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Several other poster presentations reinforced the message that once-weekly epoetin was effective, although none of these others had a comparator dose. Two posters presented results from meta-analyses of epoetin alfa clinical trials. One was carried out by Pere Gascon, MD, PhD, and colleagues, from the University of Barcelona, in Spain, and involved 4296 patients with mixed tumor types, while the other, reported by Mario Dicato, MD, from the Luxembourg Medical Center, involved 2019 patients with breast cancer. Both concluded that 40,000-IU epoetin alfa is effective and well tolerated; it ameliorates the impact of chemotherapy on hemoglobin and improves quality of life, thus representing "good anemia management," the researchers concluded.

许多其他的壁报研究同样证实每周投予一次红血球生成素是有效的,虽然其他研究中未使用比较组;另两项比较红血球生成素阿法临床试验结果的综合分析,一项是由Pere Gascon医师与其来自西班牙巴塞隆纳大学的同事,收纳了4,296位各种肿瘤种类病患的研究;另一篇是来自Luxembourg医学中心Mario Dicato医师,收纳2,019位乳癌病患的研究,这两项研究的结论都是40,000单位的红血球生成素阿法同样有效、且耐受性佳;该疗法降低化学疗法对血红素的不良影响,且改善了生活品质,因此可以说为是「良好贫血处理」的标竿。

Asked by Medscape Oncolo gy to comment on this finding, Jayne Franklyn, MD, PhD, from Queen Elizabeth Hospital, in Birmingham, United Kingdom, who was not involved with the study, said:"This is an important study, as it involved a large number of patients with a relatively rare form of thyroid cancer, specifically looking at those with the sporadic or noninherited variety of this cancer, and it presents the intriguing possibility that the presence of the mutation is associated with a prediction of tumor behavior and therefore prognosis."

Medscape肿瘤学邀请英国伊丽莎白皇后医院的Jayne Franklyn医师对此发现进行评论,未参与此研究的Franklyn医师表示,这是一个重要的研究,因为它纳入了此一少见甲状腺癌的许多病患,特别是此癌症的偶发或者非遗传变化,且展现出突变与预后有关的可能性;此外,该研究有潜在的临床冲击,但是首先,这些发现需要有其他研究证实重现;这项研究也指出各种甲状腺癌的基因突变与基因表现可提供预后资讯的远景。

Asked by Medscape Oncology to comment on this finding, Jayne Franklyn, MD, PhD, from Queen Elizabeth Hospital, in Birmingham, United Kingdom, who was not involved with the study, said: \"This is an important study, as it involved a large number of patients with a relatively rare form of thyroid cancer, specifically looking at those with the sporadic or noninherited variety of this cancer, and it presents the intriguing possibility that the presence of the mutation is associated with a prediction of tumor behavior and therefore prognosis.\"

Medscape肿瘤学邀请英国伊丽莎白皇后医院的Jayne Franklyn医师对此发现进行评论,未参与此研究的Franklyn医师表示,这是一个重要的研究,因為它纳入了此一少见甲状腺癌的许多病患,特别是此癌症的偶发或者非遗传变化,且展现出突变与预后有关的可能性;此外,该研究有潜在的临床冲击,但是首先,这些发现需要有其他研究证实重现;这项研究也指出各种甲状腺癌的基因突变与基因表现可提供预后资讯的远景。

Though the Waddington and von Bertalanffy programs have not been confirmed in the typical accomplishments and representations in molecular biology in general, and molecular genetics in particular, there are interesting advances that fall between those searches for broad theories couched in mathematically precise differential equation form, and the narrow classes of mechanisms, usually described in qualitative multilevel causal language, that constitute the vast majority of current biomedical explainers.

朋友,追加点分如何?虽然Waddington和冯Bertalanffy节目在分子生物学和分子遗传学的典型的成就和表示法未一般来说,被证实特别是,有下跌在那些查寻之间以数学上精确微分方程形式横卧的宽广的理论的有趣的前进和在定性多重原因语言,通常描述的机制狭窄的类,构成绝大多数的当前生物医学的解说员。

Several other poster presentations reinforced the message that once-weekly epoetin was effective, although none of these others had a comparator dose. Two posters presented results from meta-analyses of epoetin alfa clinical trials. One was carried out by Pere Gascon, MD, PhD, and colleagues, from the University of Barcelona, in Spain, and involved 4296 patients with mixed tumor types, while the other, reported by Mario Dicato, MD, from the Luxembourg Medical Center, involved 2019 patients with breast cancer. Both concluded that 40,000-IU epoetin alfa is effective and well tolerated; it ameliorates the impact of chemotherapy on hemoglobin and improves quality of life, thus representing "good anemia management," the researchers concluded.

许多其它的墙报研究同样证实每周投予一次红血球生成素是有效的,虽然其它研究中未使用比较组;另两项比较红血球生成素阿法临床试验结果的综合分析,一项是由Pere Gascon医师与其来自西班牙巴塞隆纳大学的同事,收纳了4,296位各种肿瘤种类病患的研究;另一篇是来自Luxembourg医学中心Mario Dicato医师,收纳2,019位乳癌病患的研究,这两项研究的结论都是40,000单位的红血球生成素阿法同样有效、且耐受性佳;该疗法降低化学疗法对血红素的不良影响,且改善了生活质量,因此可以说为是「良好贫血处理」的标竿。

It's regarded as a dentin specific protein, The gene structure and the expression pattern of DSPP at transcript level are well known in recent years, however, the expression pattern of DSPP protein, and it's possible role during tooth development and dental pulp reparation after injury are not clear yet.

近年来,DSPP的基因结构及mRNA水平的表达模式已较清楚。蛋白印迹实验证实小鼠牙胚中有DSPP蛋白的存在。但是,DSPP在蛋白水平的表达模式如何?它的生物学功能和作用机制是什么?它在牙髓损伤修复中的作用又如何?目前国内外均未见报道。这些问题的研究,对我们在该蛋白后基因水平的了解具有重要意义,也为我们深入了解牙本质生物矿化机制、对牙体组织疾病和损伤进行生物性防治提供理论依据。

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