染色体基因

Objective: To explore the relationship between the genetic instability of microsatellite and the evolution of chronic myelogenous leukemia.

研究表明，许多肿瘤的发生和发展与微卫星DNAs的遗传不稳定性即基因组微卫星的不稳定性和染色体等位基因微卫星序列的杂合性缺失有关［1］。

Niemann-Pick disease type C is a fatal, neurovisceral storage disease neuropathologically characterized by cytoplasmic sequestration of cholesterol in neurons and progressively widespread neuronal loss, caused by mutations in genes NPC1 and NPC2 (also HE1) which encode for proteins required for the intracellular trafficking of cholesterol from lysosomes to late endosomes.

C型Nimann-Pick病是一种致命性的神经内脏脂质沉积病，其主要病理特征为广泛、进行性的神经元脱失，它由分别位于18号和14号染色体上编码与细胞内转运胆固醇有关蛋白质的NPC1和NPC2基因突变所致。

Recently, the gene responsible for nevoid basal cell carcinoma syndrome, an autosomal dominant disorder characterized by multiple malformations and susceptibility to a variety of tumors and, particularly, to BCC, has recently been identified as PTCH.

痣样基底细胞癌症候群是一种体染色体显性遗传疾病，其主要表现有基底细胞癌、成齿的角质囊肿和其他多种骨骼发育异常，这个疾病被认为和PTCH基因突变有关。

It was observed that although the pSym-curred strain HND29SR could not nodulate on the host plant Heinong 33, there was no difference in the root colonization dynamics and density of rhizobium population between HND29SR and its wild-type HN01 or reference strain HN01L in sterilized pot-sand system.

这一现象说明HN01所含共生大质粒不影响其根圈定殖行为，有理由推测影响HN01根圈定殖行为的有关基因可能存在于染色体上或另外两个内源质粒上。

Chromosomal abnormality and DAZ gene deletion are closely related to the spermatogenesis impediment, and they are important reasons for azoospermia and oligospermia.

染色体异常和DAZ基因缺失与生精障碍密切相关，是无精、少精的重要原因。

Infertility ; male ; Oligospermia ; Gene deletion ; Y chromosome ; Polymerase chain reaction

不育；男性；少精子症；基因缺失； Y染色体；聚合酶链反应

RFLP genetic linkage map of wheat recombinant inbred lines derived from W7984 Opata,was used to study QTL of 33 traits associated with water use efficiency.Compared with QTL map of 7 group homeologues chromosomes,the results were showed as follows:nearby the centromeric region of 1A and 1B chromosome,the gene cluster of controlling photosynthetic and root traits were located.

我们利用W7984 Opata重组近交系的RFLP作图群体，对33个与小麦水分利用效率有关的性状进行了QTL遗传图谱比较分析，结果显明：在第一部分同源群染色体（1A，1B）上的着丝粒周围，分布有控制光合作用和根系特性的基因簇。

MC4R gene mutation seems to be an important cause of obesity in Chinese papulation.

人MC4R基因位于染色体18q22，仅一个外显子，编码332个氨基酸的蛋白质。

Multiple familial trichoepithelioma is a benign skin tumor related to the pilosebaceous apparatus and inherited in autosomal dominant manner. Attentions have been focused on the mapping and mutation of the disease gene. But the clinical features of MFT are not clearly analyzed in Chinese.

多发性家族性毛发上皮瘤是一种皮肤附属器的良性肿瘤，是常染色体显性遗传性疾病，目前的研究集中在其致病基因的定位及突变上，但对该病的临床分析不够透彻。

Two major genes controllinggrain hardness,Pina and Pinb, was located at the short arm of chromosome 5DS.

控制硬度的主效基因Pina 和Pinb 位于染色体5D 短臂上，软质对硬质为显性。

She gently rebuff ed him, but agreed that they could be friends

她婉言拒绝了，但同意作为朋友相处。

If in the penal farm, you were sure to be criticized.

要是在劳改农场，你等着挨绳子吧！