机体

ConclusionThe Astragalus injection may improve the hypercoagulable state, enhance the anti-oxidant ability, reduce urinary protein leakage.

黄芪注射液能改善小儿肾病综合征血液的高凝状态，提高机体抗氧化能力，减少尿蛋白的漏出。

Canine distemper during the first heat in the high doses of hyperimmune serum, can enhance the body enough antibodies to prevent clinical symptoms, therapeutic purposes.

在犬瘟热最初发热期间给予大剂量的高免血清，可以使机体增强足够的抗体，防止出现临床症状，达到治疗目的。

Zeta potential was -44.23 millivolt. Viscosity was 1.83 mpa. All of which were coincided with physical desire. In addition, the tests of PHGF liposomes including irritation, hemolysis, pyrogen, anomaly toxicity and hypersensibility, proved that the preparation reached the standard of intravenous injection entirely. Taking glutamic pyruvic transaminase and malondialdehyde in mice as index, studies on pharmacodynamics after hepatic injure caused by tetrachloromethane in mice indicated that GPT level (P.001) and MDA yieldment P

以小鼠CCli急性中毒性肝损伤为模型，以动物血清中谷丙转氨酶（GP水平与肝脏中丙二醛p A烨成量为指标，进行PHGF脂质体的药效学试验，结果表明P＊＊F脂质体能显著降低GP T水平o＜0刀01）与MD A 生成量厌＜o.05）；大鼠组织形态的观察表明高剂量＊＊＊F脂质体能使肝脏 0 内皮细胞增生活跃，提高肝细胞的免疫功能，对受损肝细胞具有修复作用；同样小鼠碳廓清试验也显示PHGF脂质体较市售粉针具有更好的机体免 p 疫作用o功刀01），达到制剂设计目的，获得较好的结果。

Organism defense hypofunction hypochlorhydria, immune globulin↓,SIgA ↓, normal flora

机体防御功能较差胃酸↓，免疫球蛋白↓，SIgA ↓，正常菌丛

These experiments indicate that an idiotype change in TCR can arose the host's anti-idiotype reaction and induce suppressor T cells.

其机理可能与活化T细胞表面TCR分子的独特型改变诱发机体的抗独特型反应有关。

Restrictive changes of TCR Vp repertoire and clonal expanded T cells could be found in peripheral blood T cells from patients with T-ALL. However, the clonal expanded T cells' property (clonal expansion leukemic cells or leukemia antigen-specific expansion T cells) should be further characterized. It may play a certain role on detection of minimal residual disease and design of anti-leukemia idiotypic vaccine. The dominant utilization of TCR VjJ repertoire could be found in peripheral blood T cells from patients with B-ALL, meanwhile clonal expansive T cells were existed. It may be a feature of the host immune response for leukemia-associated antigen. The clonal expansive tendency of T cells in V021 and VP23 subfamilies was rather obvious, which may be correlated with certain malignant B-cell clone. The CDR3 sequences of monoclonal expansive T cell in T cell strains were different, which was the base of developing DNA vaccine.

T-ALL患者外周血T细胞的TCR Vβ谱系出现限制性改变，均可检测到克隆性增殖T细胞，尚需进一步鉴定其性质(肿瘤性或抗原特异性增殖)，对于研究微小残留病变检测和设计抗白血病独特型疫苗均有一定的意义。B-ALL病人外周血T细胞的TCR Vβ谱系呈现优势利用的特点，并存在克隆性增殖的T细胞，这可能是机体对白血病相关抗原产生的特异性免疫反应；Vβ21和Vβ23亚家族T细胞发生克隆增殖改变的趋向性比较明显，可能与B-ALL相关抗原刺激有关。T细胞株中检测到的肿瘤克隆其CDR3序列具有高度的特异性，是构建DNA疫苗的基础。

Nucleoprotein is also a major immunogenetic antigen for SARS; however, several tests have shown that N protein had the reactivity with other coronavirus positive sera. It is therefore an advantage of S protein as recombinant target antigen for SARS serum diagnosis compared with recombinant N protein. Moreover, S protein has been shown to be the major antigenic determinant that induces neutralizing antibodies and protective immunity to SARS-CoV, so it is also important in designing SARS genetic engineering vaccine.

SARS-CoV S 蛋白由1255 个氨基酸组成，体外表达如此大的蛋白很困难，而且表达蛋白的可溶性不高；其次，实验已经证实，全长S 蛋白含有大量无关的表位，致使表达的全长S蛋白对SARS 阳性血清的检出率低于S 蛋白片段；另外作为疫苗研究，S 蛋白上大量无关表位作为异体蛋白进入体内，会引发机体的过度免疫反应，这也是SARS-CoV 可能的致病机理之一。

In Picomaviridae, 3D protein was RNA dependent RNA polymerase, and had been applied indifferential diagnosis of FMDV infection, and other picornaviruses.

在PTV病毒中，3D蛋白是具有RNA依赖RNA聚合酶(RNA dependent RNA polymerase，RDRP)活性蛋白，能介导机体产生特异性的抗体。

The majority of S-100 +DCs, often with delicate and fewer processes, were located in interfollicular area in Peyer's patches.

DC广泛分布于淋巴组织和非淋巴组织中，是机体内目前已知的功能最强的抗原提呈细胞[2 ] 。

OBJECTIVE: To observe dynamically the level of white blood cell and its morphological changes using automatic blood cell analyzer to evaluate its relationship with infection, immunosuppressive intoxation and acute rejection.

目的：应用全自动血细胞分析仪动态监测肾移植患者外周血白细胞数量和形态的变化，分析其与移植后机体感染、免疫抑制剂中毒及急件排斥反应发生的关系。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。