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There was no significant difference in epithelial destruction, intra-luminal obstruction and BO formation between allografts from HO-1 transgenic pigs or non-transgenic pigs. However, in day 28 and 56 allografts, we did see some of the grafts still showed bronchiole structure with normal epithelial cells which hasn'tbeen found before.

使用HO-1 基因猪的异体移植肺块,在气管表皮破坏、气管内径阻塞、及阻塞性细支气管炎形成的程度,与使用非基因猪并无显著差异,惟在第28 天及56 天的肺块中,有部份的异体移植肺块中可见正常的支气管型态及表皮细胞。

RESULT: In vitro, TISE at the concentrations of 760 and 380 mgL-1 had significant antagonistic effect on the normal bronchus slice contraction caused by histamine as well as on the sensitized bronchus slice contraction caused by egg albumin, but had no effect on the contraction caused by acetylcholine. in vivo, TISE at doses of 25 and 18 mgkg-1 could significantly prolong the latent period of expiratory dyspnea, tic and falling down caused by egg albumin in sensitized guinea pigs.

结果:离体实验,TISE 760,380 mgL-1对组胺致正常豚鼠气管片的收缩具有对抗作用,对卵白蛋白所致的致敏豚鼠支气管平滑肌收缩有极显著的抑制作用(P<0.01),而对乙酰胆碱所致气管片收缩无明显影响;整体实验,TISE 25,18 mgkg-1可显著延长卵白蛋白所致的致敏豚鼠呼吸困难、抽搐和跌倒的潜伏期(P<0.01)。

PART FOUR EFFECTS OF MIL-4RA EXPRESSION VECTOR ON ASTHMATIC AIRWAY INFLAMMATION AND TH1/TH2 CELL DISFUNCTION THROUGH INTRAPERITONEAL ADMINISTRATION In the study of part three, we treated the mouse asthmatic model by intratracheal administration with mIL-4RA expression plasmid and observed obvious therapeutic effects. But intratracheal administration belongs to one of the insult therapies.

第四部分:腹腔注射mIL-4RA重组载体对哮喘小鼠气道炎症及Th失衡的干预作用前一部分研究中我们通过气道局部干预途径,即气管内直接滴注的方式,观察到mIL-4RA真核表达质粒对哮喘小鼠具有很好的治疗作用,但气管内滴注毕竟属有创性治疗,存在需要实验条件高,有较大的风险性,不易反复进行等缺点,这势必大大限制其在动物实验及进一步临床研究中的实际应用价值。

Tracheal injury is a potentially lethal event in patients with difficult laryngoscopy and the use of ELM.

在难气管插管的病人合并使用外在laryngeal 操作时是有可能发生气管受伤的。

After surgery,all patients had SpO2 somewhat declined.6 had lung infection.6 were removed of bronchial secretion by bronchoscope.2 were supported by ventilator by using intubation.2 underwent tracheotomy.1 had disturbances of acidbase balance and treated by using hydrochloric acid muriatic acid.

术后所有病人PaO2均有不同程度的下降,6例出现肺部感染,6例行纤维支气管镜吸痰,2例通过气管插管给予呼吸机支持,2例行气管切开术,1例酸碱平衡紊乱使用盐酸精氨酸治疗。

objective to discuss perioperative complication and management of patient with high risk copd following esophagectomy.methods 45 patients with high risk copd underwent esophagectomy with epidural block combined with general anesthesia.perioperative treatment included smoking cessation,chest physiotherapy,prevention and control of infection of air way and appropriate bronchodilators of air way,breathing exercises,nutrition support and oxygen therapy.painkiller was instilled after surgery,early exercises,ensuring unobstruction of the air way,mechanical ventilation was applied when needed.results 3 had hypoxaemia in operation.after surgery,all patients had spo2 somewhat declined.6 had lung infection.6 were removed of bronchial secretion by bronchoscope.2 were supported by ventilator by using intubation.2 underwent tracheotomy.1 had disturbances of acid base balance and treated by using hydrochloric acid muriatic acid.all patients recovered rather smoothly and discharged from hospital.conclusion high risk copd is not the absolute contraindication of esophagectomy.active management before and after surgery ensures the safety and recovery of patients.

目的 探讨重度慢性阻塞性肺疾病简称慢阻肺病人食管切除术围手术期常见并发症及其处理。方法 45例重度慢阻肺的病人在全麻联合硬膜外阻滞下进行开胸食管切除手术,围手术期处理包括术前戒烟、胸部理疗、预防和控制呼吸道感染、解痉化痰、呼吸功能锻炼、营养支持和氧疗;术后硬膜外镇痛、早期锻炼、保持呼吸道通畅,部分病人予以呼吸支持。结果术中3例出现低氧血症。术后所有病人pao2均有不同程度的下降,6例出现肺部感染,6例行纤维支气管镜吸痰,2例通过气管插管给予呼吸机支持,2例行气管切开术,1例酸碱平衡紊乱使用盐酸精氨酸治疗。所有病人均痊愈出院。结论重度慢阻肺病人并非开胸食管切除手术的绝对禁忌证,积极的术前准备和严格的术后管理可减少和控制术后急性发作,有助于确保此类病人的围手术期安全和康复。

Design, Setting, and Patients After exposure to an index patient whose fatal illness was characterized by fever and hemorrhage at a primary care hospital and regional tertiary care hospital's isolation ward, secondary cases with febrile illness who were suspected of being exposed were tested for antibodies against Anaplasma phagocytophilum and by polymerase chain reaction and DNA sequencing for A phagocytophilum DNA.

2006年11月9日与17日之间在中国安徽省的一家地区医院中,为数9人的具有发烧和其它症状的病人被诊断患有HGA。这些病人都没有被蜱叮咬过。但所有这9位病人都在指标病例死亡前12小时内与其有过接触,该指标病例被怀疑患有致命性HGA,她出现了大出血并接受了气管内插管(即将一根柔韧的塑胶管子置放在气管中以帮助肺部的通气。)。

SIgA cell distributed in interstitice Harderian Gland, mainly in epithelium and around gland epithelium of the duct and acini, especially mature plasma cell clung to gland epithelium.

气管中SIgA细胞主要分布在气管黏膜上皮之间和固有膜处,局部黏膜上皮形成小隐窝,隐窝内和隐窝下的固有膜中有较多的SIgA型浆细胞。

It was possible to achieve centric occlusion in 79 of 80 children with the endotracheal tube positioned in the retromolar space. Retromolar intubation was successfully accomplished in six pediatric patients undergoing maxillomandibular fixation and maxillofacial surgery.

在80个臼齿后放置气管导管的患儿中间有79例可达到牙齿中央闭合。6例行颌间固定术和腭面外科手术的患儿成地进行了臼齿后气管插管。

Although there has been great progress in tracheal stents, ideal stents need further development and exploration.

现行的气管支架已经有了很大的进步与发展,但理想的气管支架还有待进一步的深入开发与研究。

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