未被显示的

The results indicated that the pesticide could be distributed through the body and cumulated in peripheral compartment relatively,but it could be eliminated rapidly.With parameters such as t1/2α valued 3.40min,t1/2β 59.03min and Cl 0.018ml·min-1,Its metabolism followed two-compartment open model after administration of 10 mg/kg.It was primary distributed to blood-riched organs and fat tissues and ready to be biotransformed.The metabolic product were detected in choler,which had stronger polarity with retention time 4.25min;and no parent compound was found in both urine and faeces.Key words: Toxicokinetics;Fenamithion;Organophosphorus pesticide

结果显示：螨胺磷在体内全身分布，并有周室富集，消除较快，在10mg/kg静脉注射呈二室模型，t1/2α为3.40min，t1／2β为59.03min，全身清除率Cl0.018ml·min-1；螨胺磷主要分布于血流量大的器官及脂肪组织；螨胺磷在体内不稳定，能被肝脏代谢转化成极性更高的化合物后经由胆汁排出，该成分可在同样的色谱条件下被分离，峰保留时间4.25min；粪尿中均未检出原药。

A549 cells are more sensitive to CDDP-induced apoptosis(P.01) and less sensitive to THP andβ-Ele-induced apoptosis than A375p(P.01, P.05 respectively). Condensation and crack of nucleus and apoptotic bodies appeared in apoptotic cells of A549 and A375p cell lines in all treated groups and necrocytosis were to be seen in some groups. Fluorescence imaging experiments demonstrated that accumulation of iASPP in cytoplasm but little distribution in nucleus in all groups. untreated groups in two cell lines presented a bright-green colour,followed by CDDP-treated groups,and THP-treated groups is the darkest one in all groups.

免疫荧光显示，未加药物处理的A549和A375p细胞胞质染色均匀呈亮绿色，核区较暗；CDDP及β-Ele处理组细胞为暗绿色，其中可见皱缩的凋亡细胞；THP处理的细胞胞质荧光弱呈灰绿色，由于THP嵌入DNA自发红色荧光与二抗的绿色荧光中和，胞核被染成桔红色，结果提示药物处理后A549和A375p细胞中iASPP的表达有不同程度的下降。

It was impregnated into E glass cloth and heated to give a prepreg showing good appearance and no tack.

它未怀孕入E擦镜布并且被加热给显示好出现和大头钉的prepreg。

Calcium sulfate has been used for bone regenation in oral medicine. Osteopontin, a marker molecule, expressed by osteoblast, plays multiple roles in human body. However, the effect of calcium sulfate on osteopontin expressed in osteoblasts is unclear. In this study, U-2 osteosarcoma osteoblastic cells were cultured in 0, 0.5, 1, or 10 μM calcium sulfate hemihydrate. There was no effect in the proliferation of cells, suggesting that calcium sulfate up to 10 μM is biocompatible. The cells and conditioned media were collected for analyzing mRNA and protein levels of osteopontin by reverse-transcription polymerase chain reaction and Western blot, respectively.

硫酸钙用於口腔医学中的骨头再生已经有多年历史，骨桥素是一种被骨母细胞分泌且在人体扮演重要多重角色的标的分子，然而，硫酸钙在骨母细胞分泌硫酸钙上的影响仍未明朗，在本实验之中，培养U-2骨肉瘤类骨母细胞(U-2 osteosarcoma osteoblastic cells)於0、0.5、1、10 μM的硫酸钙之中，在细胞数目的复制上，四种硫酸钙浓度并无影响，显示出U-2骨肉瘤类骨母细胞培养於10 μM的硫酸钙仍是生物相容性的。

Neutralizing potency of the patent recombinant anti-rabies virus McAbs, SO57 and SOJB,have been investigated broadly to different rabies virus strains in various animal models.100% Chinese Hamsters could be protected by 100IU/kg SO57 against China prevalent street rabies virus named SBD.We firstly established the mouse model to simulate human postexposure prophylaxis by rabies virus and found SO57 had the same function with HRIG against CVS or three China typical street rabies viruses.However,HRIG could not 100% protect the mice challenged with SBD street virus,rabies virus vaccine alone could not save life from rabies virus infection.The cocktail containing SOJB and SO57(1:1) did not do better than SO57 alone.

