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术后治疗

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Results 6 cases died perioperatively with a mortality of 6.21%,inc luding 3 with multiple system organ failure,2 wiuh low cardiac output syndrome,1 with renal failure.Among the alive cases,6 suffered from low cardiac output syn drome,6 with multiple system organ failure and 1 with renal failure,but all of t hem were successfully rescued by positive therapy,18 suffered from pulmonary inf ection and 3 with incision infection postoperatively,6 with tracheotomy,1 with l ower limbs necrosis and amputation.

结果 围术期死亡6例,病死率6.21%,其中多系统器官衰竭3例,低心输出量综合征2例,肾功能衰竭1例;存活患者中出现低心输出量综合征6例,并发多系统器官衰竭6例和肾功能衰竭1例,经积极治疗后治愈;术后出现肺部感染18例;手术切口感染3例;气管切开6例;肢体坏死而截肢1 例。

Methods 60 patients with severe traumatic brain injury and brain swelling treated by decompressive craniectomy were randomly divided into lattice duraplasty and routine method groups and were compared the imaging features after operation.

60例重型颅脑损伤伴脑肿胀患者分为两组,均行开颅去大骨瓣减压手术治疗,术中分别应用硬脑膜网格成形与常规方法减压,统计两组患者术后影像学表现并进行对比分析。

Objective To study the relationship of endangium proliferation and the expression of metalloproteinases and tissue inhibitors of metalloproteinases after angioplasty of iliac artery in rabbits to investigate the probable mechanism of composite Danshen pill in prevention and treatment of restenosisMethods 30 white male rabbits of Japan (the average body weight was 25~30 kg)were randomly divided into 3 groups:normal control group,model group (intima destroyed by balloon and given hypercholesterol diet),CDP group (intima destroyed by balloon and given hypercholesterol diet plus drug CDP 150 mg/d),10 ones each groupResults The results of iliac artery angiogram and the analysis of pathology:there were lumens stenosis,thinner intima,smaller intima area,in CDP group compared with those in model group,and ratio of intima and tunica media thickness and area among each group (P<001)Immunohistochemistry analysis:the MMP2,MMP9,TIMP1,TIMP2 in model group significantly increased than those in control group (P<001)The CDP group had lower MMP2 and MMP9 expression,higher TIMP1 and TIMP2 expression,and increased MMP2/TIMP1,MMP9/TIMP2 than model group (P<001)The thickening of vascular neointima and stenosis degree of vascular lumen were relevant to MMP2 and MMP9 (r=0896,P<001)Conclusions MMP and TIMP play the very important role in the restenosis process of arteryCDP could inhibit the thickness of vascular neointima after balloon injury,the probable mechanism of which may be inhibiting collagen formation,smooth muscle immigration and decreasing hyperplasia of intima by interfering expression of MMPs and TIMPs

目的 研究兔髂动脉成形术后血管内膜增生和基质金属蛋白酶及其抑制物表达之间的关系,探讨复方丹参滴丸预防再狭窄的可能机制。方法健康成年二级雄性日本大耳白兔30只,平均体重25~30 kg。随机分为3组:正常对照组10只,模型组10只(球囊内膜剥脱加高胆固醇饮食),治疗组10只(球囊内膜剥脱加高胆固醇饮食以及复方丹参滴丸150 mg/d)。结果兔髂动脉造影、血管病理图像分析检测结果:①复方丹参滴丸组较模型组血管造影示管腔直径狭窄、内膜厚度减少、内膜面积减少、内膜厚度和中膜厚度比、面积比,各组之间有显著性差异(P<001)。②免疫组化分析:模型组MMP2、MMP9、TIMP1、TIMP2表达均高于对照组(P<001);复方丹参滴丸组MMP2、MMP9的表达低于模型组,而TIMP1、TIMP2的表达高于模型组;TIMP1/MMP2、TIMP2/MMP9明显增加,差异有显著性(P<001)。③内膜的增生以及管腔的狭窄程度与MMP2、MMP9有很好的相关性(r=0896,P<001)。结论 MMP和TIMP在再狭窄形成中起重要作用;复方丹参滴丸能够明显抑制血管损伤后的内膜增生,可能的机制是通过影响金属蛋白酶MMP2、MMP9及其抑制物TIMP1、TIMP2的表达从而抑制胶原的生成、平滑肌的迁移、增生,而减少内膜的增生。

Nm23, VEGF and ER can be used as markers in the prognostication of breast cancer. Patients with nm23, ER positive and VEGF negative have better postoperative prognosis. Expression of ER can be used as an early marker, Postmenopausal breast cancer patient should apply more active endocrinotherapy.

我们认为,乳腺癌的发生与癌组织中的 nln23、pZI VEGF和 ER过度表达有密切相关,nln23阳性、VEGF阴性和 ER 阳性的乳腺癌术后预后较好,癌组织中的m23、VE GF和ER表达可以作为判断乳腺癌预后的指标;ER的表达可以作为乳腺癌的早期标记物;绝经后乳腺癌病人应采取更积极的内分泌治疗。

energetic combined therapy and retrospective analysis were done on 9 patients with postoperative endothoracic anastomotic fistula 5 years after operation.

对9例食管、贲门癌术后5年内吻合口瘘病人采用积极的综合治疗并进行回顾性分析。

Objective To evaluate the efficacy of endovenous laser treatment in the treatment of varicose veins in lower limbs.

目的 总结静脉腔内激光治疗(endovenous laser treatment,EVLT)下肢静脉曲张的疗效和术后并发症。

After surgical reconstruction, improvement of extraocular movement limitation was found in 16 patients (88%); improvement of vision in 14 cases (60%); improvement of enophthalmos in 6 cases (26%). 14 cases with infraorbital hypoesthesia showed improvement in 8 patients.

手术治疗病例中,外眼肌活动改善者16例(88%);视力进步或不变者12例(66%);眼球内陷改善者6例(33%);14例术前有眼窝下神经知觉麻痹,其中8例於术后获得改善。

Among them, 39 cases were in low grade ,31 cases in high grade and 4 cases had the ependyma tumor. All the patients received radiotherapy in 3-4 weeks after operation. Thirty-one cases were performed total resection, 38 cases balk-resection and 5 cases partial resection.

对脑胶质瘤低级别39例、高级别31例及室管膜瘤4例均进行手术切除,其中肉眼肿块全切31例,大部切除38例,部分切除5例,均在手术后3~4周内接受放射治疗。

The ependymoma was confirmed by postoperative pathology.McCormick grading scale:gradeⅠ in 23 cases,gradeⅡ 16 cases,grade Ⅲ 2 cases .31 cases were followed-up for a year after operation.

术后病理证实均为室管膜瘤。31例获得为期1年的随访,3例肿瘤次全切除患者1年内复发,再次行手术治疗;肿瘤全切除者无复发。

Results: Occurrence of postoperative complications in 256 breast cancer patients was 22.7%,[Including epidermal necrosis in 11(4.3%), liquid accumulated under epiderm in 16(6.2%), light degree swell of the illed lateral upper arm in 31(12.1%)], were all cured after medical treatment.

结果:256例乳腺癌术后并发症发生率为22.7%,其中皮瓣坏死11例(4.3%),皮下积液16例(6.2%),患侧上肢轻度肿胀31例(12.1%),经治疗均获痊愈。

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