染色体结合

The identified proteins are involved in a variety of cellular process including several zinc finger proteins relevant to transcription regulation, such as zinc finger 198, 263, 14, 224, zf6, novel protein similar to transcriptional represser CTCF, and kruppel-like zinc finger protein; two members of the ADAMs (a disintegrin and metalloprotease domain) family; two members of integrin family; several proteins involved in the signal transduction, cell-cycle control, chromatin remodeling and transcription repression; and also some proteins of cell skeleton and some with unknown functions.

鉴定出 的蛋白包括多个与转录调控相关的锌指蛋白，如锌指蛋白198、263、14、224、zf6、转录抑制因子cTcF样蛋白、幻肚pple样锌指蛋白等：两个含金属蛋白酶结构域和整合素结合结构域的家族成员ADAM28和ADAM17；两个整合素家族成员pZ整合素和含十个EGF样结构域的整合素；与细胞信号转导通路有关的蛋白；与细胞周期调控有关的蛋白；与染色体重塑和基因转录抑制有关的蛋白；细胞骨架蛋白以及其他功能未明的蛋白等。

In summary, the BRD7 gene acted as a candidate of tumor suppressor gene with NPC. The overexpression of BRD7 can partly reverse malignant phenotype of NPC cell line. The suppression effect of BRD7 on NPC tumorigenesis my be achieved by recognizing acetylated histone peptide through their motif-bromodomain, then modulating gene transcription by taking part in histone acetylating and chromosome remodeling, finally influencing signal-transduction pathways.

综上所述，BRD7基因作为一个重要的鼻咽癌抑瘤基因侯选者，在鼻咽癌细胞中的过表达后，可导致鼻咽癌细胞 HNE蛋白质表达谱发生改变，逆转其恶性表型，其作用机理可能是：BRD7基因通过其功能域彭聪硕士学位论文10Bromodomain与乙酚化的组蛋白特异性结合，参于染色体的乙酚化，染色质的组装，从而影响基因转录的调控，最终影响细胞内的信号传导通路并实现对细胞周期的调控，从而发挥抑制鼻咽癌细胞生长的作用。

To understand the listed contents:the studies about component of nuclear pore complex; the main functions of gp210;the different configuration models of sequence specific DNA-binding proteins; karyotype and chromosome bandings; configuration of chromatin and dene transcription; nuclear bodies is many subnuclear domains which have different conformation between chromatin.

了解核孔复合体成分的研究；gp210主要的功能；序列特异性DNA结合蛋白的不同结构模式；核型与染色体显带；染色质结构与基因转录；染色质之间的空间发现的许多形态上不同的亚核结构域——核体。

In order to develop a new path for gene mapping of fish, the digoxigenin and tritium labeled in situ hybridization techniques combined with multiple banding analysis on the pachytene bivalents of M. albus were studied using the wheat ribosomal RNA genes, pig growth hormone gene and MaSoxl (M. albus SRY boxl) DNA segment as the probes. Moreover, the techniques of random primed in situ DNA synthesis were also developed on the bivalents of M.

以两种异源基因和Ma Soxl为探针，采用地高辛或氟标记的原位杂交技术，结合点渍法和DNA印渍法分析，率先在黄鳝减数分裂二价体上开展基因定位研究，并与多重带带型分析相结合，以期为构建黄鳝染色体框架图奠定初步基础，为迅速改变鱼类基因定位研究的落后局面而开辟新的途径。

Methods A method combining pulsed field gel electrophoresis with low-frequency-cleavage restriction endonucleases was established to analysis DNA of Enterobacter cloacae.

方法利用脉冲场凝胶电泳结合低频限制性内切酶技术对阴沟肠杆菌染色体DNA进行分析。

The results indicate that at least 28 fissions, 49 fusions and 4 inversions were needed to"convert" the dog karyotype to that of the red panda, suggesting that extensive chromosome rearrangements differentiate the karyotypr of red panda and dog.

结合已发表的狗与家猫的比较染色体图谱，我们推测：小熊猫与家猫之间共存在26个同源片段，二者的核型之间显示了较高的同源性。

Polytene chromosome structure is a characteristic of some polyploid cells where several to thousands of chromatids are closely associated with perfect alignment of homologous DNA sequences.

多染色体结构是多倍体细胞的特征。在多倍体细胞中，有几个至几千个染色单体与相对应的DNA序列精确结合。

After doing that, the new generation was selected by synthesizing roulette wheel and optimization selecting.

再结合旋转轮盘赌和最优化选择新一代染色体。

The objective of this thesis was to isolate, characterize and physically map the novel genes on pig chromosome 12 using information derived from comparative mapping and pig EST database. The association between genes and some economic traits is also studied.

本论文根据比较基因定位信息，并结合公共数据库中的EST资源，分离、定位猪12号染色体上的新基因，并对基因与部分性状进行了初步关联分析，取得了如下结果： 1。

ABSTRACT The objective of this thesis was to isolate, characterize and physically map the novel genes on pig chromosome 12 using information derived from comparative mapping and pig EST database. The association between genes and some economic traits is also studied.

本论文根据比较基因定位信息，并结合公共数据库中的EST资源，分离、定位猪12号染色体上的新基因，并对基因与部分性状进行了初步关联分析，取得了。。。

She gently rebuff ed him, but agreed that they could be friends

她婉言拒绝了，但同意作为朋友相处。

If in the penal farm, you were sure to be criticized.

要是在劳改农场，你等着挨绳子吧！