用不同的动物模型研究了具有专利的重组人抗狂犬病病毒单克隆抗体SO57、SOJB对不同狂犬病病毒株的中和作用，100IU/kg的SO57能100%保护被中国街毒株SBD攻击的中国仓鼠；首次用小鼠模型模拟人体被狂犬病病毒攻击后的治疗情况，在小鼠被CVS及中国街毒代表株攻击后，SO57与HRIG具有相近的对小鼠的暴露后保护作用；同时结果显示HRIG对SBD株攻击的保护率不能到达100%，仅使用疫苗是不能对感染病毒的小鼠百分之百的保护；SOJB与SO57 1：1联合使用未显示比SO57单独使用更好的保护效果。

Leptotyphlops carlae is the world's smallest species of snake, with adults averaging just under four inches in length.

这张未标明拍摄日期的照片显示，被命名为&Leptotyphlops carlae&的蛇在一枚0.25美元硬币上休息。

No entire nitrendipine crystals were observed visually in SEM photos. The results of X-ray diffraction and differential scanning calorimetry analysis indicated that the crystalline form of nitrendipine was highly dispersed in microspheres, so as amorphous state. The drug release rate of microspheres could be controlled with adjusting the ratio of solid dispersion carriers and retarding agents formulated. The agitation speed and temperature of the preparation process have distinct effect on micromeritic properties of microspheres. The release profiles of the microspheres were mainly affected by the stirring rate of paddle, the concentration of SDS and pH of dissolution medium. Cooling speed and time, however, have no evident influence on the drug release rate of the microspheres. The dissolution data showed that the mechanism of drug release from microsphers was mainly diffusion-controlled. The incorporation efficiencies of 3 batches sample were exceed 96. 8％, which implied that the current method was suitable for design sustained-release dosage form for poorly water-soluble drug.

在扫描电子显微镜下观察，在微球内外未发现尼群地平的完整结晶，X-射线粉末衍射和差示扫描量热试验结果也显示，尼群地平已经被高度分散在微球中；微球的释药速度可通过调整处方中固体分散体载体和阻滞剂的比例控制；制备温度和搅拌速度对微球的质量影响较大；溶出仪的搅拌速度，释放介质的浓度和pH对微球的释放有较大的影响；制备过程中的冷却速度和冷却时间对微球的释放行为影响不很明显；方程拟合的结果表明缓释微球的释药行为符合扩散机制；测定三批微球样品的包封率均在96.8％以上，表明该法适合于制备难溶性药物的缓释微球。

Whereas osteoporosis is unassociated with bone pain, osteomalacia has been associated with isolated or generalized bone pain.39,40 The cause is thought to be hydration of the demineralized gelatin matrix beneath the periosteum; the hydrated matrix pushes outward on the periosteum, causing throbbing, aching pain.7 Osteomalacia can often be diagnosed by using moderate force to press the thumb on the sternum or anterior tibia, which can elicit bone pain.7,40 One study showed that 93% of persons 10 to 65 years of age who were admitted to a hospital emergency department with muscle aches and bone pain and who had a wide ariety of diagnoses, including fibromyalgia, chronic fatigue syndrome, and depression, were deficient in itamin D.41

然而，骨质疏松症与骨痛无关联，而软骨病则与局部性或全身性骨痛有关。其原因被认为是骨膜下已去矿质化的胶原基质上发生的水合反应，水合的胶原基质在骨膜上向外扩张，引起阵痛。软骨病可通过以拇指适度挤压胸骨和胫骨前方以引起骨痛感。一项研究显示10岁到65岁中有93%的人向医院急诊室承认有肌肉疼痛和骨痛症状，他们还有一些其他症状包括纤维肌痛、慢性疲劳综合征、抑郁等，该研究显示他们都缺乏维生素D。本人已认领该文第9、10两部分，48小时后若未提交译文，请其他战友自由认领。本人已认领该文11、12部分编译，48小时后若未提交译文，请其他战友自由认领。本人认领第十三部分，48小时内交稿请战友纠错！

The model showed that if fifty percent of a high-risk community is vaccinated, many unvaccinated people also would be protected.

