染色体基因

Results: miR27a was identified as the most stable reference gene by geNorm and Normfinder software. Among the 52 microRNAs detected by real time PCR array, miR-33 and miR-19a were significantly down-regulated, whereas miR-130 were significantly up-regulated in the hippocampus of Ts65 Dn mice as compared with the euploid control mice. The expression of miR-802, which was the trisomy chromosome 16 derived microRNAs, was very low in hippocampus with no difference between the two groups.

结果：geNorm和Normfinder两种方法均选定miR-27a为最稳定的内参照基因，共检测了52种microRNAs，其中miR-33和miR-19a在Ts65Dn小鼠海马组织中表达显著下调，miR-130在Ts65Dn小鼠海马组织中表达显著上调，小鼠16号染色体三体区段包含的miR-802在Ts65Dn小鼠和对照二倍体小鼠海马组织中表达量均低，差异没有统计学意义。

The stable expression of exogenous gene in E.coli chromosome had no effect on the bacterial growth and propagation.

外源基因在大肠杆菌染色体上的稳定表达并不影响细菌的生长繁殖。

Only using sperm that carry an X chromosome to fertilise the egg means only unaffected girls are conceived.

只选择带有X染色体的基因的精子进入卵子。也就是说生一个没有缺陷的女儿。

Since Fisher's time, it has been realized that genes can sometimes influence the chromosome or gamete in which they find themselves so that the gamete will be more likely to participate in fertilization .

自菲希尔的时代以来，科学家们已意识到，基因有时能影响到它们所存在于其中的染色体或配子，因此，配子将更有可能参与到授精过程中来。

Genes important for male gametogenesis involved in highly con-served landmark events such as meiotic recombination, formation of the synaptonemal complex, sister chromatid cohesion, spermiogenesis during postmeiotic stages, and checkpoints and factors required for the meiotic cell cycle .

精子发生中的重要基因与一系列精子发生过程中阶段性的细胞事件密切相关，例如减数分裂重组、联会丝复合物的形成、姊妹染色体的结合、减数分裂后精子的变态以及减数分裂周期中的关键点和必需因子等。

THE CORRELATION BETWEEN POLYMORPHISM OF ALDOSE REDUCTASE GENE AND DIABETIC NEPHROPATHYCHEN WEN HUADepartment of Geratology, The Affiliated Hospital of Yanbian University, Yanji 133000, China

摘要］ ①目的探讨染色体7q35区醛糖还原酶基因启动子区C 106T多态性与2型糖尿病肾病相关性。

Human X chromosome shrot arm Xp11.3~p21.3 is an area, where several genetic disease gne loci are located.

人类 X染色体短臂11.3-21.3区是含有视网膜色素变性等数种遗传病基因位点的区域。

These variants change the conformation and stability of nucleosome to facilitate transcriptional activation or deactivation, DNA repairing, heterochromatin formation, and others.

这些变体通过改变核小体的空间构象和稳定性，决定基因转录的激活或沉默，DNA的修复，染色体的异染色化等。

Loss of heterozygosity on 6q is common changes in primary lung cancer.

结论6号染色体长臂的杂合性缺失在原发性肺癌中是常见的染色体改变，并且在丢失的位点附近有一种或几种肿瘤抑制基因与人类原发性肺癌的发生与发展相关联。

Objective To investigate the relationship between loss of heterozygosity of the allele genes on 3p and the pathogenesis of NSCLC.

目的 探讨非小细胞肺癌中第3号染色体短臂(3p)上两个独特区域——3p14和3p25等位基因的杂合性丢失与NSCLC发生、发展之间的关系。

She gently rebuff ed him, but agreed that they could be friends

她婉言拒绝了，但同意作为朋友相处。

If in the penal farm, you were sure to be criticized.

要是在劳改农场，你等着挨绳子吧！