柚皮素

Objective: To estabilish an RP-HPLC method for the determination of kaempferol, naringenin and quercetin in Euonymus alatus Thunb.

目的：建立同时测定鬼箭羽中降糖活性成分山柰酚、柚皮素及槲皮素含量测定的方法。

Their chemical structures were characterizd on the basis of spectral and chemical evidences to be: Sarracenin (1), 2-methyl-5-hydroxy-7-O-ethyl caffeate chromome (2), Naringenin(3), 2-methyl-5, 7-dihydroxychromome (4), 2-methyl-6-hydroxyl-cinnamic acid methyl ester (5), eriodictyol (6), quercetin (7), Naringenin-7-O-β-D-glucoside( 8 ), eriodictyol-7-O-α-D-glucoside (9), quercetin-3-O-β-D-glucoside(10). In addition, one compound was abtained from the n-butanol frationk, which was finally identified as Morrosiside(11) by spectral and chemical evidences.

以波谱数据及其理化性质鉴定为：Sarracenin(1)，2-甲基-5-羟基-7-O-咖啡酸乙酯色原酮(2)，柚皮素(3)，2-甲基-5，7-二羟基色原酮(4)，2-甲基-6-羟基苯丙烯酸甲酯(5)，圣草酚(6)，槲皮素(7)，柚皮素-7-O-β-D-葡萄糖苷(Naringenin-7-O-β-D-glucoside)(8)，圣草酚-7-O-α-D-葡萄糖苷(eriodictyol-7-O-α-D-glucoside)(9)，槲皮素-3-O-β-D-葡萄糖苷(quercetin--3-O-β-D-glucoside)(10)；另外从正丁醇萃取部位分离得到1个化合物，以波谱数据和文献对照鉴定为：Morroniside(11)。

Several healthy effects of hesperidin and other citrus flavanoids such as naringenin, diosmin, nobiletin, etc, have been described either in vitro assays or in animal and human clinical trials.

橙皮苷和其他柑橘类黄酮的一些健康的作用，如柚皮素，地奥司明，川陈皮素等，无论是在体外实验或动物和人类的临床试验已经说明。

This result indicated that hesperetin and naringenin was distinct to active subtypes of estrogenic receptor.

观察了橙皮素和柚皮素对人脐静脉内皮细胞NO分泌功能的影响。

We can supply monomers, such as Rutin,Baicalin,Amygdalin,Ursolic acid,limonin,?Glycyrrhizic acid, Chlorogenic acid, Paeoniflorin, Gardenoside, Paeonol, Apigenin, Naringin, Naringenin, Astragalus P.E., Soybean Isoflavones, Epimedium Extract and so on.

产品主要有单体（含量90%~98%：苦杏仁苷、柠檬苦素、熊果酸、芍药苷、栀子苷、丹皮酚、芦丁、槲皮素、黄芩苷、黄芩素、芹菜素、绿原酸、甘草酸、柚皮苷、柚皮素；标准提取物：山楂总黄酮、葛根总黄酮、黄芪多糖、枸杞多糖、大豆异黄酮等。

The effect of hesperetin and naringenin on the proliferation of MCF-7, a estrogen receptor positive cell line was evaluated.

雌激素受体拮抗剂ICI182，780和4-羟基-他莫昔芬能够分别完全和部分抑制橙皮素和柚皮素的促增殖作用。

It is concluded naringenin can protect against doxorubicin-induced oxidative damage in normal blood cells.

柚皮素对阿霉素损伤的正常血细胞具有保护作用，其可能机制是柚皮素提高细胞内抗氧化物酶活性同时降低氧化产物含量。

The results show that the best second extraction condition for naringenin was as follows: 7:3 for concentration ratio of methanol and ethanol, 50 for temperature, 5 h for time, and 1:45 for stuff and liquor ratio.

通过实验确定了柚皮素的最佳二次提取条件为乙醇甲醇浓度比7：3、温度为50℃、时间为5h、料液比为1：45，采用分光光度法测得柚皮素平均得率为5.25%。

When removing the endogenous estrogen from culture medium, both hesperetin and naringenin significantly promoted the proliferation of MCF-7 cells.

同时，橙皮素和柚皮素能部分拮抗E_2的促增殖作用，说明橙皮素和柚皮素具有雌激素样活性。

Results: Proliferation of K562 cells was significantly inhibited by naringenin and the IC50 at 24, 48 and 72h were 455, 225 and 175μmol/L respectively. Cell growth inhibition and apoptosis were observed under light microscope and transmission electron microscope. Observation by flow cytometry indicated that K562 cells were blocked in G0/G1 phase of cell cycle in naringenin group, and S phase cells were remarkably decreased. PCNA expression in each treatment group was remarkably less than in control group.

结果：柚皮素对K562细胞增殖有明显抑制作用，作用24，48和72h后的半数抑制浓度(IC50)分别为455，225和175μmol/I；柚皮素处理组细胞在普通光镜和电镜下均见观察到显著的增殖抑制和典型的细胞凋亡形态学改变；流式细胞仪分析证实柚皮素能使K562细胞聚积在G0/Gl期，S期细胞减少；在处理组PCNA的表达显著低于对照组。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。