有环的

The cytotoxicity of these compounds were valuated by MTT and SRB methods using three cancer cell lines: HL-60, A-549, P-388. Cyclo-shikonin, and cyclo-alkannin have high cytotoxicity against HL-60.The chiral center of side chain has no effect on their activity. 2- 1-(Acetyloxy-4-methyl-3-pentenyl -5, 8-dihydroxy-1, 4-naphthoquinone (105) has strong inhibition effect on P-388 cells. 2- 1-(isooctyloxy-4-methyl-3-pentenyl -5, 8-dihydroxy-1, 4-naphthoquinone (108) and 2- 1-(2-furoyloxy-4-methyl-3-pentenyl -5, 8-dihydroxy-1, 4-naphthoquinone (112) have high inhibition on A-549.Shikonin (1), alkannin (2), and their derivatives have the structural features of a planar chromophores and short side chain. We examined the ability to inhibit the telomerase.

抗肿瘤活性初步筛选测试采用小鼠白血病P-388肿瘤细胞和人肺癌A-549肿瘤细胞进行，结果表明侧链羟基的手性对抗肿瘤活性无明显影响；有数个化合物具有很好的体外抑制活性，特别是化合物2-（1-异辛酰氧基-4-甲基-3-戊烯基）-5，8-二羟基-1，4-萘醌（108）和2-[1-（2-呋喃甲酰氧基）-4-甲基-3-戊烯基]-5，8-二羟基-1，4-萘醌（112）体外显示对人肺癌A-549肿瘤细胞有强效；2-（1-乙酰氧基-4-甲基-3-戊烯基）-5，8-二羟基-1，4-萘醌（105）对小鼠白血病P-388肿瘤细胞有强效；环紫草素和环异紫草素对人白血病HL-60细胞有强烈抑制作用。

For the synthesis of NHC precursors, there are also several routes: condensation of glyoxal, amines and paraformaldehyde; alkylation of imidazole or monosubstituted imidazole with alkyl halide; annulation of ortho esters and 1,2-diamines; ring closure of hydrazines or amides with acetic anhydride; reduction of thiones with Na/K in THF.

关于N-杂环卡宾前体的合成途径主要有：乙二醛、伯胺和多聚甲醛的缩合反应；卤代烷与咪唑及其取代咪唑的烷基化反应；原甲酸酯与1，2-二胺的成环反应；肼或酰胺与酸酐的环化反应；用Na/K对环硫脲化合物的还原反应。

Results:The positive rate of HPV-DNA was 41.7%(20/48) and there were no significant difference on HPV infection in different groups of age,smegma and history of balanoposthitis.

结果：48例中，20例阳性，阳性率为41.7%；其中不同年龄段、有无包皮垢及有无感染史组间HPV阳性率均无显著性差异。结论：对需行包皮环切的男孩，应尽早施行包皮环切术。

Flow disciplinarian of different PH indicator polymer solution and newtonianliquid in annulus line had been studied, and found speed distributing, vortex,streamline of annulus line, analytic flow field distributing in annulus and eccentricsituation and compared the results with prevenient schloar, some results different fromprevenient results are get, shch as the relation of average velocity and maxiumvelocity is not less with the viscosity exponent under the annular line, the fluid speedaffect the relation.

应用 PIV 分别研究了不同浓度的聚合物溶液以及牛顿流体在垂直环空管道中的流动规律，得到了环空管道中流体的速度分布情况、涡量情况、流线情况，分析了同心和偏心情况下环空管道内的流场分布规律，并与前人的计算结果进行了比较，得出了一些与以前不同的结论：同心情况下平均流速与最大流速的关系，并不是完全与粘性指数 n 值有关系，还与管道内流动的流动速度有关系，当速度较小时，两者的差别就小，速度大时，不符合这种规律。

The changes of muscle protein content and pH values were observed. Results Thymus and spleen coefficients in high and low dosage group were 9.1±2.3, 6.3±1.1, respectively, and those of in the controll were 6.5±1.6, 3.4±0.5.The contents of muscle protein (g/100 g) in high, medium, and low dose groups were 24.68±0.55, 22.48±0.54, 21.22±1.25, respectively, lower than that of the control (31.83±2.36, P.05). Paramorphia of lymphocyte in high dose ciprofloxacin treated group was observed.

