杂合的

Objective Loss of heterozygosity of tumor suppressor gene is believed to play a key role in carcinogenesis of colorectal cancer.

目的抑癌基因的杂合缺失被认为是结直肠癌形成的通路之一，本实验拟通过对染色体10q23～24区的LOH分析，发现高频杂合缺失区域并筛查与结直肠癌相关的抑癌基因。

The heterozygote genotypes in F2 population in this type of species are different from those in general species in which the genetic recombination occurs in meiosis of both male and female.

这类物种的杂交F2群体中杂合子基因型的与一般物种中雌雄个体的减数分裂细胞都发生遗传重纽的F2群体杂合子表型不同。

Genetic diversity analysis within and between the green peafowl and the blue peafowl populations demonstrated that the expected heterozygosity of two peafowl populations were 0.2482 and 0.2744, respectively. The inbreeding index, Reynolds' genetic distance and gene flow between the two populations were 0.078, 0.0603 and 3.896 respectively. These results indicate that the heterozygosity and the genetic diversity of these two peafowl populations were very low, and suggest a tendency towards intermixing.

蓝孔雀和绿孔雀群体间和群体内的遗传分析结果表明，绿孔雀和蓝孔雀两个群体的期望杂合度分别为0.7422和0.6943，群体间的遗传分化系数为0.078， Reynolds'遗传距离和基因流分别为0.0603和3.896，结果显示这两个孔雀群体的杂合度和遗传多样性水平都很低，且有相互混杂的趋势。

The relationship between the genetic deficiencies and hemorrhagic disorder were characterized. The homozygosity of the Thr359Met in the propositus with FⅦ: C activity 2% was related to severe clinical symptoms; The proband with double heterozygous lesions of Arg152Leu and one single nucleotide deletion at position 11487-9, combined with Arg304Trp in exon 8 with FⅦ activity 1% suffered severe clinical bleeding tendency. one proband with double heterozygous mutations (Agr304Trp and Arg304Gln) with 10% of FⅦ activities characterized asymptom. the heterozygous mutations (Thr359Met, Arg152Gln,-55C→T) with FⅦ: C 1%～5. 5% showed moderate or mild clinical symptoms.

其中8961 G＞T（Arg152Leu）和10966-8delC两种突变为国际首次报道，IFSla+5g＞a突变导致的异常剪接为国际首次报道。1个F7及F10基因联合缺陷家系，其中，F10基因28139 G＞T（Val384Phe）突变为国际首次报道；发现了1个由F7及组织因子(tissue factor，TF)两种基因联合缺陷导致的出血家系，其突变分别为F7基因启动子区-55C＞T杂合突变；TF 9363 C＞T（Arg131Trp）杂合多态性（频率2.63％）。6种F7基因突变发生在催化区；2种突变发生在裂解位点；1种发生在启动子区；1种突变发生在剪接位点，除一种缺失突变外，其余均为点突变；所有家系的基因突变都来自先证者的父亲和/或母亲。

In both HLA-B27 positive and negative groups, positive rate for HLA-B13/B40 was higher than that of HLA-B7/B40, implying that the heterozygotic frequency of B13 and B40 loci as well as the cross-reactivity of their antigens or both was higher.

无论在HLA-B27阳性还是阴性人群中，HLA-B13/B40的抗原阳性率远高于HLA-B7/B40的阳性率，说明B13和B40位点的杂合或交叉，远大于B7与B40之间的杂合或交叉。

In both HLA-B27 positive and negative groups, positive rate for HLA-B13/B40 was higher than that of HLA-B7/B40, implying that the heterozygotic frequency of B13 and B40 loci as well as the cross-reactivity of their antigens or both was higher.

无论在HLA-B27阳性还是阴性人群中，HLA-B13/B40的抗原阳性率远高于HLA-B7/B40的阳性率，说明B13和B40位点的杂合或交叉，远于B7与B40之间的杂合或交叉。

This invention pertains to compounds of Formula I, their N-oxides and suitable salts wherein A is O or S; G is a 5- or 6-membered heteroaromatic ring or a 5- or 6-membered nonaromatic heterocyclic ring optionally including one or two ring members selected from the group consisting of C, SO or S2, each ring optionally substituted with from one to four R; each J is independently a phenyl ring, a 5- or 6-membered heteroaromatic ring or an aromatic 8-, 9- or 10-membered fused carbobicyclic or heterobicyclic ring system, wherein each ring or ring system is optionally substituted with from one to four R; and R, R, R, R and n are as defined in the disclosure.

本发明涉及式I的化合物、其N-氧化物和适当盐，其中A是O或S；G是任选地包含一个或两个独立选自C、SO或S 2 的环成员的5-或6-员杂芳环或5-或6-员非芳族杂环，各环任选地被1-4个R 2 取代；各J独立地是苯环，5-或6-员杂芳环或芳族8-，9-或10-员稠合的碳二环或杂二环系，其中各环或环系任选地被1-4个R 3 取代；R 1 ，R 2 ，R 3 ，R 4 和n如说明书中定义。

But under the same conditions, the reactions of the complex (41) with organic lithium reagents give a kind of novel complexes in which the nucleophile is added to the a-carbon of the phthalazine ring.

然而含有桥羰基的2，3-二氮杂萘配位的羰基双铁络合物4l在相同的条件下与芳基锂试剂反应时，芳基锂却是亲核加成在氮杂环的α位羰上，生成一类结构独特的双氮双铁羰基络合物。

During the first cross, 4 different white monokaryotic strains were hybridized with 14 kinds of yellow monokaryotic ones to obtain light-yellow strains, which were then used to fruiting experiment. In the second cross, five kinds of yellow monokaryotic strains, which were observed monokaryotic fruit body, and 12 types of white monokaryotic ones were crossed to acquire hybrid strains, which were also to the experiment of fruit body formation.

第一轮杂交，运用4个不同的白色单核菌株和14个不同黄色单核杂交，获得系列浅黄色杂合子菌株，用于出菇实验；第二轮杂交，运用5个能够获得单核子实体的不同黄色单核菌株与12个不同的白色单核菌株相互杂交获得杂合子菌株，用于出菇实验。

It is one of the most dominant small mammals and plays an important role in keeping the balance of the alpine meadow ecosystem.The aim of this paper was to investigate the level of genetic diversity and also to test the hypothesis of IBD for this old species.Samples of plateau pikas were collected from four natural populations（Haiyan,Xidatan E,Xidatan W and Kunlunshan populations）.

采用多态信息含量、期望杂合度、观测杂合度、基因流和基因分化系数对种群及物种的遗传多样性水平进行分析；计算各种群间的遗传距离、遗传相似度以及遗传距离与地理距离的相关系数，并进行UPGMA聚类分析。

But we don't care about Battlegrounds.

但我们并不在乎沙场中的显露。

Ah! don't mention it, the butcher's shop is a horror.

啊！不用提了。提到肉，真是糟透了。