染色体基因

Truncation mutations in the adenomatous polyposis coli protein are responsible for familial and sporadic colonic tumours. Except for its function as a role in regulating b-catenin, recent studies show that APC has additional roles in cytoskeletal regulation. It binds to microactin and microtubules directly and indirectly. Furthermore, APC plays an important role in mediating the detraction of chromosome.

编码APC蛋白(adenomatous polyposis coli， APC)基因的缺失突变会导致家族性和散发性的结肠癌，APC蛋白除了能直接参与Wnt信号途径调节b-catenin的浓度之外，最近的研究表明APC蛋白能够与细胞骨架的主要成分微管和微丝直接或间接结合，通过调节微管的解聚和聚合，间接调节染色体的分离，作为潜在的细胞骨架调节分子将细胞骨架与重要的细胞信号转导通路紧密联系在一起。

All 17 genotyped CHMs demonstrated androgenetic diploidy, including the CHM with retained p57 expression; this case also demonstrated trisomy of chromosome 11, accounting for the aberrant p57 expression.

所有17例基因确诊的CHMs都显示父系二倍体，包括那例表达p57的CHM，这例同时也显示了三倍染色体11，这也解释了p57为何异常表达。

This result suggests that genes are not disjointed entities with parts spread out from one end of a chromosome to another.

这个结果表明，基因并非独立存在的，分散于染色体一端到另一端各个部分的个体。

Homology search of genomic DNA can reveal pseudogene sequences, and some properties of pseudogenes such as population, distribution, and homology family can be examined.

通过序列同源性搜索，可以收集基因组中假基因的群体特性、染色体分布和同源家族等特性。

According to the results this paper also analyzed genes distribution rule in chromosomes.

在此基础上探讨了这些基因在染色体上的分布趋势。

Together, these data suggest that in Drosophila, presence of H3.3K4me in the chromatin of active genes is dispensable

这些数据表明，在果蝇、存在的H3.3K4me活跃的基因在染色体则可有可无的成功，只有在大多数细胞转录起着至关重要的作用，在生殖器官。

Dpy-17 is a gene on chromosome III; mutations in it cause animals to be dumpy.

。 dpy-17是3号染色体上的一个基因，它突变会导致动物变得粗胖。

The types of histone methyltransferases, the relationship between methylation of Lysine 9 of H3 and the formation of heterochromatin, gene regulation in euchromatin, and that with DNA methylation, were mainly introduced.

主要阐述了组蛋白甲基转移酶的类型，组蛋白H3中第9位赖氨酸甲基化与异染色质的形成、常染色体中基因表达的调控，以及与DNA甲基化之间的关系，说明了组蛋白甲基化与组蛋白乙酰化、磷酸化的相互关系，指出组蛋白甲基化对维持细胞各种状态的平衡起到极其重要的作用。

HCN4 is as wrong as all sorts of rhythm of the heart the relationship is close, familial sex Dou Xingxin has eaten the transmissibility rhythm of the heart such as delay show outside gene of wrong patient HCN4 child alkaline base be short of break or the change that bump changes mutation to bring about HCN4 passageway albumen, cause If extent to decrease, belong to euchromosome dominance heredity.

HCN4和各种心律失常关系密切，家族性窦性心动过缓等遗传性心律失常患者HCN4基因外显子碱基的缺失或颠换突变导致HCN4通道蛋白的改变，引起If幅度减少，属于常染色体显性遗传。

An organism having a euploid chromosome number.

位点是基因在染色体的位置。

She gently rebuff ed him, but agreed that they could be friends

她婉言拒绝了，但同意作为朋友相处。

If in the penal farm, you were sure to be criticized.

要是在劳改农场，你等着挨绳子吧！