子的基因，这种基因可以在急性颈髓脊索损伤所致病例中引发红核脊索神经元的轴性再生反应。

The average contents of phosphrus in alkali feldspars in both comb zone and the first intermediate zone are high, in the range of 0.42-0.22wt%, and gradually increase from 0.21wt% to 0.50wt% as the magma evolves from the third intermediate zone to the core zone. The abnormally low content of phosphrus (＜0.10wt%) in alkali feldspar from the saccharoidal albite zone is considered due to the crystallization of apatites, which gives rise to extreme depletion of phosphrus in residual melt.

阿尔泰3号伟晶岩脉梳状结构带和Ⅰ带的碱性长石具较高P含量(平均值分别为0.42wt％和0.22wt％)，随着岩浆的演化进行，从Ⅲ带到核部带，碱性长石中P含量逐渐增大(平均值由0.21wt％增至0.50wt％)，而Ⅱ带碱性长石中异常低的P含量(平均值为0.08wt％)是该带大量磷灰石矿物饱和结晶，导致残余熔体相中P极度亏损所造成的，而不是晚期出溶的岩浆热液交代形成的。

For a big chunk of credit-card losses; the number of filings (and thus charge-off rates) would be rising again, whether

年美国个人破产法的一个改动使得破产登记急速下降，而后引起了信用卡大规模的亏损。

Eph. 4:23 And that you be renewed in the spirit of your mind

弗四23 而在你们心思的灵里得以更新