杂合性

Objective:To investigate the relationship between loss of heterozygosity of the allele gene at 3p14 and the pathogenesis of NSCLC.

目的 探讨非小细胞肺癌细胞中3p14位点等位基因的杂合性丢失(loss of heterozygosity，LOH)与NSCLC发生及发展之间的相关性。

Results Of the 25 cases, 17(68.0%) showed LOH at one or more loci.

结果 25例患者中，有17例存在一个或多个位点的杂合性丢失，占68.0%。

Objective To explore the relation between HPV infection and lung cancer in female nonsmoker,and to investigate its relationship with LOH of FHIT gene.

目的 探讨人乳头瘤病毒感染与非吸烟女性肺癌的相关性，以及HPV感染对脆性组氨酸三联体基因杂合性丢失的影响。

The heterozygosity rate of the population was close to the expectation, indicating that the population had a normal genetic structure.

群体的杂合性比率接近期望值，表明该群体具有正常的遗传结构。

Methods Loss of heterozygosity on chromosome 9p21～22 was analyzed in 25 paired blood and tumor samples by using 11 high-density microsatellite polymorphic markers.

应用11个定位于9p21～22区域的高密度微卫星位点，检测25例低分化鼻咽癌患者的杂合性丢失。

Of 60 (22%) cases presented allelic loss in three or more consecutive adjacent chosen markers.

在所检测的病例中有22％出现连续三个或以上微卫星标志的杂合性丢失。

Nasopharyngeal carcinoma is an endemic cancer with particulargeographic and ethnic distribution within southern China, most frequently, withinGuangdong province. Etiologically, the disease involves multiple factors includinggenetic, Epstein-Barr viral, as well as other food and environmental factors.Cytogenetic studies have revealed that loss of heterozygosity on chromosome3p occurred in as many as 95 - 100％ of NPCs and 75％ of precancerous lesions,suggesting the presence of NPC associated tumor suppressor genes.

鼻咽癌(Nasopharyngeal carcinoma，NPC)是中国南部、尤其是广东省最为常见的恶性肿瘤，其发病与遗传因素、EB病毒感染、以及环境和饮食等多种因素有关。3号染色体短臂(3p)在高达95-100％的鼻咽癌和75％的癌前病变中发生杂合性丢失(Loss of heterozygosity，LOH)，提示3p缺失区域中存在与鼻咽癌发生密切相关的抑癌基因。

But to make good use of them, their genetic characteristics and germplasm relationship with Chinese inbred lines representing different heterotic groups should be studied.

本研究采用传统的配合力和杂种优势分析与现代的SSR分子标记技术相结合的方法，探讨引进南斯拉夫玉米自交系与我国不同优势类群骨干自交系的配合力、杂种优势、遗传距离和杂合性，为引进自交系的高效合理利用提供理论依据；并通过各项遗传指标与F1产量的相关分析，探讨各项指标预测杂种优势的可行性和效果。

In this study, through the traditional methods, analysis of combining ability and heterosis, and modern SSR marker technique, the combining ability, heterosis, genetic distance and heterozygosity between introduced Yugoslavia inbreds and important lines representing different heterotic groups in our country were studied, which will greatly influence to make full use of those indroduced lines.

本研究采用传统的配合力和杂种优势分析与现代的SSR分子标记技术相结合的方法，探讨引进南斯拉夫玉米自交系与我国不同优势类群骨干自交系的配合力、杂种优势、遗传距离和杂合性，为引进自交系的高效合理利用提供理论依据；并通过各项遗传指标与F1产量的相关分析，探讨各项指标预测杂种优势的可行性和效果。

Heterosis is based on the heterozygosity of heterozygotic genotypes.

育种实践表明，杂种优势的遗传基础是杂交种基因型的杂合性。

For a big chunk of credit-card losses; the number of filings (and thus charge-off rates) would be rising again, whether

年美国个人破产法的一个改动使得破产登记急速下降，而后引起了信用卡大规模的亏损。

Eph. 4:23 And that you be renewed in the spirit of your mind

弗四23 而在你们心思的灵里得以更新