末端

Methods .- Immouno histochemical technique was used to observe Fas and FasL expression in normal and cancerous tissues.

采用免疫组织化学技术观察Fas及FasL蛋白的表达，用原位末端标记法检测细胞凋亡。

The renal function and histopathological changes were evaluated at 1,2,4,8,12,16,26 and 40 weeks after operation finished.

在1、2、4、8、12、16、26和40周，用原位末端标记法、免疫组化、RT-PCR、Western—blot分别检测细胞凋亡、caspase-3，-8，-9的mRNA和蛋白质的水平。

We have investigated the conformational features of four short peptide fragments of Staphylococcal nuclease by homonuclear two-dimensional NMR and circular dichroism with a view to examining the early events in the folding process of SNase.

本论文工作用四个金黄色葡萄球菌核酸酶N-末端短片段作为新生肽链折叠的模型，用同核二维核磁共振谱和远紫外圆二色谱研究了它们的溶液构象特征。

A small hooklike projection or process,as at the end of a bone .

翅钩；钩形突一种小的钩状突起或隆起，比如在头的末端

During the titration of Ca〓CaM by La〓, the hydrid complex La〓Ca〓CaM forms as the intermediate species. La〓 can bind to calmodulin with high affinity (K〓=10nmol/L) and obvious cooperation between the two global domains. The secondary structure of La〓CaM and Ca〓CaM are highly similar, but there are obvious differences in ternary structures. Excessive La〓 changes the conformation of calmodulin greatly.

实验结果表明，La〓在钙调蛋白上的结合位点与钙离子相同；在结合顺序上La〓以较小的优势先结合在钙调蛋白的N末端；La〓Ca〓CaM是La〓与含钙的钙调蛋白作用时的主要产物；La〓强烈地与钙调蛋白结合，其解离常数约10nmol/L，各个结合位点之间存在明显的协同效应；La〓CaM与Ca〓CaM在二级结构上高度相似，但是在高级结构上有明显差异。

It looks like that the molecular weight of these immunopeptides were very small, and it also showed that the hydrophobe amino acid on the bottom and alkaline amino acid were important structurals of the immunopeptides.

论文主要研究结论如下：目前已报道的140余种免疫活性肽其相对分子质量都较小，通常在肽链中含有碱性氨基酸或在末端具有疏水性氨基酸。

However, this hydrophobic end of a detergent molecule is attracted to substances such as fats.

然而，一个洗涤剂分子的这个疏水末端被吸引对物质例如油脂。

Results are as followed:1 Exposure of HELF cells to BP caused c-Jun activation,and increased the activity of MAPK,PI-3K,p53 and cyclin D1 pathway.2 BP-induced c-Jun activation was inhibited by dominant negative mutants of extracellular signal-regulated protein kinase or c-Jun NH_2-terminal kinase,but not by p38,impling that JNK and ERK pathways medicate c-Jun activation induced by BP.3 Overexpression of dominant-negative mutants PI-3K and Akt potently blocked phosphorylations of c-Jun and ERK,but not JNK in response to BP,suggesting that PI-3K/Akt pathway positively regulates BP-induced c-Jun activation through ERK.4 Inhibition of p53 by its chemical or molecular inhibitor markedly increased the phosphorylation levels of c-Jun,Akt and ERK upon BP stimulation,indicating that p53 negatively medicates BP-induced c-Jun activation through PI-3K/Akt/ERK pathway.5 The cell lines expressed TAM67 exhibits no significant affecting normal cell growth properties.6 TAM67 was able to significantly block G_1-S transition and subsequent cell proliferation,suggesting that c-Jun is essential for cell cycle alternations elicited by BP.7 Overexpression of TAM67 impaired BP-induced cyclin D1 activation,decreasing expression of E2F1 and pRb,indicating that c-Jun participates in the modulation of BP-induced activation of cyclin D1/pRb/E2F1 pathway.8 Stably expression of TAM67 led to the increases in the expression levels of p53 and p21,elevating phosphorylation level of p53,clearly indicating that c-Jun regulates p53/p21 pathway activation induced by BRCollectively,PI3K/Akt/ERK pathway mediated BP-induced c-Jun activation through p53-dependent mechanism.

结果显示：1BP刺激细胞可促进c-Jun活化，并伴随着MAPK、PI-3K、p53和cyclinD1通路各组成成分的活性增强。2利用MAPK通路的显性失活突变体分别阻断细胞外信号调节激酶和c-Jun氨基末端激酶活性，均可明显抑制BP诱导的c-Jun活化，但阻断p38活性对BP引起的c-Jun活化无明显影响，提示JNK和ERK通路参与调控BP诱导的c-Jun活化。3过表达PI-3K和Akt的显性失活突变体也可显著抑制BP诱导的c-Jun活化，并降低磷酸化ERK的表达水平，但对磷酸化JNK的表达水平无明显影响，说明PI-3K/Akt通路通过ERK正性调控了BP诱导的c-Jun活化。4p53的化学/分子抑制剂能使BP作用的细胞内c-Jun活性明显增加，并同时诱导Akt和ERK的磷酸化水平的升高，表明p53可通过PI-3K/Akt/ERK通路对BP诱导的c-Jun活化进行负性调控。5随后观察转染细胞的生长情况，发现TAM67对细胞正常生长和形态无明显影响。6稳定表达TAM67可有效抑制BP诱导的S期细胞数的增加，提示c-Jun在BP致细胞周期改变的过程中发挥了重要作用。7TAM67过表达能够抑制BP诱导的cyclin D1活化，降低磷酸化Rb以及E2F1蛋白表达水平，表明c-Jun参与调控BP诱导的cyclin D1/Rb/E2F1通路的活化。8过表达TAM67可使BP刺激的细胞中p53、p21总蛋白以及p53磷酸化的表达水平明显升高，可见c-Jun也参与调控BP诱导的p53/p21通路活化。

Rodent incisors are known to be continuously growing teeth that are maintained by both the cell-proliferation at the apical end and the attrition of the incisal edge.

啮齿动物的切牙终生不断生长，其高度通过切端磨损及根尖末端的细胞增殖来维持。

Oncogenic transformation of c-abl to v-abl occurs by insertional activation that results in deletions of specific N-terminal amino acids.

由abl癌基因编码的转化蛋白。c-abl到v-abl的致癌性转化由于插入激活而发生并引起特异性氨基末端氨基酸删除。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失