柚皮素

Based on the previous literatures, the following major innovation works were carried out in this dissertation:(1) The derivatization reaction conditions of ephedrine and pseudoephedrine with sensitive derivation reagent in aqueous system were studied and two new methods were developed for the assay of them by microemulsion electrokinetic chromatography and micellar electrokinetic chromatography with LIF detection. The sensitivity and analysis times were greatly improved compared with the previous reports;(2) A new method of CZE with indirect LIF detection was developed for the simultaneous determination of six coumarin compounds (esculin, esculetin, isofraxidin, genistein, naringin and sophoricoside) with fluorescein as the probe. The proposed method enlarges the application range of LIF detector, and provides new approach for the analysis of certain compounds difficult to derivatize;(3) Based on the above research, an MEKC with indirect LIF detection method for the simultaneous determination of adenine and guanine in DNA extracts from fungus, maize and soybean was established;(4) A new method for the investigation of the complexes formed between human serum albumin and ampicillin sodium under the simulated physiology conditions using laser light scattering technique was developed.

该论文在综述前人工作的基础上，开展了如下未见文献报道的创新性的研究工作：(1)使用灵敏的衍生试剂对麻黄碱和伪麻黄碱在水体系中的衍生反应条件进行了系统研究，建立了微乳电动色谱-激光诱导荧光检测法和胶束电动色谱—激光诱导荧光检测法测定麻黄碱和伪麻黄碱的灵敏分析新方法，与以前的报道相比，灵敏度和分析时间均有很大改善；(2)使用荧光素钠作为背景荧光试剂，建立了同时分析测定六种黄酮类化合物(秦皮甲素、秦皮乙素、异秦皮定、染料木素、柚皮苷和槐角苷)的毛细管区带电泳—间接激光诱导荧光检测新方法，扩大了激光诱导荧光检测的应用范围，对难衍生化合物的分离分析提供了一种新思路和新途径；(3)以荧光素钠作为背景荧光试剂，建立了一种用于同时测定食品提取DNA中的腺嘌呤和鸟嘌呤含量的胶束电动色谱—间接激光诱导荧光检测新方法；(4)用动态和静态激光散射法研究了模拟生理条件下人血清白蛋白与氨比西林钠盐相互作用所形成的复合物，为药物分子与蛋白质的相互作用、药代动力学等的研究提供了一种新思路。

The oxidation mechanism of synephrine was also investigated;(2) The electrochemical behavior of twelve flavonoids (quercetin, morin, fisetin, luteolin, isorhamnetin, myricetin, hyperoside, quercitrin, puerarin, farrerol, naringenin and hesperidin) was investigated. The method for the determination of flavonoids was developed by using different pulse voltammetry, and the detection limit was in the range of 10-7~10-9 mol/L. This method has been successfully employed to determine the total amount of flavonoids in pericarpium citri reticulatae and quercetin in the spiked human blood plasma samples.

2研究了槲皮素、桑色素、漆黄素、木犀草素、异鼠李素、杨梅素、金丝桃甙、槲皮甙、葛根素、杜鹃素、柚皮甙元和橙皮甙等12种黄酮类化合物在玻碳电极上的电化学氧化行为，建立了测定黄酮类化合物的微分脉冲伏安法，检测限可达10~(-7)～10~(-9) mol/L，并用DPV法测定了陈皮中总黄酮含量和模拟血清中的槲皮素，结果较为满意。

Whereas naringenin had potency to active estrogenic receptor, it did not increase protein expression of eNOS.

柚皮素虽然能激活雌激素受体，但不能诱导eNOS表达的增加，其原因还有待进一步研究。

University of Buffalo - Orange juice, in spite of its high content of simple sugars, seems to be a healthy food for diabetics due to its abundant flavonoids, naringenin and hesperitin, a study by endocrinologists ...

大学水牛城-橙汁的是，尽管其高含量的简单的糖，似乎是一种健康食品，为糖尿病患者由于其丰富的类黄酮，柚皮素和h esperitin，研究内分泌

Naringenin and hesperitin in orange juice may counteract the rise in free radicals and nuclear factor-kB binding caused by sugar consumption.

柚皮素和hesperitin在橙汁可以抵消增加的自由基及核因子-κ约束力造成的食糖消费。

Naringenin and hesperitin in orange juice may counteract the rise in free radicals and nuclear factor-kB binding caused by sugar consumption.

柚皮素和hesperitin在橙汁，可能会抵消上升的自由基和核因子- kB的约束力，所造成的食糖消费。

Objective: To investigate the effect and mechanism of naringenin on human leukemia K562 cell line.

目的：探讨柚皮素对人慢性髓系白血病K562细胞株生长的影响及其作用机制。

Naringenin has a significant inhibitory effect on the growth of K562 cells in vitro, and the cell cycle arrest and the induction of apoptosis may be involved in it.

柚皮素对K562细胞具有明显的增殖抑制作用，这一作用可能是通过细胞周期阻滞和诱导凋亡两种机制实现的。

The first extraction was used to remove most of the chlorophyll and naringenin was obtained in the second extraction.

实验中先对桃叶粉进行一次提取以除去大量叶绿素，再对桃叶粉进行二次提取以提取柚皮素。

In this paper, the enantioseparation of naringenin was firstly studied by using CDMPC chiral stationary phase.

首次在纤维素三(3，5二甲苯基氨基甲酸酯)手性固定相上，对柚皮素进行了对映体分离研究。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。