模型显示，如果50%的高危社会人口接种疫苗的话，很多未接种的人们将也被保护。

Sometimes I just feel like, quitting I still might Why do I put upthis fight, why do I still write Sometimes it's hard enough just dealin wit real life Sometimes I wanna jump on stage and just kill mics And show these people what my level of skills like But I'm still white, sometimes I just hate life Something ain't right, hit the brake lights Case of the stage fright, drawin a blank light Da-duh-duh-da-da, it ain't my fault Great big eyeballs, my insides crawl And I clam up, I just slam shut I just can't do it, my whole manhoods Just been stripped, I have just been vicked So i must then get, off this bus then split Man fuck this shit yo, I'm going the fuck home World on my shoulders as I run back to this 8 mile road I'm a man, I'ma make a new plan Time for me to just stand up, and travel new land Time for me to just take matters into my own hands Once I'm over these tracks man I'ma never look back (8 mile road) And I'm gone, I know right where I'm going Sorry mama I'm grown, I must travel alone Ain't gunna follow these footsteps, I'm making my own Only way I know how to escape from this 8 mile road I'm walking these train tracks, tryin to regain back the spirit I had fore I go back to the same crap To the same plant, in the same pants Tryin to chase rap, gotta move ASAP And get a new plan, mommas got a new mam Poor little baby sister, she don't understand Sits in front of the T.V, buries her nose in the pad And just colors until the crayon gets dull in her hand While she colors her big brother, her mother and dad Ain't no tellin what really goes on in her little head Wish I could be the daddy that neither one of us had But I keep runnin from something I never wanted so bad!

有时候，我不安，因为我不是尚未引爆这就像我长大的，但我是不会长大我两个坚果尚未不要有代表我的一步，没有获得足够的肽的压力很大的人，我只是设法做最新最好的和我尝试，单独坐在我哭泣哟我不会告诉任何谎言，而不是目前的推移我不祈求天空，请我开始你的上帝请不要让我bitchin holdin没有固定工作哟我希望你能听到我家无论身处何地哟我tellin您dawg我白琳这拖车明天告诉我的妈妈我爱她，亲吻婴儿的妹妹再见说你需要我whenevr婴儿我永远远但是，你我有爱摆脱的唯一途径，我知道和我回到你的第二个，我的打击我拥有的一切，我会成为我自己去工作，我去，回到这个八英里道我一个人，我作出了一项新的计划时间对我来说，只是站起来，新的土地和旅行时间对我来说，只是考虑到我的问题自己手中一旦我对这些歌曲的人我从来没有回头看（ 8英里路）和我走了，我知道在那里我会对不起妈妈我长大，我必须单独旅行不是贡纳按照下列脚步，我让我自己唯一的办法，我知道如何摆脱这个8英里道你得活到觉得，你没有你不会得到它或看到什么大问题是，为什么这不是skillest 这是walkin寄宿线底特律城市的界限这是不同的，这在一定意义，证书的真实性，您甚至从来没有见过但everthing对我来说，这是我的信誉你从来没有见过或听说闻见了一个真正的三菱商事谁是难以置信的相同pedastal为我可是我仍然未签名的，有一个粗略的时间坐在门廊智慧我的所有朋友和踢哑巴儿歌去工作和服务三菱商事的在lunchline 但是在关键时刻，我punchlines哪里去谁，我必须表明，我国流动到胸部如果要我去，我必须知道谁还是我刚才在另一个蟹斗因为我不是没有运气havin与这个小兔子，以便他妈的它也许我需要一个新的出路，我startin怀疑狗屎我有点怀疑feelin谁余空闲时我看起来像一个流浪汉，你我的衣服是不是狗屎在救世军设法挽救一个装备和它的冷设法前往这道另外我觉得对滞留在该battlin模式我的防守是如此，并有一件事我不想遗憾的是没有人，这个城市是没有乐趣没有太阳，真是太黑暗有时候，我只是觉得我被分开从每一个我的四肢，每一个我的一个朋友这足以使我只是想跳出我的皮肤有时我觉得自己像一个机器人，有时我只是不知道是我的乐队我的打击，我的头是一个炉灶顶部我只是爆炸，水壶会这么热有时候，我的嘴刚刚超载的屁股，我没有但是，我学到了，现在是时候让我掉头你只需要一个时间，我引火烧身不是不属于任何下一次我遇到一个新的女孩我可以不再扮演笨或未成熟我每一个组成部分，我需要的是勇气就像我已经有了节拍，所有我需要的话得到的冲动，突然它的进口激增突然爆发的一个新的能源已经发生时间显示这些自由世界领导人在三个第三我不再害怕现在，我作为一个自由鸟然后我又和越过中间遏制击中动词和所有你看到的是一个模糊的8英里道我一个人，我作出了一项新的计划时间对我来说，只是站起来，新的土地和旅行时间对我来说，只是考虑到我的问题自己手中一旦我对这些歌曲的人我从来没有回头看（ 8英里路）和我走了，我知道在那里我会对不起妈妈我长大，我必须单独旅行不是贡纳按照下列脚步，我让我自己唯一的办法，我知道如何摆脱这个八英里道

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。