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Female mosaicism of the X chromosome has major implications for human health and disease and is the leading cause of female protection from X-linked genetic disorders.

女性作为X染色体的杂合子在人类的健康与疾病中及重要作用,并可避免X连锁遗产性疾病在女性中发生。

But the coatcolors of these mice varied wildly,ranging from yellow to mottled withevery combination in between.

但是这些小鼠的皮毛颜色差异很大,从黄色到各种颜色的杂合。

However sugarcane is a nonsexual propagation crop with highly ployploidy and complex genetic background,breeding pathogens-resistance cultivals by using traditoonal breeding techniques will be a formidable task.

但由于甘蔗是高度杂合、遗传背景复杂的无性繁殖作物,常规的抗病育种所需时间较长,盲目性大,效果也有限制。

Objective To explore the relation between HPV infection and lung cancer in female nonsmoker,and to investigate its relationship with LOH of FHIT gene.

目的 探讨人乳头瘤病毒感染与非吸烟女性肺癌的相关性,以及HPV感染对脆性组氨酸三联体基因杂合性丢失的影响。

The heterozygosity rate of the population was close to the expectation, indicating that the population had a normal genetic structure.

群体的杂合性比率接近期望值,表明该群体具有正常的遗传结构。

There is also a general lowering of vigor in inbred stock, which is especially pronounced amongst normally outbreeding populations.

而杂合型出现的频率降低,因而降低了种群基因的潜在可变性。

Methods Loss of heterozygosity on chromosome 9p21~22 was analyzed in 25 paired blood and tumor samples by using 11 high-density microsatellite polymorphic markers.

应用11个定位于9p21~22区域的高密度微卫星位点,检测25例低分化鼻咽癌患者的杂合性丢失。

Of six members in this family screened for this type of HPFH deletion,four were positive.Prenatal diagnosis of the fetus showed the same results as that of the propositus.

在此基础上,我们对该家庭的中间型地贫高风险胎儿进行了产前基因诊断,结果显示胎儿的基因型与先证者完全相同,为HPFH和β地贫双重杂合子,故建议终止妊娠。

Of 60 (22%) cases presented allelic loss in three or more consecutive adjacent chosen markers.

在所检测的病例中有22%出现连续三个或以上微卫星标志的杂合性丢失。

2N gametes are the result of meiotic mutation during micro- and mega-sporogenesis that bear the sporophytic rather than the gametophytic chromosome number. This paper reviewed the genetic markers including the morphologic, cytological, isozymes and DNA markers, which have been employed in the generation, inheritance, heterozygosity and marker-assisted breeding of 2n gametes based on the frequency of large pollen grains, cytological analyses, unexpected occurrence of polyploidy progeny and the associations between parents and progenies.

文章综述了植物2n配子发生及其遗传标记研究现状,论述涉及有关形态学标记、细胞学标记、同工酶标记乃至DNA标记等遗传标记在2n配子研究中的应用,指出通过花粉形态观察、大小孢子母细胞减数分裂行为观察、杂种后代倍性鉴定以及亲子分子标记相关分析等,对2n配子发生、2n配子遗传类型与杂合性以及2n配子在育种实践中的有效性等进行研究。

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