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In this paper, with 2-oxo-propionic acid salicyloyl hydrazone as a ligand, one calcium complex, three copper complexes and thirteen rare earth(RE=La, Ce, Pr, Nd, Sm, Eu. Gd, Tb, Dy, Er, Tin, Yb and Lu) complexes have been synthesized. The crystals of four complexes were obtained, and the crystal structures were determined by single crystal X ray diffraction. One of the crystals is calcium complex, the other are binary and trinary complexes of copper.

本文选用2-羰基丙酸水杨酰腙作为配体,在水中分别与钙、铜、稀土(RE=La、Ce、Pr、Nd、Sm、Eu、Gd、Tb、Dy、Er、Tm、Yb和Lu)的盐反应,共制得了17种未见文献报道的配合物,另外还培养了2-羰基丙酸水杨酰腙、咪唑与铜、钙的二元及三元配合物的四种单晶,对La-Gd的稀土的配合物进行了溶解热的测定,并用Gauss-98软件包对铜的配合物进行了有关量化计算。

MethodsNonheparinized autohemic blood of the rat was taken out from rat"s femoral artery and injected into its caudate nucleus immediately to establish a model of intracerebral hemorrhage.The changes of edema in the ipsilateral bassal ganglia , ipsilateral cortex, contralateral bassal ganglia and contralateral cortex were measured at 1,2,3,5 and 7 days respectively after intracerebral hemorrhage. The rat"s packed red blood cells, lysed red blood cells and hemoglobins at different concentrations were injected respectively into the rat"s caudate nucleus. The changes of edema in various regions of the brain at different time were measured as above. 5U thrombin was injected into the rat"s caudate nucleus and the changes of edema in various regions of the brain at different time were measured as above.

自体股动脉取血,并采用自体未肝素化新鲜血回注法建立大鼠尾状核出血模型,观察脑出血后1,2,3,5,7天血肿同侧基底节区、血肿同侧对应的皮质区、血肿对侧对应的基底节区及血肿对侧对应的皮质区脑组织水分含量的变化;分别以自体浓缩红细胞(PRBC,50%)、溶解红细胞(LRBC,50%)、不同浓度的大鼠血红蛋白注入大鼠尾状核,并观察不同时间不同部位脑组织水分含量的变化;以5U凝血酶注入大鼠尾状核,观察不同时间不同部位的脑组织水分含量的变化。

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