染色质

Since CBP can acetylate histone H3 and histone H4 and interact with Zta, we examined the possibility that CBP-Zta complex localizes on oriLyt and facilitates EBV genome replication upon viral reactivation by causing chromatin remodeling around oriLyt.

由於CBP可乙醯化组蛋白H3与组蛋白H4，且CBP可与Zta相互作用，因此我们探讨在EB病毒活化后，CBP是否会经由与Zta结合而座於oriLyt上，并改变oriLyt附近的染色质结构，进而有助於病毒DNA的复制。

Angiectasis, permeability were increased , inflammatory cell were transuded; The cardiac muscle injury conditions after hypoxia 4 h were similar with hypoxia 2h group, appeared lipid droplet, implied the oxidative metabolism of lipid got obstacle started from then; The cardiac muscle injuried conditions were got little improvement in hypoxia 6 and 8 hours team, mitochondria were increased and aggregatived, normal cell junction, sarcomere contract weaked; in hypoxia 10h group , mitochondria were increased and aggregatived obviously, a few glycogenosome were assembled, transverse tubule were expanded, all the changes may be the adaption of Gansu zokors in the hypoxia tolerance process to 4% hypoxia extent gradually.

在4%严重低氧耐受过程中，甘肃鼢鼠心肌超微结构在2h组出现血管扩张，通透性增加，有炎细胞渗出，异染色质边集；4h组心肌损伤状况与2h组接近，出现脂滴，提示脂类的氧化代谢在此时开始发生障碍，6和8h组心肌损伤状况逐渐好转，线粒体聚集增多，细胞连接正常，肌小节收缩较前有所减弱；10组线粒体增多聚集，线粒体脊增粗更为明显，少量糖原颗粒聚集，脂滴较前有所减少，横小管扩张增大变粗，出现了与能量代谢有关的结构适应性变化。

Tic division of F1 hybrid was normal ,anucleate cells and cells with micronuclei which were produced by asymmetrical separation of chromosomes were observed at the second meiotic division.

结果表明，杂种F1减数第一分裂基本正常，在减数第二分裂观察到由于染色体不对称分离产生的无染色质和仅带有微核的子细胞。

The light microscope observed four-layer structures of arthrodial cartilage, regularly ordered chondrocytes, even chromatin and clear nucleus in normal group. In the model group, the layer of arthrodial cartilage was thinning; chondrocytes in some regions showed karyopyknosis or necrosis with irregular order.

光镜下正常对照组关节软骨四层结构清晰可辨，软骨细胞排列整齐呈柱状，染色质分布均匀，细胞核清晰；模型对照组关节软骨层变薄，部分区域软骨细胞核固缩、坏死，软骨细胞排列紊乱，四层结构不易分辨。

Most endothelial cells fell off, elastic fibre autolyze; the number of SMC decreased, some SMC nucleus contracted completely or depressed, typical apoptosis body were seen in later stage, muscle silk autolyzed and disappeared mostly; in outer layer saw much collagenic fiber, arranged unorderly; inflammation cells were seen in the aneurysm wall(hypertrophy cell et al.).

多数瘤壁的内皮细胞溶解脱落，不连续，弹力纤维自溶；动脉瘤血管壁均可见SMC明显减少，较多SMC染色质边聚、固缩，部分SMC核全部固缩或出现不规则凹陷，SMC核胞浆或胞核部分出现脱落或裂解成碎片，晚期可见典型的凋亡小体出现，肌丝大都自溶消失：外膜可见大量的胶原纤维，排列较紊乱；瘤壁还可见炎性细胞浸润。

Cytology reveals cells with clear to lightly basophilic cytoplasm and round or indented nuclei with fine chromatin and indistinct nucleoli.

细胞学分析可见透明至浅染的酸性细胞质和圆形或缩进的细胞核含有正常的染色质和模糊的核仁。

Long stretches of the continuous DNA molecule wind around these clusters of proteins, or histones, forming beadlike complexes known

这些螺旋和超螺旋形成致密的染色体组结构。每个长链DNA与组蛋白和非组蛋白一起构成染色质物质。

Particular attention will bepaid in the field of gene expression regulation to high-throughput screening andidentification of cis-acting elements within the genome and to investigation ofinteraction manners of these regulatory sequences with regulatory proteins in theconditions of in vivo chromatin contexts.

如何在体内的染色质环境下，高通量、大规模地筛选与检测基因组内的顺式作用元件并研究其与反式作用因子间的相互作用，是当前和今后一个时期内基因表达调控领域内的研究重点之一。

The neoplastic epithelia are low cuboidal and not columnar in shape, with very large and atypical oval nuclei with vesicular chromatin and prominent nucleoli.

肿瘤性上皮呈低立方状而不是柱状，有很大的卵圆形核和显著核异型性，空泡状染色质和显著核仁。

Figure5 HE 10×10 The tumor cells are large and have rich cytolymph, red coloration. The nucleolus is round or elliptical shape.

图5 HE10×10 肿瘤细胞较大，胞浆丰富，红染，核圆或椭圆形，染色质细，核仁及核膜清楚，背景可见较多成熟淋巴细胞、嗜酸粒细胞，散在巨噬细胞。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。