染色体基因

Recently,many articles reported the close correlation between human height and gene polymor- phism,such as GH1 gene, VDR gene ,CYP19 gene,estrogen receptor gene and a few regions in the Y chromo- some.

GH1基因、 VDR基因、CYP19基因、雌激素受体基因以及Y染色体均与人的身材高矮有密切联系。

As to Balilla erect panicle type,(the same subject for the following 11-16), the curvature of panicle neck had a very significantly positive correlation with panicle length, neck panicle length, neck panicle internode length, the secondary internode length, leaf length and leaf sheath length, and had an opposite correlation with leaf width and density of seed setting.

来自吉林的直立穗型品系Z1和来自黑龙江的直立穗型品种龙交91060—2与巴利拉型直立穗型品种的直立穗其因分属于3个不同的位点，各自位于3对同源染色体上，彼此遵循基因的自由重组和独立分配规律。Z1由1对显性主效核基因控制，龙交91061—2由1对隐性主效核基因控制。3个直立穗型基因位点可能具有累加效应，直立穗型效应位点越多，则颈穗弯曲度越小，穗的直立性越强。

Lines which were 2n=21"+1" and one line which was 2n=20"+2", one line which was 2n=43. The salt-resistance addition line Line15 was confirmed as a Disomic alien addition line by C-banding, SSR, FISH methods, and the two alien addition chromosomes had close correlation with the long arm of the second homoeologous group, the centromere region of the third homoeologous group and the short arm of the seventh homoeologous group. We also confirmed the particular C-banding type of the alien addition chromosomes by C-banding following FISH method. The drought-resistance addition line Line17 was found also as a Disomic alien addition line by SSR and FISH detection. The alien addition chromosomes had close correlation with the short arm of the second homoeologous group.

对导入赖草优质耐盐基因的株系Line15进行了C-分带、荧光原位杂交、SSR相结合的鉴定，确认Line15是一个二体异附加系，附加的一对染色体与小麦的第二同源群长臂、第三同源群着丝粒和第七同源群短臂密切相关，并确定了Line15的外源染色体C-分带特征带型，为目后鉴定Line15附加系的真伪提供了简便快捷的途径；对抗旱附加系Line17进行了荧光原位杂交和SSR检测，得出Line17也是一个二体异附加系，外源染色体与小麦的第四同源群短臂密切相关。

It has been thought that the complicated gene-gene interaction, heterogeneity of clinical presentation and numerous farraginous experimental data make it more difficult to draw a firm conclusion with genetic research work.

这主要是因为精神分裂症临床分型复杂，症状多样，若将不同类型的患者混杂起来研究将难以对这种异质性疾病作出可信的结论；同时该病作为多基因病的一种，其发病是由许多微效基因共同作用决定的，若孤立地研究某个候选基因或候选染色体区域与疾病的关系，也难以得出满意的结果；而且在研究结果的分析中，某个基因对发病的微小贡献将被&淹没&在巨大的数据信息中，难以提取。

Both single genes and chromosome segments may be hemizygous; for example, the X chromosome in the heterogametic sex, and whole chromosomes in aneuploids.

单独的基因和染色体片断都有可能是半合子。例如在异型性别中的 X 染色体以及非整倍体中的全部染色体。

The results showed that all of them could detect the presence of ZFY DNA sequences except a 46 XX"male"and a 46 XX hermaphrodite, our findings confirmed that Ferguson-Smith〔1966〕 forwarded the hypothesis that the X-Y intercharge model for XX maleness can be regarded as an abnormal exchange initaited in a region proximal to TDF and extending to the telomere,and,also strongly suggested that ZFY gene palyed an important role in sex determining of human.

结果除一例46XX两性畸形，一例46XX&男性&外，余均能检测到ZFY DNA序列(ZFY DNA序列存在于46XX真两性畸形和45XO Turner's综合症，在国内外尚未见报道)。证实了1966年，Ferguson-Smith提出的理论：在父源减数分裂期间，X-Y发生不等交换，导致Y染色体DNA插入性易位。XX男性是由于Y染色体上的TDF基因转移至X染色体上所致。

The main results and conclusions are as followings.1, The histone deacetylase inhibitors were used to feed the larve of the fly, and then the polytene chromosomes were observed under the microscope.

得到的主要结果和结论如下： 1，通过用去乙酰化酶抑制剂处理果蝇幼虫，观察果蝇多线染色体在热休克基因处的形态变化，发现去乙酰化酶抑制剂介导的乙酰化水平的升高可引起染色体结构的显著变化，推测乙酰化修饰不仅影响分子间的相互作用而且还可以影响染色体的高级结构。

Therefore, we selected the 5 genes, as well as SMTN gene related to human cardiovascular diseases, for chromosomal mapping, CDS cloning and analysis, spatio-temporal distribution, mutation riddling, and association analysis with production traits of 3 porcine populations. We expect to know the structure and function of these 6 genes primarily, and supply data for porcine marker assistant selection of improving meat production.

因此，本研究选择NADH呼吸链相关基因，以及与人类心血管疾病相关的SMTN基因，以猪的骨骼肌为研究对象，用人×仓鼠体细胞杂种克隆板进行6个基因的染色体定位、CDS克隆和序列分析、用半定量RT-PCR进行时空表达谱分析、进行突变位点的筛选、并利用3个猪群的产肉性状资料进行基因型与性状的关联分析，以期初步了解这些基因的结构和功能，并为改进猪产肉性能的标记辅助选择提供资料。

Ninety-three patients with forty-two azoospermia and fifty-one severe oligozoospermia were recruited in present study. Y chromosome microdeletions were screened by detection of four locus SY84, SY134, SY255 and SPGY1 gene spaning the AZFa, AZFb and AZFc subregions of Y chromosome. The total incidence of Y microdeletions was 16%( 15/93 )in present study. Eight men in 42 patients with azoospermia had Y microdeletions, of whom 6 were AZFc deletion and 2 were AZFb deletion.

通过对93例男性不育（42例无精症和引例严重少精症）患者，Y染色体 SPGY基因、AZFa－SY84、AZFb－SY134和 AZFc－SY255位点缺失情况的研究，我们发现男性不育患者 Y染色体微缺失的发生率为 16％（ 5旧3人 42例无精子症患者中，有8例存在Y染色体微缺失，其中6例为AZF。

Multiple genetic changes have been found in ESCC,but little is known about major oncogenes and tumor suppressor genes involved in this disease.To surveying chromosome imbalances in this disease,we analyzed statistically high-frequency chromosomal changes of ESCC from the previous studies by multicolour fluorescence in situ hybridization and comparative genomic hybridization.

为鉴定与食管癌关系密切的基因，本研究从染色体畸变的角度出发，在实验室前期工作及相关文献的基础上，统计分析食管癌染色体畸变谱，发现3、5、8号染色体重排及着丝粒断裂再重组可能是最常见的结构改变，3q、8q增益是最常见的数目异常。

In the United States, chronic alcoholism and hepatitis C are the most common ones.

在美国，慢性酒精中毒，肝炎是最常见的。

If you have any questions, you can contact me anytime.

如果有任何问题，你可以随时联系我。