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染色体基因

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Objective To explore the effect of chromosomal abnormality and polygenic inheritance factor in female children with short stature.

目的探讨染色体异常和身高的多基因遗传因素在身材矮小女童中对矮小身材产生的作用。

To search the genetic heterogeneity of ADPKD and to compare the clinical presentation between ADPKD type 1 and 2 in Shanghai Han population, develop a method of gene diagnosis by linkage analysis with microsatellite DNA tightly linked to PKD1 and PKD2 and make gene diagnosis of mutation carriers before cystogenesis, detect single nucleotide polymorphism of PKD2 and its frequence in Han population.

根据知情同意的原则,选取80名无亲缘关系的上海市汉族健康志愿者进行与PKD1和PKD2连锁的微卫星DNA多态性的研究,选取43个常染色体显性多囊肾病家系进行遗传异质性、表型差异研究及基因诊断。

Objective:To explore the cytogenetic change after hematopoietic stem cell transplantation in patients with leukemia.

目的:探讨造血干细胞移植后白血病细胞染色体核型和基因表达观察的意义。

The results of genetic diagnosis were identical to cytogenetic analysis which cost more than two weeks to complete.

将基因诊断结果与染色体核型分析结果对比,二者完全一致。

It is concluded that the value of routine cytogenetical and molecular biological analysis in diagnosis for potential CML cases,which mimicked ET as in this presentation,is very distinctive,and the importance is magnified by the recent availability of imatinib,a specific inhibitor of the bcr/abl tyrosine kinase produced by the Philadelphia chromosome.Every case of

对血小板明显增多的患者应及时进行Ph染色体及bcr/abl融合基因表达水平的检测,这对于ET及CML的诊断和鉴别诊断极为重要,以避免误诊、误治。

Its twenty-six biochemical marker genes distributed over tweleve chromosomes are not all dentical to other inbred strains,Its H-2 genes are H-2Kd,H-2Dk.genotype of coat color is AABBccDD,Its differential functi...

所检的分布在12条染色体上的26个生化标志基因未见与其它近交系小鼠完全相同。H-2位点基因为H-2Kd、H-2Dk。

In additional, eIF5a2 is located on chromosome 2B using Langdon D-genomic disomic substitution lines and the expression of eIF5A was also investigated by Semi-quantitative PCR.

进一步研究表明eIF5a2位于2B染色体上,并用半定量RT-PCR 研究了小麦eIF5A基因的表达情况。

In particular, the documentation of rapid and extensive non-Mendelian genetic and epigenetic changes that often accompany nascent polyploidy is revealing: the resulting non-additive and novel gene expression at global, regional and local levels, and timely restoration of meiotic chromosomal behavior towards bivalent pairing and disomic inheritance may ensure rapid establishment and stabilization as well as its long-term evolutionary success.

特别是,所发现的在多倍体形成初期,快速且大量产生的非孟德尔遗传变异和表观遗传变异为相关机理的探讨提供了重要的启示。不同尺度上的基因非加性表达以及染色体二价体联会和二体遗传方式的快速建立可能对新形成多倍体的早期稳定和长期进化优势都具有重要意义。

Ten transformants and 10 conjugons showed high-level resistance against aminoglycoside antibiotics,all of which the value of MIC>256μg/mL carried armA gene.Conclusions:The Ab clinical isolates from burn ward in Gansu Province People\'s hospital have high drug-resistance.16S rRNA methylases gene exsist in Ab and locate in plasmid chromosome.They are easily disseminative,which demonstrated a very high level of resistance to various aminoglycosides.

甘肃省人民医院烧伤病房鲍氏不动杆菌临床分离株有非常高的耐药率,16S rRNA甲基化酶基因armA在鲍氏不动杆菌中存在,且位于质粒染色体上,易于传播和扩散,导致所有氨基糖苷类抗菌药物高水平耐药。

In this experiment, 7 microsatellite DNA loci linked with PPAR gene were selected from the published genetic map of chromosome 13 in pig, and polymorphisms of these microsatellites in 100 samples from Sutai pigs (Duroc × Erhualian) populations were detected.

从已公布的猪 13 号染色体连锁图谱中选择与PPAR 基因连锁的 7 个微卫星座位,在苏太猪群体中对这些位点进行群体遗传学特性分析。

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