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The former is to prepare polymolybdates coordinated' directly by organic ligands using Na2MoO4 and MoO3 precursors; The latter plays emphasis on exploiting a simple and effective routine to synthesize Keggin polytungstates in which the transition metal or Si acts as the heteratom by reaction precursor Na2WO4.We have synthesized a 4,4'-bipyridine bridging dumbbell-like polymolybdates a metatungs...

前者主要是制备有机配体键合的多金属钼酸盐;后者重点是探索出一个简易、有效的合成过渡金属或主族元素硅作杂原子的Keggin多金属钨酸盐的方法,然后通过变换过渡金属或有机配体的种类探讨对产物结构的影响,再对所得化合物的结构和组成通过物理测试手段进行表征,同时研究其在光、电、磁等方面的性质。

Gene mutations were detected in 25 patients and a 18-year-old girl among 16 families. Trinucleotide repeats of CAG were 73~79. The fragments of abnormal alleles were 380~402bp, and all patients were heterozygous. The copy numbers of normal alleles were 18~40, fragments from 202~270bp. SCV reduction was much obvious compared to MCV, MCV and SCV in lower limb ?ere much more slow than that in upper's. BAEP, VEP were also delayed in latency. The anticipation in parental sex bias were much more obvioius than that in matental's. Cerebellar ataxia was most severe, the next were dysarthria and bulging eyes. Amytrophy was seen only in bed ridden patients. Cerebellar atrophy was more severe than brain stem, cord atrophy was n't observed in all MJD.

结果检出10个家系25例病人及1例症状前18岁女孩有MJD基因突变,CAG三核苷酸重复73~79次,异常等位基因片段长380~402bp,均为杂合子;正常人CAG三核苷酸重复18~40次,等位片段长200~270bp,电生理发现MJD的SCV减慢比MCV明显,而下肢的MCV、SCV又较上肢明显,BAEP、VEP均有不同程度的潜伏期延长或波的异常;MJD的父亲遗传早于母亲,进展也较块,临床以小脑性共济失调为突出症状,其次为构音障碍、突眼等,肌肉萎缩仅见于晚期病人;MRI示小脑萎缩较明显,脑干萎缩并不严重,未见明显的颈髓萎缩。

There were three isozyme (AMY1, AMY2 and AMY3) at the locus of amylase in Qinghai Merino, moreover, there were two genotypes of AMY2A and AMY2O at the AMY2. Monomorphism was tested at the locus of AMY in Gansu Alpine Merino. The degree of genetic variability estimated by Nei's expected average heterozygosity for the 6 blood protein loci was relatively higher in Gansu Alpine Merino and in Qinghai Merino than that in others, which indicated that there are higher genetic variations and richer genetic diversity in Alpine Merino.

从6个血液蛋白位点的Nei氏预期平均基因杂合度所估计的群体内的遗传变异以及与本研究其它群体的结果相比来看,甘肃高山细毛羊和青海细毛羊的群体内的遗传变异相对较大,而其它群体内的遗传变异则相对较小,说明高原型细毛羊群体内遗传变异程度较大,遗传多样性较丰富,具有较大的选择潜力,为高原型细毛羊进一步选育提高提供了遗传基础。

Objective To estimate the frequencies of HLA-B27, B7, B13 and B40 alleles in Chinese patients with ankylosing spondylitis or related disorders and to analyze heterozygotic frequencies among these loci and the cross-reactivities of their antigens.

目的 检测1194例初诊怀疑患强直性脊柱炎和其它关节性疾病患者的HLA-B27、B7、B13和B40位点抗原的分布,并分析这些位点的相互杂合和其抗原的交叉反应性。

Objective To estimate the frequencies of HLA-B27, B7, B13 and B40 alleles in Chinese patients with ankylosing spondylitis or related disorders and to analyze heterozygotic frequencies among these loci and the cross-reactivities of their antigens.

目的 检测1194例初诊怀疑患强直性脊柱炎和其它关节性减肥疾病治愈患者的HLA-B27、B7、B13和B40位点抗原的分布,并分析这些位点的相互杂合和其抗原的交叉反应性。

Objective: To explore the relationship between the genetic instability of microsatellite and the evolution of chronic myelogenous leukemia.

研究表明,许多肿瘤的发生和发展与微卫星DNAs的遗传不稳定性即基因组微卫星的不稳定性和染色体等位基因微卫星序列的杂合性缺失有关[1]。

To isolate and clone the tumor suppressor gene on chromosomal region 7q32 that corelated with the occurrence of human NPC,we detected the genotype of polymorphic microsatellite markers on 7q32 in 24 nasopharyngeal carcinoma biopsies and matched normal lymphocyte DNA.

为了分离和克隆定位于7q32染色体区域的与鼻咽癌发病有关的抑瘤基因,检测了鼻咽癌活检组织及配对外周血标本中7q32微卫星DNA多态性位点的基因型,发现在7q32区域存在30%左右的杂合性丢失。

A referencing flock comprsing eight paternal half-sib families totaling 374 individuals from Liangshan semi-fine wool sheep was utilised to analyze the allele frequency, polymorphism information content and heterozygosity of nine microsatellite from 2~ chromosome of sheep genome.And the research based on the daughter design to locate the putative QTL affecting wool traits was carried out in the linkage framework-mapping of 2~ chromosome.

本研究利用凉山半细毛羊的8个父系半同胞家系共374个个体,分析了绵羊基因组2号染色体上9个微卫星标记的等位基因频率、多态信息含量和群体杂合度,利用已构建的凉山半细毛羊2号染色体遗传连锁框架图谱,采用女儿设计对影响凉山半细毛羊8个羊毛性状的数量性状位点进行了定位研究。

Twelve microsatellite markers selected from the GENE-BANK were analyzed for polymorphism in silkies. Allele frequencies were estimated based on band presence or absence. Average heterozygosity and polymorphism information content were calculated by allele frequencies, and then, linkage analysis between character and markers by least squares means and the correlation among the 6 characters of egg traits in silkies were studied.

本试验选用12对微卫星引物,通过对丝羽乌骨鸡多态性扩增,计算出这些微卫星标记座位的等位基因频率、多态信息含量、群体杂合度;通过标记多态性与产蛋性状的最小二乘分析和多重比较,进行了分子标记与产蛋性状的相关分析,同时计算了产蛋性状间的表型相关。

The results were as follows: Firstly, the S-locus of Katy was heterozygous, and self-compatibility was dominant to self-incompatibility. Secondly, a very extensive segregation in self-pollinated fruiting rate, fertile flower rate and average fruit weight was observed in the F1 populations, and averages of these traits were lower than that of mid-parent means. Therefore, these traits were confirmed to be quantitative.

结果表明,(1)凯特杏的S基因位点为杂合型,自交亲和对自交不亲和为显性遗传;(2)3个杂交组合的自交坐果率、有效花比率及平均单果重等性状在F1中广泛分离,杂种群体的平均值低于亲中值,表现明显的衰退现象,表明这3个性状均为数量性状。

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