染色体基因

The majority of the loci are at the autosome and five loci at the Z chromosome.Four loci have multiple allelic series.

这些基因座多数位于常染色体上，有5 个基因座位于Z染色体上，有4 个基因座存在有复等位基因系列。

Human β E globin gene can be detected in different position of different chromosomes in tr...

FISH能直观地反映外源基因在转基因动物染色体上的整合状态，该方法可对转基因动物及基因转移研究中的外源基因整合后进行染色体定位检测。

They are often morphologically distinct from A chromosomes, being smallerand more highly heterochromatic in most cases. B chromosomes do not pair with Achromosomes, and they are inherited in a non-Mendelian way, exhibiting meiotic andmitotic instability and nondisjunction. However, B chromosome DNA is quiteidentical to the corresponding sequence on the A chromosome complement. So far afew B chromosome specific DNA sequence have been identified. Specific DNAsequences on B chromosome have been the attractive research area on Bchromosomes.

现已在千余种植物和近三百种动物中被发现。B染色体与物种中正常染色体不同：独立于整倍体基因组之外，减数分裂时不与A染色体发生联会和配对，细胞分裂后期不分离，非孟德尔遗传，富含异染色质，不含对宿主主要性状有影响的基因等。B染色体DNA的分子组成既与A染色体极为相似，具有A染色体DNA分子组成的一般特征：富含重复序列和转座成分，染色体三大功能组件DNA高度同源；又与之相区别，含有B染色体特异的DNA序列，这些DNA序列可以为探讨B染色体的起源和进化提供有价值的信息。

Here we show that a newly evolved sex chromosome contains genes that contribute to speciation in threespine stickleback fish.

基因定位研究显示，新形成的X染色体包含雄性求偶行为基因，而先祖X染色体既包含行为隔离基因，又包含杂交种雄性不育基因。

Because man can only inherit genes carried on the sex chromosomes while woman have 2 sex chromosomes, even if one of sex chromosome has defect, there is another one can take place for.

这是因为男人只能继承母亲身上一个X染色体的基因。而女人有2个X染色体，即使一个辨色基因出现缺陷，还有另一个基因可以顶替它的位置。

CML is cytogenetically marked by the philadelphia chromosome, which originates from a reciprocal translocation between chromosome 9 and 22 and is molecularly marked a chimeric bcr-abl gene, resulting from juxta-positive of the abl proto-oncogene on chromosome 9 with the bcr gene, which is normally located on chromosome 22. The chimeric bcr-abl gene expression an 8. 5kb hybrid mRNA transcript giving rise to a 210-KD fusion protein (P210〓) with increased tyrosine kinase activity. P210〓 plays a key role in the pathogenesis of CML. The continuous cell line K562 was established from the pleural effusion of a 53-year-old female with CML in terminal blast crisis, and was a human erythroleukemia line, contained Ph chromosome.

绝大多数慢粒患者白血病细胞中具有Ph染色体，是由9号染色体长臂3区4带和22号染色体长臂1区1带相互易位形成，即t（9；22），使位于9q〓的c-abl原癌基因在第二外显子的5'端断裂并易位到22 q〓的M-bcr基因第2或第3外显子的3'端，形成异常的bcr-abl嵌合基因，该基因转导出异常的mRNA，编码并翻译出P210蛋白，该蛋白具有很强的酪氨酸激酶活性，使粒细胞发生恶性增殖。K562细胞属于慢粒急变、红白血病细胞株，具有Ph染色体。

There are 11 gene bindings disappear in the normal group, but appear in the model group, and then disappear in the treat group, that indicates the 11 gene bindings are correlated with the epilepsy and Caohuozhimutang. After searching in the Gene Bank, 7 bindings in the 11 gene bindings are homogenic with the 8q31 ribosomal protein gene, 15p12 paraneoplastic neuronal antigen gene, 4q22 diacylglycerol kinase iota gene, xq37 FMR2 protein and 11p11 roudabout homolog 1, and 4 bindings of which are novel gene.

经NCBI美国国家基因库检索，这11条基因中的7条已知基因分别与位于鼠染色体8q31位置的核糖体蛋白、15p12位置的周围肿瘤神经元的抗原(paraneoplastic neuronal antigen)、4p22位置的甘油二酯酶、xq37位置的FMR2蛋白（FMR2 protein）的基因以及以及位于果蝇染色体11p11位置的交叉同族体（roundabout homolog 1）有极高的同源性；有4条基因片段同源性较低，为功能未知的新基因，已经在GeneBank进行了注册，注册号分别CK325391、CK325392、CK325393、CK325394。

It is caused by mutations in dyskerin-encoding genes, telomerase-encoding RNA component genes and reverse transcriptase genes, as well as other uncharacterized genes. There are three inherited forms, including X-linked, autosomal dominant and autosomal recessive inheritance.

先天性角化不良是与编码角化不良蛋白基因、编码端粒酶的RNA组份基因、编码端粒酶的逆转录酶基因突变及其他未确认的致病基因突变引起的基因病，其遗传方式有：X-性联隐性遗传、常染色体显性遗传及常染色体隐性遗传。

The crossover operation in the traditional GA operating is that choose two chromosome cross only at random also you can cross a bit, match and cross partly, cross order and cross cycle etc.

传统GA算法中的交叉操作，是随机选取两个染色体进行单点交叉(也可以多点交叉、部分匹配交叉、顺序交叉和周期交叉等等)，但是不管是采用何种交叉操作，新的子代染色体某一基因位上的值都是由两个父代染色体中相应基因位值经过一定交叉运算(直接交换或经算术运算等)所得到的，采用这种交叉算子操作使群体经过多次迭代后群体中的个体开始出现极大的相似性，因此照此下去就会出现早期收敛现象，使得算法的收敛速度非常慢甚至只能求到问题的局部最优解。

The crossover operation in the traditional GA operating is that choose two chromosome cross only at random also you can cross a bit, match and cross partly, cross order and cross cycle etc.

传统GA算法中的交*操作，是随机选取两个染色体进行单点交*(也可以多点交*、部分匹配交*、顺序交*和周期交*等等)，但是不管是采用何种交*操作，新的子代染色体某一基因位上的值都是由两个父代染色体中相应基因位值经过一定交*运算(直接交换或经算术运算等)所得到的，采用这种交*算子操作使群体经过多次迭代后群体中的个体开始出现极大的相似性，因此照此下去就会出现早期收敛现象，使得算法的收敛速度非常慢甚至只能求到问题的局部最优解。

In the United States, chronic alcoholism and hepatitis C are the most common ones.

在美国，慢性酒精中毒，肝炎是最常见的。

If you have any questions, you can contact me anytime.

如果有任何问题，你可以随时联系我。