有毒性的

Conclutions Topotecan is an effective remedy for treatment of small cell lung cancer, both single topotecan and combined regimen has the same effect as the traditional first-line regimen, though myelo-suppression such as leucopenia and thrombopenia is more sever, the adverse effect is tolerated. Though it has been recommended as second-line agent for chemo-therapy sensitive small cell lung cancer, there needs more clinical studies to verify its role in first-line.

结论拓扑替康是在小细胞肺癌的治疗中有确切临床疗效的药物，无论是单药还是与其他药物的联合用药均具有与当前一线经典方案相当的疗效，虽具有相对高的致白细胞和血小板下降的骨髓毒性，但毒副作用可耐受，已经被认为是治疗对化疗敏感的小细胞肺癌患者的二线推荐药物，但是作为一线用药仍然需要更多的临床证据来证实。

UCK is able to catalyze phosphorylation of its physiological substrate uridine and cytidine, and it also plays important roles for the phosphorylation of nucleoside analogs that are being investigated for possible use in chemotherapy of cancer, such as 6-azauridine, 5-fluorouridine and so on.

将表达UCK不同丰度的肝癌细胞进行6-氮尿苷的敏感试验显示，6-氮尿苷对UCK表达量较高的HepG2细胞的毒性作用强于对UCK表达量较低的L02细胞，提示UCK有可能成为临床用药的一个参考指标，克隆人类尿苷胞苷激酶对寻找新的嘧啶核苷类似物并研究它们的药理活性有着重要的意义。

Objective To investigate whether tyrosine protein kinases Src and Fyn were involved in the phosphorylation of NR2A induced by cerebral ischemia followed by reperfusion. Methods Transient (15 min) brain ischemia was induced by the four-vessel occlusion in Sprague-Dawley rats. The antisense oligodeoxynucleotides of Src and Fyn were used to suppress the expression of Src and Fyn by intracerebroventricular infusion once a day for 3 days before ischemia.

近年来，最受人们关注的缺血性脑损伤机制是兴奋性氨基酸（excitatory amino acid， EAA）的神经毒性作用及神经元内钙超载触发的级联反应［1］，其中NMDA受体的NR2亚基在缺血性脑损伤中起着非常重要的作用，在缺血/再灌注（ischemia/ reperfusion，I/R）过程中其蛋白表达、磷酸化水平均有改变。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。