染色质的

Histone acetylation and deacetylation are crucial in the regulation of gene expression.

组蛋白乙酰化和去乙酰化对基因表达的调控至关重要，基因表达的动态变化将会影响染色质的结构。

Histones, as basic components of nucleosome, are essential to chromatin structure and function.

组蛋白作为核小体的基本组分，是染色质的结构和功能必需的。

Histone H3 methylated at Lys4, which defines euchromatin, was not only distributed across most of the chromosomal landscape but was also present at the centromere core, the site of kinetochore assembly.

标志着常染色质的组蛋白H3－K4甲基化不仅广泛分布在大部分的染色体区域，同时也存在于着丝点的中心位置。

Increased hepatic acetylation of histone H3 in the IUGR offspring might be caused by decreased HDAC1 expression in nuclear protein. This may contribute to the transcription change of some genes in the hepar.

IUGR大鼠肝细胞核中HDAC1蛋白表达降低，引起组蛋白H3的乙酰化水平增高，染色质的表观遗传学变化可能是肝脏某些基因转录调控变化的分子基础。

The molecular mechanism of OIS is related to the formation of heterochromatin and DNA-damage check-point response.

它的发生机制与异染色质的形成以及DNA损伤检测点反应的作用相关。

The origin of such large amounts of constitutive heterochromatin and their role in karyotype evolution and speciation remain a mystery.

如此大量的结构异染色质的来源及其在染色体组型进化和物种形成中的任务仍是一个谜。

In this review, we discussed the consequences of inhibiting histone deacetylases in cycling versus non-cycling cells, in light of the dynamics of histone acetylation patterns with a specific emphasis on heterochromatic regions of the genome.

本综述通过讨论HDACIs对周期和非周期细胞中组蛋白去乙酰化酶的抑制结果，来阐明组蛋白乙酰化模式的动力学特征，特别是对基因组异染色质的作用。

In eukaryotic cells, the fundamental unit of chromatin is nucleosome, which is composed of a histone octamer with two copies of H2A, H2B, H3 and H4 and 146 base pairs of DNA.

真核细胞中，核小体是染色质的基本单位，它由两个拷贝H2A、H2B、H3和H4所组成的核心组蛋白八聚体，及缠绕于其上的146bp DNA构成。

The over expression of p33^ING1b can promote the expression of p21^WAP1 which cooperates with p53 to restrain the cell growth by regulating the activity of the acetylating depended pathway.

ING1编码的蛋白通过组蛋白乙酰转移酶和组蛋白去乙酰化酶参与染色质的重塑，在DNA损伤修复方面发挥重要作用。

The Lab is interested in both genome storage, compaction and transcriptional regulation in eucaryotes, and more specifically in the structure, function, and molecular modification of chromatin.

该实验室主要研究真核细胞基因组的存储、压缩以及转录调？？，尤其是染色质的结构、功能核分子修饰等。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。