染色体基因

For example one could be an allele for Black coat and one for Gold coat.

（在1个染色体上的两个基因）它可以一个黑色基因另一个是金色基因。

Nigra, B. oleracea and B. carinata belonged to class 2A according to the classification of karyotypes by Stebbins (1971). According to Levitzky's and Stebbin's view, the more asymmetric karyotype a species has, the more evolved it is. Therefore, B. campestris is the furthest evolved species among the elementary species, and B. juncea and B. napus the furthest among the amphidiploid species. Compared with the previous reports, there is no any cytoplasm in the chromosome sample prepared using this protocol which is very useful for the karyotype analysis, as well as the FISH research on Brassica species.

对上述研究结果分析表明：（1）芸薹属复合种是由基本种相互杂交而成；（2）B基因组与A或与C基因组亲缘关系较远，而A和C基因组亲缘关系较近；（3）芸薹属复合种在演化过程中，发生了染色体结构上的重排现象；（4）芸薹属复合种演化过程中，rRNA基因位点发生了减少；所获结果与国外同类报道相比表明：国内的白菜型油菜存在新的rRNA基因位点，即rRNA基因在芸薹属同一物种不同的品种间具有多态性；有关这类研究国内尚未见报道。

The results showed that the hereditary mode of handedness or preferential foot or hand-clasping is the dominant heredity of single gene of autosome,and the right type of all of them is the dominant character.

采用Slater区分单基因和多基因遗传的计算模式及Smith无偏分析方法对21个家系资料的分析表明：利手、优势足、扣手特征均为常染色体单基因显性遗传，R型为显性性状。

The Chinese annotations includes gene names, chromosome map, cellular component, molecular function, biological process, and morbids.

2006年8月，《人类基因功能手册》，约120万字，收录人类基因3.9万个，中文注解包括基因名称、染色体定位、细胞定位、分子活性、参与过程、表型病变等。

Markers Xgwm257 and Xgwm319 were resistant codominant, while marker Xgwm296 was resistant dominant. All three markers related to resistance are Ae.

由于该基因不同于定位在小麦2B染色体上的已知抗白粉病基因Pm6和Pm26，应该是一个新的抗病基因，暂定名为PmPS5B，建议定名为Pm32。

The transforming growth factor-β superfamily, a large group of highly conserved growth factors including TGF-βs, activins and BMPs, regulate a wide variety of cellular functions such as proliferation, differentiation, apoptosis and migration. Signals from these growth factors are transduced by a group of Smad proteins. To date, there are nine vertebrate Smads, including the receptor-activated Smads , Smadsl-3, 5 and 8, the common mediator Smad4 and Smad4β, and the inhibitory Smads, Smad6 and 7. Signaling is initiated when the ligand induces assembly of a heteromeric complex of type Ⅱ and type Ⅰ TGFβ receptors. Then R-Smads are directly phosphorylated by activated type I TGF-β receptors.

在多种SMADS中，SMAD5令我们产生兴趣，基于三个原因：1、Smad5基因敲除胚胎中发现卵黄囊的异位造血以及CFU-GM祖细胞数目增加，表明SMAD5可能是早期造血发育的负向调控基因。；2、应用反义核酸封闭Smad5可以逆转TGF-β对祖细胞增殖的抑制效应，表明它可能介导TGF-β信号转导，后者的异常，包括某些SMADS的功能异常，和白血病紧密相关；3、Smad5基因定位在人染色体5q21，此区域的缺失和急性髓系白血病和骨髓增生异常综合症相关，因此，Smad5被怀疑为白血病抑制基因。

Our research utilized two cell lines carrying a bisatellite microchromosome originated from two normal phenotypic families found by Professor Jiahui Xia to make the BM become a new vector for gene therapy. The research will finally establish a novel vector that can be steadily transmitted, has enough capacity to carry foreign genes, has no harm to human being, has no immunogenecity and is easy to transfer. This research can provide brand new vector tool for gene therapy of human hereditary diseases and tumors.

本研究利用夏家辉教授发现的2个带有双随体小染色体而表型正常的家系所建立的细胞株作为研究材料，用BM作为基因治疗新载体，以求最终建立一种能稳定遗传、携带外源基因容量足够大、对人体无害、无免疫原性和易于基因转移的新型载体，为人类遗传病和肿瘤的基因治疗提供崭新的载体工具。

The result indicates that there are one dominant and one recessive complementary gene that are effective against the Indian race 2E16. However, the monosomic analysis results indicated there was one resistant gene to the Indian race 2E16 and the gene was located on chromosome 3B. The current study shows that it is different from the known genes.

采用常规杂交分析方法，对铭贤169与阿夫杂交的F_1、F_2、BC_1代及其亲本进行抗性鉴定和统计分析，结果表明，阿夫对2E16菌系的抗性至少由1对显性抗条锈基因控制；通过单体分析将阿夫抗2E16菌系的1对显性基因定位在3B染色体上，等位性分析表明该基因不同于目前的已知基因。

Regulator gene A gene whose product can promotor or prevent the TRANSCRIPTION of structural genes, which may or may not be adjacent to other regulator genes, and may even be on another chromosome.

调节基因：这种基因的产物可以促进或抑制结构基因的转录，其可能与其他的调节基因相连，也可以不相连，甚至两者可以不在同一染色体上。

In summary, the BRD7 gene acted as a candidate of tumor suppressor gene with NPC. The overexpression of BRD7 can partly reverse malignant phenotype of NPC cell line. The suppression effect of BRD7 on NPC tumorigenesis my be achieved by recognizing acetylated histone peptide through their motif-bromodomain, then modulating gene transcription by taking part in histone acetylating and chromosome remodeling, finally influencing signal-transduction pathways.

综上所述，BRD7基因作为一个重要的鼻咽癌抑瘤基因侯选者，在鼻咽癌细胞中的过表达后，可导致鼻咽癌细胞 HNE蛋白质表达谱发生改变，逆转其恶性表型，其作用机理可能是：BRD7基因通过其功能域彭聪硕士学位论文10Bromodomain与乙酚化的组蛋白特异性结合，参于染色体的乙酚化，染色质的组装，从而影响基因转录的调控，最终影响细胞内的信号传导通路并实现对细胞周期的调控，从而发挥抑制鼻咽癌细胞生长的作用。

In the United States, chronic alcoholism and hepatitis C are the most common ones.

在美国，慢性酒精中毒，肝炎是最常见的。

If you have any questions, you can contact me anytime.

如果有任何问题，你可以随时联系我。