结果 对照组胸腺和脾脏系数分别为(9.1±2.3)，(6.3±1.1)mg/g，高剂量组胸腺和脾脏系数分别为(6.5±1.6)，(3.4±0.5)mg/g，与对照组比较，差异均有统计学意义（P.05或P.01）；而中、低剂量组的脾脏指数与对照组比较，差异均有统计学意义(P.05)；环丙沙星各剂量组与对照组比较，肌肉pH值变化不明显；环丙沙星高、中、低剂量肌肉蛋白质含量分别为(24.68±0.55)，(22.48±0.54)，(21.22±1.25)g/100 g，与对照组(31.83±2.36)g/100 g比较明显下降(P.05)；与对照组比较，高剂量组脾淋巴细胞形态异常。

The unstrapped, single-ring strapping and dual-strapping magnetron anode blocks are taken into consideration.

重点计算和比较了无隔模带、有一环隔模带和有两环隔模带结构磁控管的模式分隔度。

Current products are: Mat O ring seal suction cups water polo Washers Washers piece lamp set of silicone rubber ear pads nail dust cover jacket sealing rings ring.

现生产的产品有：脚垫 O环水球密封圈吸盘华司垫圈矽胶片灯头套胶钉垫片耳塞防尘套护套套环止水环等。

Results The main structure of the left ventricle in canine was composed of the mitral complex、aortic valve、falsetendons and so on,among them the mitral complex was included in the mitral ring and valve,chordae tendinease and papillary muscles;the circle of mitral ring was 49.16±10.00mm,the average heights of inside and outside valves were 14.28±3.14mm,9.27±1.99mm,respectively,the breadth were 25.74±5.21mm、21.50±6.33mm;the average number of chordae tendineass was 16.72±2.76;the average number of left ventricular false tendon was 4.69±3.38:the circle of aortic valve ring was 34.55±8.00mm,the average heights of left、right and back aortic valves were 6.85±1.76mm、7.19±1.75mm and 7.52±1.79mm.

结果：犬心左心室主要结构有二尖瓣复合体、主动脉瓣、假腱索等，其中二尖瓣复合体由瓣环、瓣膜、腱索、乳头肌构成；二尖瓣瓣环周径为49.16±10.00mm，内侧瓣、外侧瓣的高度分别为14.28±3.24mm、9.27±1.99mm，其宽度分别为25.74±5.21mm、21.50±6.33mm；腱索总数平均为16.72±2.76条；假腱索总数平均为4.69±3.38条；主动脉瓣瓣环周径为34.55±8.00mm，左瓣高度、右瓣高度和后瓣高度分别为6.85±1.76mm、7.19±1.75mm和7.52±1.79mm。

Changed the two screws on the contact plate of the Halo-Vest to one screw,so that the Halo-Vest can fit extension-flexion movement and adapt the reduction of cervical spinal dislocation.Simultaneously,in order not to reduce the fixed funtion of the contact plate,which was designed in fan-shape.

将传统的Halo-Vest架头环与架子接板的双螺丝改为单螺丝，使不能伸屈的头环变为能够伸屈；将头环与接板的咬合面设计成扇形并且有放射状条纹，使头环能牢固地固定在任何一个伸屈角度上。

Symptom : 1, dark blue iris surrounding tissue hypoxia representatives, two poor blood circulation and venous stasis Central lead to high blood viscosity, Blood, impaired pancreatic microcirculation, varicose veins, arthritis, etc. 3 sclerosis, a blue and white seepage: When discovered this phenomenon, Iridovirus can refer to the map of the reflection ring again to find the most appropriate for regional and Guasha-site physiotherapy.

症状：1、虹膜周围呈深蓝色代表组织缺氧，血液循环不好2、静脉淤血环会引起血粘度高、血脂高、微循环障胰、静脉曲张、关节硬化等等3、蓝色渗白色四周全都有易手肢冰冷，有贫血、低血压现象建议：当有发现此现象时，可参照虹彩各反射图的最外环再找出相应区域作松盘与刮痧的理疗。

Plunder melds and run with this jewel!

掠夺melds和运行与此宝石！

My dream is to be a crazy growing tree and extend at the edge between the city and the forest.

此刻，也许正是在通往天国的路上，我体验着这白色的晕旋。